As more people are desiring to live forever, the dynamics of clinical trials and scientific research has shifted toward cracking the code that could allow people to delay the onset of aging.
While various synthetic peptides and compounds have been developed that could potentially help you live longer, there is always a risk of side effects when artificially synthesized supplements are intaken.
Delaying the aging process with the help of anti-aging supplements doesn’t just imply prolonging your life span but those anti-aging supplements should also provide other health benefits, such as mitigating the risk of developing any chronic diseases as well as improving overall energy metabolism.
While all of this may not be possible while taking artificially synthesized anti-aging supplements, naturally present molecules and compounds present inside the body may help you for sure.
One such naturally present molecule that we are talking about today is Nicotinamide mononucleotide, also more popularly known as NMN.
Scientists claim that this molecule could bring a breakthrough in anti-aging research. Let’s dig into every detail related to the NMN.
This article will help you decide whether NMN supplements should be your companion and also I will also list down the top and trusted vendors selling NMN supplements.
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What Is The Best NMN Supplement?
What is NMN?
NMN, also known as Nicotinamide mononucleotide, is a nucleotide comprising ribose, nicotinamide, and a phosphate group attached to it (1). This bioactive nucleotide has a Pyridine base attached to it. Because of its chemical structure, it is acidic in nature as well as water-soluble.
If by any chance, you haven’t heard about NMN, you must have heard about Nicotineamide dinucleotide or NAD+. NAD+ is an important co-factor required for many biological reactions occurring inside the body.
NMN is a precursor to NAD+ and is a very critical molecule required for increasing NAD+ levels in the cells (2). Without NAD+, it can be easily said that one couldn’t be able to survive. NMN is found in the nucleus, cytoplasm, and mitochondria of the cells.
NMN is itself a derivative of Vitamin B3, more commonly known as Niacin.
While NMN can be obtained from eating various fruits and vegetables, such as cabbage, broccoli, tomatoes, etc, sometimes augmenting natural food sources with NMN supplements can dramatically prove beneficial.
How Does NMN Work?
Because NMN is mostly concerned with delaying the aging process via increasing the levels of NAD+, let’s try to understand the biochemical pathway.
NMN derived from Niacin or vitamin B3 can cross the cell membranes, and enter the cells with the help of an enzyme called Slc12a8.
After entering the cytoplasm of the cells, NMN can be readily converted to NAD+. Once NAD levels rise in the cells, many biochemical pathways are initiated, such as DNA repair, increasing muscle mass, improving vascular health as well as strengthening the immune system. All of this eventually contributes to slowing the aging process and prolonging your lifespan.
Benefits of NMN
Perhaps one of the obvious and primary benefits of the NMN supplement is the enhancement of mitochondrial function (3). Because NMN serves as a direct precursor to NAD+, higher levels of NMN mean our mitochondria is provided with more NAD+ to be used in cellular respiration, thus more energy is made available for the bodily functions to be performed. This also ensures that our cellular health is maintained.
Not only this but the impaired mitochondrial function is also linked to cardiovascular disorders, such as Heart Failure, etc (4). This is because cardiac muscle doesn’t take rest for a second unlike skeletal and smooth muscle found in the body. Thus, in order to meet the heavy energy requirements of the heart, the availability of NMN and NAD+ is absolutely necessary.
Because higher levels of NMN mean increased NAD levels, which in turn implies an increased supply of energy, thus you can expect an increased lean muscle mass and improved muscle health.
Increased levels of NMN is also linked to a lowered risk of obesity. This is largely due to the fact that NMN stimulates metabolism, which means it facilitates the conversion of food into energy. Besides, evidence suggests that NMN can improve the lipid profiles in individuals and manage insulin sensitivity in individuals. All of these means there is a much lesser chance of developing metabolic syndrome, etc (5,6).
One of the research involving mice also showed that NMN may also increase blood flow to the brain (7). This means that there is a constant supply of oxygen and nutrients to our brain, therefore improving memory and cognition.
Although there is limited evidence, research suggests that NMN supplementation also has the potential to make our blood vessels rather more effective and improve the delivery system.
Every time our cell divides, there is a loss in DNA. The loss in DNA means valuable genetic information is lost during the process of cell division. Loss in DNA information alongside damaged DNA is associated with the aging process.
Research suggests that NMN supplementation can elongate the telomeres by activating a group of proteins called sirtuins, thus causing DNA repair and facilitating the slow aging process (8,9).
NMN health benefits seem to be widespread whether it is mitigating the risk of developing cardiovascular diseases, reducing the likelihood of getting diagnosed with metabolic syndrome, enhancing metabolism, or triggering DNA repair. All these potential benefits are directly or indirectly linked to prolonging your life and health span and offer you anti-aging benefits!
Side Effects of NMN
While the side effects of NMN may not be much of a headache to consider, overdosing with NMN may trigger adverse effects, such as stomach discomfort, indigestion, diarrhea, etc.
Nonetheless, human trials show no evidence of any side effects caused by NMN if taken within optimal dosage limits.
And, I believe that because NMN is found naturally in the body and works to boost metabolism all on its own, side effects shouldn’t really be a thing to worry about!
Is NMN Legal?
Because NMN comes under the category of “nutritional supplement”, it is allowed in the USA to legally buy and consume NMN supplements.
Just for your information, NMN is not an FDA-approved drug.
On the other hand, in countries like Europe and China, it is illegal to consume NMN supplements.
Who Should Use NMN?
Because of its potential role in minimizing age-related decline, anyone aspiring to live longer and healthier can choose NMN supplements.
NMN is also known to optimize your cardiovascular health and optimize your mitochondrial functioning. Thus, anyone who wants to be on the safe side in terms of heart health can buy NMN supplements.
Perhaps NMN also improves your energy metabolism in the most natural ways, so if that is your goal, buy NMN supplements straight away.
Because NMN supplementation offers a wide array of benefits, the precise dosage requirements may seem to vary with the purpose of intake.
Nonetheless, clinical trials show that NMN dose up to as high as 500mg seems to be safe with no report of adverse effects experienced by the users.
Maybe what you can do is start with 100mg of NMN (low NMN dose) and then gradually make your way up. This would give you an idea of what precise dose works well for you!
Forms of NMN
With so much research going on involving NMN, scientists are trying out different forms of NMN supplements to see which one works best for the users with all the confounding factors considered such as bioavailability, efficacy, etc.
Perhaps you will find NMN tablets, NMN capsules, NMN powder, NMN gel, and liposomal NMN in the market. With all the possible options on your table, you can choose whichever works optimally for you.
Which form of NMN is best?
Again, as more people are turning to different supplements, research surrounding the best way to deliver NMN is also making developments.
One of the problems that people usually face when trying out different supplements is the bioavailability of the supplement. This is because when the oral form of NMN is used, there is always a risk of breakdown of the active ingredients along the pathway to the GI tract. This results in a loss of potency and efficacy of the supplement.
This is where liposomal NMN comes into play!
Liposomal NMN ensures that the active ingredients are kept intact in a capsule made up of phospholipids. Because phospholipids can easily cross the cell membranes, this ensures that liposomal NMN active ingredients reach the target sites and there is an overall good biodistribution and absorption to achieve optimal benefits.
What is the best time to take NMN supplement?
While this question needs more research, it generally seems that the ideal time to take NMN is in the morning because that will ensure that your energy levels are elevated throughout the day to make you feel productive and energized.
What brand of NMN does David Sinclair use?
While he doesn’t endorse any NMN brand, reports suggest that he did use GMP NMN.
Which is better NMN or NR?
Although the obvious difference between NMN and NR is size, it is worth noting that NMN is further down the metabolic pathway as compared to NR. Moreover, research also suggests that NMN possesses greater efficiency and efficacy.
Should I take NAD or NMN?
Because NMN is a precursor to NAD, you can choose either of them but I would recommend using NMN because as you age, your NAD levels decline. Thus, NMN supplements would ensure an elevated level of NAD.
Does NMN need to be refrigerated?
If you are mixing into a liquid solution, the answer is Yes, then. This will ensure the full potency of the NMN supplement for a longer duration.
At what age should you start taking NMN?
If you are in your 30s, you can use the NMN supplement without any worries.
How long does it take for NMN to start working?
NMN works pretty fast as it gets absorbed within 2 to 3 minutes into your bloodstream.
Does NMN regrow hair?
There is not much research on this. If you consider the anti-aging effects of NMN, you may think yes but the answer is quite in the gray area.