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Best Polyphenol Supplements

Polyphenols are micronutrients and phytochemicals that have antioxidant and anti-inflammatory properties. Polyphenol-based supplements are most commonly sourced from berries, herbs, and various spices and most contain a variety of broad-spectrum polyphenols that provide full-body support.

In this article, we’ll discuss what polyphenols are in further detail and review their major health benefits. Additionally, we’ll cover the best polyphenol supplements available.

What Are They and What Do Polyphenols Do?

  • Polyphenols are compounds found naturally in foods that have antioxidant properties
  • The most common forms of polyphenols are flavonoids and phenolic acids
  • The top 3 foods with the highest concentration of polyphenols include cloves, dried peppermint, and star anise
  • Polyphenols defend the body from free radical damage, boost the immune system, aid digestion, and improve energy

Comparison of the 4 Best Polyphenol Supplements

Best on Amazon
Green Tea Extract
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Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best on Amazon
Green Tea Extract

This product contains 500 milligrams of green tea leaf extract per serving which is standardized to contain 50% polyphenols, 35% catechins, and 15% EGCG.

Powder Form
500 mg Daily
Vegan Friendly
Pure Green Tea Extract
$0.06/Serving

Best Polyphenol Supplement
Resveratrol Rapid + by Nuzena
2
Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best Polyphenol Supplement
Resveratrol Rapid + by Nuzena

This capsule form of resveratrol provides natural antioxidant and anti-inflammatory support for helping to lower blood pressure, support healthy blood sugar levels, and promote longevity.

Capsule Form
2 Capsules Daily
Veggie Capsules
50% Trans-Resveratrol
$1.17/Serving

Best Elderberry Supplement
Elderberry Gummies
3
Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best Elderberry Supplement
Elderberry Gummies

This 4-in-1 formula contains the major immune-boosting ingredients of Sambucus nigra (Black Elderberries), Vitamin C, Echinacea purpurea, and Propolis.

Gummy Form
Vegetarian Friendly
2 Gummies Daily
Contains Black Elderberries
$0.57/Serving

Best Custom Polyphenol Supplement
Persona Nutrition
4
Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best Custom Polyphenol Supplement
Persona Nutrition

Persona offers personalized daily vitamin packs with numerous add-in options that contain polyphenols.

Capsule Form
1 Vitamin Pack Daily
Vegan Friendly Options
Grape Seed Extract
Individual Ingredients $0.12-$1.57 Daily

Best Polyphenol Supplements

Best Polyphenol Blend – Resveratrol Rapid + by Nuzena

Best Polyphenol Supplements

Resveratrol Rapid + was specifically designed by health professionals to provide customers with natural antioxidant and anti-inflammatory support.

Not only does this product provide an immune system boost, but it also helps lower blood pressure and aid the management of blood sugar levels.

Studies have displayed resveratrol’s effectiveness in increasing the lifespan of certain organisms as well as increasing nitric oxide which leads to a blood-pressure-lowering effect.

It is recommended for adults to take 2 capsules daily of this product. Each daily serving of Resveratrol Rapid + contains 2400 mg of 50% trans-resveratrol complex.

Pros
  • Free health specialist assistance

  • Clinically proven results

  • Veggie capsules

Cons
  • 2 capsules daily

  • Only contains 50% of the active ingredient

custom multivitamin pack

Best Elderberry Supplement – Elderberry Gummies by Essential Elements 

Best Multivitamins for Kids

This 4-in-1 formula contains the major immune-boosting ingredients of Sambucus nigra (Black Elderberries), Vitamin C, Echinacea purpurea, and Propolis.

Elderberries are one of the top 10 natural sources of antioxidants and contain the following major flavonoids: anthocyanins C3G, cyanidin-3-o-sambubioside (C3S), hyperoside, isoquercetin, quercetin

A systematic review of multiple human trials has shown that elderberries might reduce symptoms of respiratory infections. [27] Additionally, a randomized controlled trial with 312 participants also suggested that the extract of the elderberry fruit reduced the severity and duration of a cold significantly more than placebo. [28]

It is recommended to take 2 gummies per day.

Pros
  • Elderberries are one of the top 10 foods containing the highest concentration of polyphenols

  • Comes in the form of chewable gummies

  • Contains 4 immune-boosting ingredients

Cons
  • Contains 4 grams of sugar per serving

  • Made with corn syrup

Best Custom Polyphenol Supplement – Persona 

Best Prenatal Vitamins

Persona Nutrition provides each of its customers with their own personalized, monthly subscription vitamin pack to best meet their specific health needs.

In order to best customize individual vitamin packs, customers should initially complete a quick assessment on Persona’s website to receive personalized, science-backed supplement recommendations.

Specific questions on this assessment gather information on specific types of diets, allergies and food sensitives, health conditions, medication use, and more.

Alternatively, customers may also use the option to filter vitamins by certain health needs on the products page. Ingredients offered by Persona that contain polyphenols include:

  • Astragalus
  • Bilberry
  • Cranberry
  • Fermented Ginseng
  • Feverfew
  • Ginger Extract
  • Ginkgo Biloba Extract
  • Green Tea Extract
  • Olive Leaf
  • Peppermint Plus
  • Pycnogenol®
  • Quercetin Plus
  • Turmeric
  • Vitamin C with Bioflavonoids

All vitamins and supplements offered by Persona adhere to FDA certified Good Manufacturing Practices and several of the ingredients included within its vitamin packs are trademarked, providing customers with greater transparency and trust.

Pros
  • Quick online questionnaire

  • Free nutritionist consultations via app

  • Fastest turnaround time

  • 40% off TWO months

  • Companion app with reminders, assessments, and support

Cons
  • If you’re not careful you can end up with too many pills for each day (yuck!)

Muscle + Brawn Readers Get An Exclusive 40% off Two Months By Using Our Link Below

Best Green Tea Extract
– Green Tea Extract by Bulk Supplements 

Best Polyphenol Supplements

Green Tea Extract by BulkSupplements is one of the most powerful antioxidant supplements offered by the company and is known for providing a wide range of health benefits. Some of the major benefits of taking green tea extract include a reduction in inflammation, a natural increase in energy, accelerated fat loss, improved cognition, and healthier skin.

This product contains 500 milligrams of green tea leaf extract per serving which is standardized to contain 50% polyphenols, 35% catechins, and 15% EGCG. Additionally, Green Tea Extract is free of sugar, soy, dairy, yeast, gluten, and corn and contains no other ingredients.

This product comes in pure powder form and is sold in quantities ranging from 100 grams to 25 kilograms. Adults should take 500 milligrams once or twice daily or as directed by a physician.

BulkSupplements offers over 500 supplements which fall under categories such as fitness and sports, heart health, brain and memory, weight management, and immune support. All of its products contain pure raw ingredients, are lab tested for purity, and are manufactured at a facility that is FDA inspected. BulkSupplements stands out among its competitors due to its product versatility and ability to serve customers who stem from diverse health backgrounds, lifestyle choices, and dietary preferences.

Pros
  • Natural source of caffeine

  • Contains polyphenols

  • Contains no other ingredients or additives

Cons
  • Only sold on direct website

  • Doesn’t list exact amount of EGCG

  • Polyphenol percentage could be much higher

Types of Polyphenols

There are over 8,000 different polyphenols found in food. Nearly 60% of polyphenols are classified as flavonoids and around 30% are classified as phenolic acids

Flavonoids can be further split into flavonols, flavones, flavanones, flavanols, anthocyanins, and isoflavones. This type of polyphenol can be found in foods such as onions, tea, wine, citrus fruits, aromatic herbs, chocolate, and some soybean-derived products.

Phenolic acids can be split into 2 subclasses of benzoic acid and cinnamic acid. This type of polyphenol is generally found in foods including fruits, vegetables, seeds, and whole grains.

Polyphenol Rich Foods

The European Journal of Clinical Nutrition (EJCN) conducted a study to find which foods and food groups contained the highest concentration of polyphenols. Over 452 foods were analyzed from the Phenol-Explorer database and it was found that the following 10 food sources contained the highest overall concentration of polyphenols:

  1. Cloves
  2. Peppermint, dried
  3. Star anise
  4. Cocoa powder
  5. Mexican oregano, dried
  6. Celery seed
  7. Black chokeberry
  8. Dark chocolate
  9. Flaxseed meal
  10. Black elderberry

Additionally, the data analysis showed that the 5 food groups containing the most food items with the highest polyphenol content were seasonings, fruits, seeds, vegetables, and non-alcoholic beverages.

custom multivitamin pack

Polyphenols Supplements

Polyphenol supplements usually provide either a variety of broad-spectrum polyphenols sourced from superfoods, berries and herbs or contain high-purity, high-potency extracts. The best polyphenol supplements include ingredients sourced from resveratrol-containing foods, elderberries, bilberries, cranberries, green tea extract, quercetin, turmeric, bitter orange, and chokeberries.

When selecting a polyphenols supplement you should make sure to choose a product that has anti-inflammatory properties and combats free radical damage through the use of potent antioxidants.

Polyphenols Benefits

The main health benefits of polyphenols include shielding the body from the toxic effects of free radicals, enhancing homeostasis, and preventing disease.

Some sources of polyphenols may also serve as prebiotics which boost the ratio of useful bacteria in the gut. This in turn aids blood sugar and weight management as well as reduces the risk of forming certain chronic diseases.

Polyphenols for Skin

The plant polyphenols possess anti-inflammatory, immunomodulatory, anti-oxidant properties and DNA repair activities, and that can be exploited for the prevention of variety of skin disorders caused by excessive exposure to solar UV lightPolyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis

Polyphenols for Weight Loss

Recently, natural bioactive phytochemicals present in foods have been discovered for their potential health benefit effects on the prevention of chronic disorders such as cancer, cardiovascular disease, inflammatory and metabolic diseases including obesity.Dietary Polyphenols and Obesity

What’s the Verdict on Polyphenols?

All of the above supplements provide immune-boosting and anti-aging benefits. Although some of the components of these supplements can be obtained from superfoods, the overall availability of these components within supplements is much higher and provides a wider realm of health benefits.

Best on Amazon
Green Tea Extract
1
Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best on Amazon
Green Tea Extract

This product contains 500 milligrams of green tea leaf extract per serving which is standardized to contain 50% polyphenols, 35% catechins, and 15% EGCG.

Powder Form
500 mg Daily
Vegan Friendly
Pure Green Tea Extract
$0.06/Serving

Best Polyphenol Supplement
Resveratrol Rapid + by Nuzena
2
Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best Polyphenol Supplement
Resveratrol Rapid + by Nuzena

This capsule form of resveratrol provides natural antioxidant and anti-inflammatory support for helping to lower blood pressure, support healthy blood sugar levels, and promote longevity.

Capsule Form
2 Capsules Daily
Veggie Capsules
50% Trans-Resveratrol
$1.17/Serving

Best Elderberry Supplement
Elderberry Gummies
3
Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best Elderberry Supplement
Elderberry Gummies

This 4-in-1 formula contains the major immune-boosting ingredients of Sambucus nigra (Black Elderberries), Vitamin C, Echinacea purpurea, and Propolis.

Gummy Form
Vegetarian Friendly
2 Gummies Daily
Contains Black Elderberries
$0.57/Serving

Best Custom Polyphenol Supplement
Persona Nutrition
4
Best Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol SupplementsBest Polyphenol Supplements
Best Custom Polyphenol Supplement
Persona Nutrition

Persona offers personalized daily vitamin packs with numerous add-in options that contain polyphenols.

Capsule Form
1 Vitamin Pack Daily
Vegan Friendly Options
Grape Seed Extract
Individual Ingredients $0.12-$1.57 Daily

References

See all references
  1. Cheng, Y. C., Sheen, J. M., Hu, W. L., & Hung, Y. C. (2017). Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke. Oxidative medicine and cellular longevity, 2017, 8526438. https://doi.org/10.1155/2017/8526438
  2. Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018). The Role of Polyphenols in Human Health and Food Systems: A Mini-Review. Frontiers in nutrition, 5, 87. https://doi.org/10.3389/fnut.2018.00087
  3. Francis ST, Head K, Morris PG, Macdonald IA. The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol. 2006;47 Suppl 2:S215-20. doi: 10.1097/00005344-200606001-00018. PMID: 16794461.
  4. Grosso, G., Stepaniak, U., Micek, A., Kozela, M., Stefler, D., Bobak, M., & Pajak, A. (2017). Dietary polyphenol intake and risk of type 2 diabetes in the Polish arm of the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study. The British journal of nutrition, 118(1), 60–68. https://doi.org/10.1017/S0007114517001805
  5. Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C., & Rahu, N. (2016). Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?. Oxidative medicine and cellular longevity, 2016, 7432797. https://doi.org/10.1155/2016/7432797
  6. Khoo, H. E., Azlan, A., Tang, S. T., & Lim, S. M. (2017). Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food & nutrition research, 61(1), 1361779. https://doi.org/10.1080/16546628.2017.1361779
  7. Kim, Y., Keogh, J. B., & Clifton, P. M. (2016). Polyphenols and Glycemic Control. Nutrients, 8(1), 17. https://doi.org/10.3390/nu8010017
  8. Krishna Kumar, Abin Issac, Eapen Ninan, Ramadassan Kuttan, Balu Maliakel, Enhanced anti-diabetic activity of polyphenol-rich de-coumarinated extracts of Cinnamomum cassia, Journal of Functional Foods, Volume 10, 2014, Pages 54-64, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2014.05.008.
  9. Liao JC, Deng JS, Chiu CS, Hou WC, Huang SS, Shie PH, Huang GJ. Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo. Evid Based Complement Alternat Med. 2012;2012:429320. doi: 10.1155/2012/429320. Epub 2012 Mar 27. PMID: 22536283; PMCID: PMC3318905.
  10. Manach C., Williamson G., Morand C., Scalbert A., Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. The American Journal of Clinical Nutrition. 2005;81(1, supplement):230S–242S.
  11. Mennen LI, Walker R, Bennetau-Pelissero C, Scalbert A. Risks and safety of polyphenol consumption. Am J Clin Nutr. 2005 Jan;81(1 Suppl):326S-329S. doi: 10.1093/ajcn/81.1.326S. PMID: 15640498.
  12. Pallauf K, Rimbach G, Rupp PM, Chin D, Wolf IM. Resveratrol and Lifespan in Model Organisms. Curr Med Chem. 2016;23(41):4639-4680. doi: 10.2174/0929867323666161024151233. PMID: 27781945.
  13. Pérez-Jiménez J, Neveu V, Vos F, Scalbert A. Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. Eur J Clin Nutr. 2010 Nov;64 Suppl 3:S112-20. doi: 10.1038/ejcn.2010.221. PMID: 21045839.
  14. Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International journal of biomedical science : IJBS, 4(2), 89–96.
  15. Scalbert A, Manach C, Morand C, Remesy C, Jimenez L (2005). Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45, 287–306.
  16. Sorond FA, Lipsitz LA, Hollenberg NK, Fisher ND. Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat. 2008 Apr;4(2):433-40. PMID: 18728792; PMCID: PMC2518374.
  17. Tsao R. (2010). Chemistry and biochemistry of dietary polyphenols. Nutrients, 2(12), 1231–1246. https://doi.org/10.3390/nu2121231
  18. Venturini, C. D., Merlo, S., Souto, A. A., Fernandes, M., Gomez, R., & Rhoden, C. R. (2010). Resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes. Oxidative medicine and cellular longevity, 3(6), 434–441. https://doi.org/10.4161/oxim.3.6.14741
  19. Wang, J., Tang, L., & Wang, J. S. (2015). Biomarkers of Dietary Polyphenols in Cancer Studies: Current Evidence and Beyond. Oxidative medicine and cellular longevity, 2015, 732302. https://doi.org/10.1155/2015/732302
  20. Williamson G. (2017). The role of polyphenols in modern nutrition. Nutrition bulletin, 42(3), 226–235. https://doi.org/10.1111/nbu.12278
  21. Xia N, Förstermann U, Li H. Resveratrol and endothelial nitric oxide. Molecules. 2014 Oct 9;19(10):16102-21. doi: 10.3390/molecules191016102. PMID: 25302702; PMCID: PMC6270738.

 

Kathryn Giuffrida MPH

Kathryn Giuffrida MPH

Kathryn obtained a MPH in Toxicology & Risk Assessment from the University of South Florida in 2018. She's also a year-round swimmer who qualified to compete in the 2020 TYR Pro Series.

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