LGD 2226 Review

LGD 2226, one of the experimental SARMs, was initially developed to treat osteoporosis and muscle wasting. With more ongoing research on the SARM, more benefits have come into light as people have reported increased stamina and endurance. Read more to know everything about LGD 2226 which is still an underresearched SARM at the moment.

Class of Compound

SARMs

Mechanism of Action

LGD2226 is a selective agonist for androgen receptors and binds specifically in muscle and bones. It also mimics the action of testosterone and supports muscle building and endurance, giving you a perfect shape.

Street Names

Quinolinone

Effects

Increased lean muscle mass, enhanced bone density, greater stamina, boosts endurance

Side Effects and Dangers

Rare side effects

Chemical Structure

If you are an athlete, a bodybuilder, or someone from a fitness background, one of the most common problems that you would be facing is muscle wasting. 

The intense workout schedules augmented by dedicated training for your particular sports can be daunting as your muscles experience intense strain and are more prone to be wasted and lose mass and shape. 

In order to cater to this drawback and offer enhanced benefits to people involved in fitness, SARMs like LGD 2226 are developed and marketed. 

SARMs, abbreviated for Selective Androgen Receptor Modulators offer tremendous benefits just like anabolic steroids such as muscle building, increasing lean muscle mass, and promoting fat loss with minimal side effects which is one of the strong reasons why the bodybuilding community prefers them over anabolic steroids. 

Cut to the chase, today we are talking about LGD 2226, an experimental SARM that is mildly popular at the moment but needs more clinical research before it can create noise in the community. This LGD 2226 review include everything you need to know about this SARM before making a decision for yourself whether to use LGD 2226 or not. 

What is LGD 2226? 

LGD 2226 is an orally active Selective Androgen Receptor Modulator (SARM) that is still in the experimental phase (1). 

LGD 2226 Review
Figure 1: LGD 2226

Perhaps it was first developed to combat muscle wasting and manage and treat osteoporosis. Since its inception, it has been a part of multiple clinical trials and is still being researched before it can be legally introduced into the market. 

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How Does LGD 2226 Work? 

Just like other SARMS, LGD 2226 also acts as a potent agonist of the androgen receptors, particularly located in bone and muscle tissues. The subsequent binding of LGD 2226 with androgenic receptors results in anabolic effects in both muscles and bones (2,3).

In this way, LGD 2226 mimics the action of testosterone and supports the building and bulking of muscles. Perhaps what makes LGD 2226 an ideal SARM is its reduced effects on the prostate, thus making it a safer option (4). 

Benefits of LGD 2226 

Binding to the androgen receptors implies that you will experience anabolic effects by having increased lean muscle mass with much bigger gains and altered body composition. Not only this, but it also prevents muscle wasting which is one of the reasons why it was developed and is vouched as a potent SARM (4). 

Because it also binds to the androgen receptors on bone, you can also expect enhanced bone density and strengthening of bones, thus managing and treating osteoporosis (4). 

LGD 2226 makes sure that lower levels of testosterone are never a hurdle, thus you will enjoy much greater stamina and endurance. You will also be able to perform intense workout sessions and expect a faster recovery post-workout session. This will enhance your overall workout regime and make your bodybuilding and fitness journey more fruitful.  

Owing to the anabolic nature of LGD 2226, research suggests that it is effective in burning fat and triggering weight loss, thereby giving you a perfect shape. 

Some research also suggests that it may elevate the levels of testosterone in the body in people suffering from testosterone deficiency. 

Is LGD 2226 Legal?

No, it is not legal at all to sell, or use LGD 2226 anyways. You will find a lot of stores claiming to sell authentic and original LGD 2226 but remember to verify everything before making any purchase. 

This SARM still needs to undergo dedicated clinical research in order to know about the potential benefits and long-term efficacy and safety. 

LGD 2226 Dosage 

Note that there are no general guidelines on the appropriate and optimal dosage of LGD 2226. Because the SARMs is so new and no anecdotal evidence is available yet, it is hard to suggest any dosing. This is worsened due to the fact that no human studies have been done.

The pharmacokinetics suggest that the half-life of LGD 2226 is around 25 to 30 hours, thus one dosage a day will surely be enough.  

Forms of LGD 2226 Available

LGD 2226 is commonly available as tablets and capsules. After skimming through the internet, I saw that some online vendors also offer powdered form. 

How To Use LGD 2226? 

LGD 2226 can be used orally. You may want to use it with water or juice to ensure better bioavailability. 

LGD 2226 Side Effects 

It can be inferred from the limited clinical studies available that this SARM is definitely a safer option to use. This is because it doesn’t affect the prostate gland, thus minimizing the risk of developing any major complication. 

Nevertheless, the long-term safety profile of this SARM needs to be extracted before really making it public. 

LGD 2226 User Reviews

The lack of sufficient clinical studies means that SARM users definitely look for much better and safer alternatives before anything solid on LGD 2226 comes. 

I still tried to look for people’s experiences with LGS 2226 on Reddit and what i can understand is people have stacked LGD 2226 with other potent SARMs and have witnessed much better results as far as their bodybuilding and fitness gains are concerned. 

LGD 2226 Stacks 

Although uncommon some users on Reddit have discussed stacking LGD 2226 with LGD 3033 and LGD 4033

The limited experiences suggest that this stack has improved muscle memory and has been effective in giving muscle pumps, thereby ensuring that you are all geared up to lift much stronger weights with much better endurance. 

Where To Buy LGD 2226? 

The fact that it is still an experimental product makes it a rather unavailable SARM. But you will still find some online vendors claiming to sell an authentic version of LGD 2226. 

If you really want to start using it, make sure to make your purchase from any well-known and reputable vendor but beware of any scams! 

LGD 2226 vs Other Compounds

LGD 2226 vs LGD 3303 

LGD 3033 is also a potent SARM with both anabolic and androgenic effects. But this SARM is a partial agonist rather than a full agonist of the androgen receptor modulators.

It was also originally developed as a prospective treatment for osteoporosis. 

LGD 3303 has a much better oral bioavailability and animal models suggest that it has the capability to increase the efficacy of bisphosphonate drugs.  

LGD 2226 vs LGD 4033

LGD 4033 is a much more potent SARM with enhanced anabolic and androgenic properties. 

It comes into the category of non-steroidal oral SARM and offers much greater benefits to bodybuilders and fitness pros in terms of their gains. 

Just like other members, it was also originally introduced in the market to treat osteoporosis and muscle wasting. 

Is LGD 2226 Legit? 

To be very honest, I wouldn’t really recommend using LGS 2226 at the moment because of very obvious reasons. 

Limited clinical trials, as well as insufficient user experiences, mean that one can’t always predict this SARM. 

Perhaps you can always have better and highly used alternatives available in the market till more research is available and people actually start noticing the effects. 

FAQs about LGD 2226 

What does LGD 2226 do?

LGD-2226 is an investigational selective androgen receptor modulator (SARM), which is being developed for the treatment of muscle wasting and osteoporosis.

What are the side effects of taking Ligandrol?

The typical side effects of anabolic steroids can include short-term aggression and violence, acne, and sleeping difficulties, and long-term effects such as damage to the liver and kidneys, depression, and high blood pressure.

Is LGD androgenic or anabolic?

LGD-4033 is a novel nonsteroidal, oral SARM that binds to the androgen receptors with high affinity (Ki of ∼1 nM) and selectivity. In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and a robust selectivity for muscle versus prostate.

How long does LGD 2226 stay in the body? 

It has a half-life of approximately 25 to 30 hours inside the body. 

1)https://pubchem.ncbi.nlm.nih.gov/compound/lgd-2226

2)https://pubmed.ncbi.nlm.nih.gov/34714606/

3)https://pubmed.ncbi.nlm.nih.gov/17034117/

4)https://pubmed.ncbi.nlm.nih.gov/17023534/

Kartik Kumar Rathi

Kartik is a Doctor in training currently in his second year of medical school with the ultimate goal of becoming a successful cardiologist, he currently contributes to health blogs, research papers and also founded a social health startup to help educate others.

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