5 Best Probiotics for Leaky Gut

The leaky gut syndrome is caused by undigested proteins and bad bacteria leaking into our bloodstream, eliciting an immune reaction. 

This can result in widespread systemic inflammation, leading to numerous health problems like chronic fatigue, eczema, Irritable Bowel Syndrome(IBS), depression, anxiety, and a lowered ability to digest food with decreased absorption of nutrients. 

I’m not sure if I got leaky gut syndrome since it’s hard to test and confirm it. However, I had symptoms such as bad skin, IBS, and depression, all associated with the abovementioned disorder.

With the symptoms getting quite uncomfortable and difficult to deal with, I switched to probiotic supplementations. And I might say it was one of the best decisions. With probiotics, I felt much better and healthier. 

Here are the top 5 probiotics for the leaky gut syndrome, in my opinion.

BEST Probiotics for Leaky Gut Reviewed

#1 Choice: Seed Probiotic

This premium quality probiotic offered by SEED ensures your gastrointestinal health, and helps alleviate Leaky gut syndrome with a healthy body.  

These ALL-in-ONE probiotic capsules are formulated with 24 clinically tested specific strains and ingredients. Some of them beneficial for GUT health are Bifidobacterium longum, Bifidobacterium breve, Lactiplantibacillus plantarum. Lacticaseibacillus rhamnosus, Lacticaseibacillus rhamnosus, Bifidobacterium infantis, Bifidobacterium lactis, Lactobacillus crispatus.. 

Seed products measure the AFU or active fluorescent units instead of just the CFU that most manufacturers measure. AFU is a more exact science that gives customers more accurate information about cell viability. This allows Seed to know more about the effects of their products and how they can benefit major systems within the body.

All the strains work synergistically to strengthen your gut immune function, allow micronutrient synthesis in your body, keep your cholesterol in check, and strengthen your GUT immunity. The daily Gut Barrier Integrity Probiotic Blend comprises 37.0 billion AFU for gastrointestinal health. 

With so much considered by the scientists of SEED, the daily synbiotic is formulated by considering the Vegans. Not only this, it is gluten-free, dairy-free, soy-free, and much more, with zero preservatives added! 

Besides, with much engineering going into making the product and carefully considering the climate, the product is made with a precise amalgamation of the outer Prebiotic capsule and inner Probiotic capsule. Thus, when you are ordering again, all you need to do is order sustainable refills. 

SEED offers premium quality probiotic capsules to optimize your overall health experience and help maintain your GIT lining.  
Read the Full Review


  • 100% Vegan
  • Free of Allergens and Preservatives
  • No refrigeration required
  • Contains 53.6 Billion AFU


  • Requires subscription
  • Proprietary formula
  • May experience gastrointestinal sensitivity

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Physician’s Choice 60 Billion Probiotic

best probiotic brand for leaky gut

The Physician’s Choice 60 Billion probiotic is number 1 for a reason, it’s by far my favorite probiotic of all time, as it totally cured me and gave me my life back.

Before finding the Physician’s Choice probiotic I had tried many, but it seemed the problem was that none of them were potent enough or had quite enough probiotic strains.

The Physician’s Choice has 10 probiotic strains totalling to 60 billion CFUs (healthy bacteria) per capsule, which is quite spectacular.

I also really like the fact that this probiotic is actually Physician approved and is 100% free of GMOs, in addition it comes at an incredibly affordable price point, which is another definite plus in my opinion.

5 Best Probiotics for Leaky Gut

BioSchwartz Probiotic

probiotics for leaky gut

The second probiotic, although not nearly as potent or effective as Physician’s Choice probiotic is BioSchwartz.

BioSchwartz has been around for a very long time and they have hundreds of reviews on their famous Advanced Strength Probiotic. The probiotic has 40 billion CFUs (healthy bacteria) per capsule coming from 4 different probiotic strains.

The probiotic strains include: 

  • Bifidobacterium lactis,
  • Lactobacillus acidophilus,
  • Lactobacillus plantarum,
  • Lactobacillus paracasei

Out of the strains listed I’m a big fan of Lactobacillus acidophilus, as it’s a well researched probiotic strain and proven to be very beneficial for boosting the immune system and healing the gut.

Even though BioSchwartz is on the pricier side, as you need to take 2 capsules daily, it’s still a solid choice.

5 Best Probiotics for Leaky Gut

Culturelle Daily Probiotic

best probiotics for leaky gut

The 3rd best probiotic for leaky gut is definitely Culturelle’s Daily probiotic, its unique advantage is that it comes with a proven prebiotic, inulin.

Prebiotics are essentially little helpers that help with the absorption of probiotics, making them far more efficient and beneficial to the body.

Culturelle’s Daily probiotic contains only a single strain, Lactobacillus rhamnosus, the strain has been proven to be effective with IBS symptoms, especially in children.

It’s also been proven to be a great probiotic strain for treating diarrhea caused by antibiotic consumption.

Another benefit of Culturelle is that their probiotic is quite affordable, but unfortunately, it does only contain that single probiotic strain, which I’m not really a fan of.

5 Best Probiotics for Leaky Gut

UP4 Adult Probiotic

probiotic for leaky gut

Even though all the probiotics listed above are vegan, this one goes even a step further.

The UP4 Adult probiotic is 100% certified vegan and like the rest of the probiotics, also 100% FREE of dairy, gluten and soy.

The UP4 daily comes with 5 billion CFUs (healthy bacteria) per capsule, coming from only 2 probiotic strains:

  • Lactobacillus acidophilus
  • Bifidobacterium longum

Even though both of these probiotic strains are quite good, I was a bit disappointed that the probiotic strain and CFU counts are super low, which makes me doubt about how potent this probiotic really is.

According to the positive reviews, people are seeing benefits from taking it though, so that’s all that matters.

5 Best Probiotics for Leaky Gut

Hyperbiotics Pro 15 Probiotic

best probiotic supplement for leaky gut

Hyperbiotics Pro 15 is a popular probiotic that contains 15 different probiotic strains and 5 billion CFUs per capsule, which is quite impressive.

The probiotic strains include:

  • L. fermentum
  • L. acidophilus
  • L. casei
  • B. longum
  • B. lactis
  • L. rhamnosus
  • L. plantarum
  • B. infantis
  • Lactobacillus
  • Bifidobacterium
  • Streptococcus

To get the promised results and heal your leaky gut you just need to take a single capsule per day, ideally before a meal with water.

Alongside this probiotic healing your leaky gut you can also expect improved mental clarity, more energy and a boost in your immune system.

5 Best Probiotics for Leaky Gut

What is a leaky gut syndrome, and is it real? 

Leaky gut syndrome, also known as intestinal hyperpermeability, has gained the attention of many people associated with medicine, especially natural health enthusiasts. However, there is a lot of controversy around this term, and some medical practitioners even deny the existence of this condition. 

Nonetheless, several other medical blogs and articles suggest that this condition might be the root cause of certain chronic gastrointestinal and systemic disorders. So what does leaky gut mean, and what causes it in the first place? 

Leaky gut syndrome/intestinal hyperpermeability is when your gut lining is disrupted, and several harmful substances like undigested food, bad bacteria, etc., can leak into your bloodstream. 

Your intestinal lining is made up of epithelial cells attached through tight junctions. These tight junctions make your gut lining semi-permeable and thus only allow specific substances to pass through. However, harmful substances can make their way to your bloodstream with a damaged gut wall, resulting in systemic inflammation and immune reactions. 

According to Healthline, zonulin, a protein, is the key regulator of intestinal permeability, and bacteria and gluten trigger its release. Nonetheless, other factors might also result in leaky gut syndrome. Such as: 

  • A diet rich in sugar
  • Prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) 
  • The deficiency of vitamin A and D, along with zinc, can also increase intestinal permeability
  • Inflammation and 
  • Dysbiosis, i.e., imbalance in gut microflora 

According to an article, the common symptoms to look for in leaky gut syndrome are 

Chronic diarrhea, gas, bloating, headaches, excessive fatigue, skin rashes such as acne and eczema, arthritis, etc.  

What diseases are associated with leaky gut syndrome? 

There’s a lot of contradiction correlated with the leaky gut syndrome and whether it is a cause or symptom of a disease. 

Nevertheless, leaky gut is associated with several other chronic diseases, and it’s worth mentioning them here and gaining more insight into this medical mystery. 

Celiac disease: This disorder results from increased sensitivity to gluten. As mentioned above, gluten triggers the release of zonulin, which increases intestinal permeability. 

Crohn’s disease: Increased intestinal permeability can result in persistent gut inflammation, characteristic of Crohn’s disease. 

Diabetes: A Lot of controversy lies with this disorder. Researchers suggest that the leaking of harmful substances resulting from a leaky gut can result in an immune reaction responsible for beta cell destruction in the pancreas, cells that release insulin. 

Other than the above-mentioned, disorders such as Irritable bowel syndrome, fibromyalgia, food allergies, and acne are also associated with the leaky gut syndrome. 

Can probiotics be used with leaky gut syndrome? 

As mentioned above, it is believed that dysbiosis can be a cause that can lead to a leaky gut. An imbalance between good and bad bacteria in your gastrointestinal tract can worsen your gut problems and may lead to disrupted intestinal walls. 

It is hypothesized that modulating the gut microflora can help heal the gut’s disrupted and inflamed epithelial lining and help reduce intestinal permeability. 

According to Dr. Michael Ruscio, a holistic approach accompanied by probiotic supplementation can be a potential tool for leaky gut and alleviating its consequences. According to him, probiotics help restore the bacterial balance in your gut, simultaneously healing the intestinal lining and reducing inflammation. 

Several clinical evidence suggests that the intake of probiotics with multiple bacterial strains improved intestinal permeability. 

One such clinical study suggested that a 14-week long supplementation with probiotics decreased zonulin production. A trial even suggested that Lactobacillus Rhamnosus showed beneficial effects on genes that regulated gut permeability.

Which probiotic blends are beneficial for leaky gut syndrome? 

It is often suggested to take a course of a multi-species probiotic blend for maximum benefit and maintenance of a healthy gut lining. However, it gets quite perplexing when deciding which ones can reverse intestinal hyperpermeability. 

Many clinical studies suggest that the best blend consisting of Lactobacillus and Bifidobacterium strains is the right option. 

These strains aid in a healthy inflammatory response and create a balanced bacterial flora in your gastrointestinal tract. 

Why is DS-01 Daily Synbiotic by SEED the best Probiotics to be used?

Probiotics offered by SEED are beneficial in almost every aspect of your body. SEED provides the best probiotic formula laden with multiple bacterial strains, whether your dermatological health or your cardiovascular system, to your gastrointestinal tract. 

Leaky gut syndrome and the associated consequences of this disorder is predominantly related to your Gut. These can be managed with SEED’s 37.0 Billion AFU. It assists in your digestive health as well as your gut immunity. 

Probiotics offered by SEED are thoroughly tested and ensure that it doesn’t cause any adverse side effects. With its prebiotic capsule, one can have a more competent method of combating this disease.

Briana Perkins

My name is Briana, I’m 33 years old and come from Los Angeles. Born and raised. 🙂 I have 2 kids, 2 energetic boys… Jack who’s 10 and Tom who’s 6 years old. Luckily I’m a stay at home mom, otherwise, I’d have no clue how I’d manage. In my free time, I like to play tennis, run and educate myself on health and the best supplements.

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