Best Anti-Aging Supplements

Anti-aging supplements contain antioxidants and other natural ingredients that can reduce oxidative stress and improve the body’s overall function. Scientific research suggests that some of these compounds may significantly reduce the signs of aging through improving the function of different organs and tissues.

In this article, we’ll review the 3 best anti-aging supplements and also highlight the major health benefits and potential side effects of their key ingredients.

3 Best Anti-Aging Supplements

Best for Metabolic Health
Resveratrol Rapid + by Nuzena
1
Best Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging Supplements
Best for Metabolic Health
Resveratrol Rapid + by Nuzena

This capsule form of resveratrol provides natural antioxidant and anti-inflammatory support for helping to lower blood pressure, support healthy blood sugar levels, and promote longevity.

Capsule Form
2 Capsules Daily
Veggie Capsules
50% Trans-Resveratrol
$1.17/Serving
Best for Energy and Longevity
Energy by Performance Lab
2
Best Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging Supplements
Best for Energy and Longevity
Energy by Performance Lab

Energy provides superior mitochondrial support for cell energy and vitality through the use of MicroActive® Q10, BioPerine®, BioPQQ® and Bio-Enhanced® nutrition technology.

Capsule Form
2 Capsules Daily
Vegan Friendly
5 Potent Supplements
$1.63/Serving
3
Best Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging Supplements
Best for Wrinkles
Collagen Peptides by Essential Elements

This product contains hydrolyzed, type I & III Collagen peptides that are sourced from grass-fed, pasture-raised, Grade A bovine.

Powder Form
1 Scoop per Serving
Keto Friendly
Grass-Fed Bovine
$0.73/Serving
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TL; DR: What to Know About Anti-Aging Supplements

  • Most anti-aging supplements contain antioxidants that prevent cellular damage.
  • Resveratrol and pterostilbene aid metabolic health.
  • Flavonoids, such as fisetin, may remove damaged cells and preserve brain health.
  • Turmeric has powerful anti-inflammatory properties and promotes joint health.
  • Coenzyme Q10 may protect the heart in older adults.
  • Vitamin B3 may help the liver combat the effects of aging.
  • Vitamin C and collagen may reduce the effects of aging on the skin.

Anti-Aging Research

Although aging is unavoidable, scientists continue to actively research different options for slowing down the overall process. According to researchers, there are 9 different hallmarks that are considered to be the main mechanisms of aging.[1]

All of these aging mechanisms are either pre-programmed in the DNA or caused by the accumulation of damage inside the cell. Both causes prevent cells from repairing, regenerating, or dividing.[2]

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What Are Anti-Aging Supplements?

Anti-aging supplements may slow down the aging process and increase longevity. Researchers have identified multiple compounds that can affect the processes which cause age-related deterioration of cells.

Anti-aging supplements contain natural chemicals that are widely researched by modern science. Most of these supplements are antioxidants that reduce free radical damage that affects the cell’s DNA, mitochondria, and other organelles.

How Do Anti-Aging Supplements Work?

Anti-aging supplements may protect various cellular structures from damage as well as improve other aspects of cellular health and integrity.

Some forms of anti-aging supplements must be taken orally and work through reducing the number of free radicals inside the body while improving the function of various organs and organ systems. Other anti-aging supplements are available in the form of gels or creams and work by alleviating the age-related damage done to your skin.

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What Are The Best Anti-Aging Supplements?

Resveratrol and Pterostilbene

Resveratrol is a polyphenol (antioxidant) that can significantly increase the lifespan in some animals according to several experiments.[3] This is most likely due to its effects on various genes that are related to mitochondria and aging.

Resveratrol can be found in foods including red wine, the skin of grapes, berries, peanuts, pistachios, and cocoa. Its recommended dosage is 100-500 mg daily.

Resveratrol can also be chemically transformed into a more potent derivate called pterostilbene. It affects the same mitochondrial genes and may be able to induce weight loss.[4] Pterostilbene may also be more effective than resveratrol in attenuating oxidative stress and cognitive decline related to the aging process. [5]

Fisetin

Fisetin is another polyphenol that has also been shown to increase the lifespan of some test animals.[6] It acts similarly to resveratrol and is found naturally in strawberries, apples, persimmons, and onions.

Fisetin has been investigated as a senolythic drug due to its ability to induce apoptosis (cell death) and selectively clear senescent cells.[7] There is currently a clinical trial being conducted in women that is investigating the effect of fisetin on age-related dysfunction.[8]

CoQ10

Coenzyme Q10 is one of the antioxidants that your body can produce on its own and it is essential for survival. Its main role is to aid the mitochondria in producing energy for the body and it can protect your cells against oxidative damage.

However, the natural synthesis of this antioxidant declines with age. Coenzyme Q10 might be effective in reducing the aging effect of oxidative damage and fighting the age-related decline in cardiovascular and physical performance.

Supplementation is particularly beneficial in people with heart disease as evidence suggests that CoQ10 can improve blood flow, endothelial function, and exercise capacity.[9] The bioavailability of CoQ10 heavily relies upon the presence of food and should be taken once daily in doses of 100-200 mg.

Collagen

Collagen is one of the most widely promoted anti-aging supplements due to its effects on the skin and ability to reduce the signs of aging. Collagen is the most abundant protein in the human body and is made of amino acids that support the structure of your skin, muscles, and bones.

Collagen is vital for skin elasticity and its roughness. Unfortunately, aging reduces the speed of collagen production and this leads to visible signs of aging, such as drier skin, reduced elasticity, and wrinkles.

Several scientific trials have shown that supplementation with 2.5 grams of collagen per day can increase its levels in the skin and reduce wrinkles. One of the studies showed significant improvements in skin hydration and elasticity after 8 weeks of supplementation, while another lasted for 12 weeks.[10] [11] Both studies were conducted in women.

Besides skincare, collagen supplementation might prove helpful in another aspect of aging – joint problems. One randomized trial showed great improvement in knee joint comfort and mobility in patients with osteoarthritis after 6 months of supplementation with 10g of collagen peptides.[12]

Anti-Aging Herbs

Turmeric

Turmeric owes its popular medicinal properties to the content of curcumin. Curcumin is an organic pigment with well-known anti-inflammatory effects on the body. According to numerous studies, these properties are especially notable in cases of osteoarthritis where curcumin significantly reduces pain and inflammation.[13]

Curcumin can also boost the overall number of antioxidants the body produces. Studies have suggested that supplementation upregulates the levels of at least 3 anti-oxidative enzymes (such as glutathione), reduces the levels of oxidative stress, and improves the lipid profile in people.[14]

Similarly to polyphenols, curcumin may stimulate the expression of sirtuins and improve mitochondrial function, which correlates with increased longevity in test animals.[15] It was found to increase the survival and lifespan of insects in animal studies.[16]

Normally, curcumin has poor absorption which is why it is often combined with black pepper extract, essential oils, or fats that boost bioavailability.

Rhodiola Rosea

Rhodiola Rosea is a herb with adaptogenic properties. It may reduce stress and fatigue, increase attention span, and enhance cognition.[17] It may also increase lifespan by activating genes involved in longevity.[18]

Studies show that Rhodiola effectively increases the lifespan of insects and other intervertebral animals by 10-20%.[19] The same mechanisms might also apply to other herbs that also increase stress-resistance, such as Ashwagandha and Ginseng, but to a lesser degree.

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What Vitamins are Good for Anti-Aging?

Vitamin B3 and Nicotinamides

Vitamin B3 (niacin), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) are all precursors for nicotinamide adenine dinucleotide (NAD+). NAD+ is a key factor in the energy metabolism of every cell in the human body and it’s also used to repair DNA as well as regulate key genes that play a role in cellular aging.

Supplementation with NAD+ may provide anti-aging benefits and evidence from animal studies shows that NR and NMN can significantly increase NAD+ levels in the body as well as potentially ameliorate age-related diseases.[20][21] One study in mice found out that NR can reverse the effects of aging on the liver and improve its functions.[22]

Vitamin C and Skin Aging

Vitamin C (ascorbic acid) is considered to be the most popular antioxidant in the world. It is often supplemented by people in an attempt to boost the immune system and aid the body’s defense against the common cold.

Studies have shown that Vitamin C reduces the risk of upper respiratory infection in athletes who participate in intense physical exercise.[23]

Vitamin C might play a key role in the healthy aging of skin alongside collagen. In fact, Vitamin C is the most abundant antioxidant in the skin and has an essential role in the healing of connective tissues. Without Vitamin C, collagen cannot form properly and this leads to a condition known as scurvy.

The recommended daily intake of Vitamin C is 100-200mg and should be taken orally in order for it to be effective. Unfortunately, Vitamin C is not very useful in topical skincare products since it is quickly oxidized by the air when exposed.

Benefits of Anti-Aging Supplements

Anti-Inflammatory Effects

Multiple ingredients in anti-aging supplements have anti-inflammatory effects. The most notable ingredients are curcumin and fish oil.

Studies on curcumin show a decrease in various markers of inflammation, such as tumor necrosis factor (TNF) and macrophage migration.[24] [25] Fish oil can also reduce inflammatory responses due to the effects of omega 3 fatty acids on the immune system.

Scientists have discovered that omega 3 can lower the levels of interleukin-2 (IL-2) amongst other inflammatory markers.[26] Some studies even suggest that fish oil and curcumin might have synergistic effects in attenuating inflammation.[27]

Insulin Sensitivity

Resveratrol is currently being investigated as an adjunct therapy to type 2 diabetes. One meta-analysis of 9 randomized trials and over 280 participants showed significant improvement of multiple markers for diabetes control.[28] The patients experienced lower insulin levels, insulin resistance index, and blood glucose levels.

Skin Health

Vitamin E also has benefits for skin health and may improve skin texture, reduce wrinkles, and alleviate skin damage due to UV light. The recommended dose of Vitamin E for skin protection is 400mg per day.

It’s important to use Vitamin E supplements that contain a mix of tocopherols since vitamin E consists of 8 different substances.

Another source of powerful polyphenols is green tea and its extracts. One study found out that the antioxidants in green tea also have a protective function against the aging effects of UV light on the skin.[29]

Heart Health

CoQ10 is present in every cell of the human body, however, its concentration is highest within the heart. Supplementation with CoQ10 improves mitochondrial function and the contractility of the heart muscle.[30] Furthermore, scientists suggest that CoQ10 may also reduce cardiac mass and improve heart function in patients with different heart problems.[31]

Brain Health and Cognition

The anti-inflammatory and anti-oxidative effects of curcumin may also extend to the brain. According to trials, these effects of curcumin can effectively attenuate the processes leading to age-associated cognitive impairment.[32]

Another pigment that might slow-down the age-related cognitive decline is crocin. Crocin is a yellow carotenoid that’s found within the most expensive spice in the world – saffron. Studies in rats have revealed that crocin attenuates oxidative stress, suppresses brain inflammation, and may even be effective in the prevention of age-related brain diseases, such as Alzheimer’s.[33]

Polyphenols and flavonoids are also well known for their beneficial effects on the central nervous system. Fisetin might provide benefits for brain health by inducing anti-inflammatory activity in brain microglia.[34] Researchers even speculate that it may be a potential therapeutic agent for the treatment of neuroinflammatory diseases.

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Side Effects of Anti-Aging Supplements

Most of the anti-aging compounds and vitamins discussed in this article have excellent safety profiles. Ingredients such as Rhodiola, fisetin, and pterostilbene do not have any established adverse side effects.

The most common adverse side effects of taking resveratrol, CoQ10, and curcumin are indigestion, flatulence, and diarrhea.

Excessive intake of Vitamin C may lead to hyperuricosuria and hyperoxaluria, thus increasing the risk of kidney stones.[35] Healthy individuals should generally avoid supplementing with doses over 250 mg.

Anti-Aging Supplements and Drug Interactions

Make sure to always seek medical advice before using anti-aging supplements. Most of the compounds used in anti-aging supplements have the ability to interact with the metabolism of various drugs which may lead to health complications.

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Do Anti-Aging Supplements Work?

There is an extensive amount of evidence that shows some antioxidants may significantly increase the lifespan of various test animals, however, whether this applies to humans as well is yet to be seen.

The majority of herbs and compounds found within anti-aging supplements that have antioxidative properties may aid the function of various organs and tissues, thus ultimately improving their overall function. This may reduce the aging process of the skin, brain, heart, liver, and other critical organs.

Best for Metabolic Health
Resveratrol Rapid + by Nuzena
1
Best Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging Supplements
Best for Metabolic Health
Resveratrol Rapid + by Nuzena

This capsule form of resveratrol provides natural antioxidant and anti-inflammatory support for helping to lower blood pressure, support healthy blood sugar levels, and promote longevity.

Capsule Form
2 Capsules Daily
Veggie Capsules
50% Trans-Resveratrol
$1.17/Serving
Best for Energy and Longevity
Energy by Performance Lab
2
Best Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging Supplements
Best for Energy and Longevity
Energy by Performance Lab

Energy provides superior mitochondrial support for cell energy and vitality through the use of MicroActive® Q10, BioPerine®, BioPQQ® and Bio-Enhanced® nutrition technology.

Capsule Form
2 Capsules Daily
Vegan Friendly
5 Potent Supplements
$1.63/Serving
3
Best Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging SupplementsBest Anti-Aging Supplements
Best for Wrinkles
Collagen Peptides by Essential Elements

This product contains hydrolyzed, type I & III Collagen peptides that are sourced from grass-fed, pasture-raised, Grade A bovine.

Powder Form
1 Scoop per Serving
Keto Friendly
Grass-Fed Bovine
$0.73/Serving

References

See all references
[1] https://www.ncbi.nlm.nih.gov/books/NBK10041/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/
[3] https://pubmed.ncbi.nlm.nih.gov/27781945/
[4] https://pubmed.ncbi.nlm.nih.gov/25057276/
[5] https://pubmed.ncbi.nlm.nih.gov/21982274/
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405395/
[8] https://clinicaltrials.gov/ct2/show/NCT03430037
[9] https://pubmed.ncbi.nlm.nih.gov/16882678/
[10] https://pubmed.ncbi.nlm.nih.gov/24401291/
[11] https://pubmed.ncbi.nlm.nih.gov/31627309/
[12] https://www.tandfonline.com/doi/abs/10.1080/09637480802498820
[13] https://pubmed.ncbi.nlm.nih.gov/24853120/
[14] https://pubmed.ncbi.nlm.nih.gov/23013352/
[15] https://pubmed.ncbi.nlm.nih.gov/24755072/
[16] https://pubmed.ncbi.nlm.nih.gov/30488487/
[17] https://pubmed.ncbi.nlm.nih.gov/11081987/
[18] https://pubmed.ncbi.nlm.nih.gov/18536978/
[19] https://pubmed.ncbi.nlm.nih.gov/24472572/
[20] https://pubmed.ncbi.nlm.nih.gov/31511627/
[21] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842119/
[22] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717504/
[23] https://pubmed.ncbi.nlm.nih.gov/23440782/
[24] https://pubmed.ncbi.nlm.nih.gov/9586949/
[25] https://pubmed.ncbi.nlm.nih.gov/25369140/
[26] https://pubmed.ncbi.nlm.nih.gov/9040541/
[27] https://pubmed.ncbi.nlm.nih.gov/19744468/
[28] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610395/
[29] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412948/
[30] https://pubmed.ncbi.nlm.nih.gov/15632821/
[31] https://pubmed.ncbi.nlm.nih.gov/19096110/
[32] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964053/
[33] https://pubmed.ncbi.nlm.nih.gov/29299203/
[34] https://pubmed.ncbi.nlm.nih.gov/18279803/
[35] https://jamanetwork.com/journals/jama/article-abstract/189543

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