Semax: Peptide Nootropic, Side Effects + Benefits + Buy

N-Acetyl-Semax Acetate is a derivative of Semax but with better bioavailability and strength. It improves mental functioning, helps manage cerebral stroke, and acts as a potential antidepressant.
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

If you are a fan of nootropics, or maybe, you are someone who is just a beginner and doing some internet surfing on the effective and well-researched nootropics available in the market at the moment, then I am sure you must have come across a therapy called Semax.

Not only do the users of Semax manifest cognitive advancement, but it also acts as an antioxidant in the body and improves microcirculation in the body.

I know it sounds very promising, and you want to know more, trust me, I got you!

This article will include everything you need to know about Semax, the potential derivatives of Semax available, and the benefits as well as side effects, if any.

Hopefully, you will be able to decide by the end of the article whether Semax or any of its derivatives is an ideal nootropic for you or not.


  • Enhanced cognitive benefits
  • Antidepressant and anxiolytic
  • Manages cerebral stroke


  • Hair loss
  • Lack of pharmacodynamics on how the drug interacts with pre-existing conditions

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

What is N-Acetyl-Semax Acetate?

Before knowing what N-Acetyl-Semax Acetate is, it is important to understand the background of the parent drug, which is Semax.

The Russian-developed drug called Semax (1) is a peptide comprising 7 amino acids (Met-Glu-His-Phe-Pro-Gly-Pro). Semax is structurally analogous to the Adrenocorticotropic hormone (ACTH). What this means is that it is a small fragment of peptide extracted from the big chain of amino acids that make up ACTH.

The potential nootropic and neuroprotective properties of Semax have compelled researchers to carry out detailed studies on it, which led to the development of many sub-types of Semax, such as N-Acetyl-Semax Acetate, N-Acetyl Semax Amidate, and Adamax.

With minor differences in the structure of the parent drug and its derivatives, there are significant differences in efficiency and efficacy.

N-Acetyl-Semax Acetate is perhaps 3 amino acids short of the original Semax, which gives it a longer half-life as well as potency.

How Does N-Acetyl-Semax Acetate Work?

N-Acetyl-Semax Acetate follows multiple courses of action to affect the functioning of the body at various levels.

Because it is structurally analogous to ACTH, there is no surprise that it also mimics its action.

The primary areas where the drug expresses itself are the hippocampus, limbic reticular complex, and some of the other peripheral receptors.

The major way in which N-Acetyl-Semax Acetate works is by upregulating the release of brain-derived neurotrophic factor (BDNF) from the hippocampus (2).

N-Acetyl-Semax Acetate also increases the levels of tropomyosin receptor kinase B (TrkB). BDNF and TrkB work hand in hand to pose the effects.

Research suggests that N-Acetyl-Semax Acetate acts as a potent agonist of the melanocortin receptors found in the skin (3).

Being a strong nootropic, it is obvious that N-Acetyl-Semax Acetate increases dopamine and serotonin levels, the two big players in cognitive enhancement (4).

Evidence suggests N-Acetyl-Semax Acetate increases the enkephalin levels in the body. Enkephalins are small peptides responsible for minimizing the feeling of pain.

Benefits Of N-Acetyl-Semax Acetate

Research suggests a strong negative correlation between BDNF levels and the frequency of mental disorders, such as depression, anxiety, PTSD, etc. As N-Acetyl-Semax Acetate increases BDNF levels, it potentially acts as an antidepressant and anxiolytic drug.

Increased levels of BDNF possess neuroprotective properties, which means that it enhances neuronal growth and amplifies synaptic/neuronal plasticity. This helps in forming strong neural connections in the brain, which aids in memory and learning (5).

Clinical trials show that you can recall better and focus as well as concentrate well if optimal dosages are taken.

N-Acetyl-Semax Acetate alleviates stress levels and keeps you under the ice in tough moments. This overall improves mental clarity as well as communication abilities in individuals.

Originally Semax was developed to manage cerebral ischemia, which is the insufficient supply of blood to certain microcirculatory areas of the brain (6).

Semax is known to improve microcirculation and minimize the risk of developing hypertrophy of the heart by significantly reducing blood pressure levels.

Because Semax decreases the breakdown of enkephalins, it helps in reducing the pain sensation.

The elevated dopamine and serotonin levels will help in making you feel productive, alert, and motivated to perform tasks. It will enhance your mood and make you feel fresh.

Some studies also show that the nootropic acts as a potent antioxidant. It greatly reduces the oxidative stress felt by certain body parts (7).

Although unclear, some studies also suggest an improvement in physical performance, athletic abilities, and enhanced endurance after consuming N-Acetyl-Semax Acetate.

While the Russian-developed drug is widely available to be used in Russia and Ukraine, the FDA has not approved its usage yet.

It is still a regulated drug and needs to be researched more before the FDA approves it.

Who Can Use N-Acetyl-Semax Acetate?

People who are looking for nootropics to enhance their mental capabilities can surely try N-Acetyl-Semax Acetate. If you want to manage your depression and anxiety, perhaps N-Acetyl-Semax Acetate can do the job!

If your doctors prescribe it, you can also use the drug to manage your stroke-related symptoms.

Forms Of N-Acetyl-Semax Acetate

The nootropic was originally developed in the nasal spray form, but with more research and development surrounding the product lately, you will also find injectable forms in the market.

While both forms are equally strong, I would suggest considering the pioneer nasal spray form owing to the potency of the nootropic as well as the increased bioavailability.

How To Use N-Acetyl-Semax Acetate

Once your dosage and preferred form of intake are in place, all you have to do is make sure that you consume it in the right way.

The spray form should be used intranasally, with special attention paid to the number of times you press the knob. It will depend on your dosage guidelines.

On the other hand, if you are going for the injectable form, you should inject it subcutaneously, which means under the skin. It will ensure that the nootropic reaches its prime target right in time.

N-Acetyl-Semax Acetate Dosage

Your dosage will largely depend on your reason for intake.

A typical dosage anywhere between 200mcg to 900mcg seems to work well with the users. What I always recommend is to start low for a couple of days, and when your body starts acclimatizing, you can go higher.

The optimal dosage of 600mcg to 800mcg per day can surely help you experience the benefits you are craving for!

But, if your reason for intake is more on the treatment side, such as managing stroke, then the human-based studies suggest an optimal dosage of 500mcg.

N-Acetyl-Semax Acetate Cycle

What I like about the potent nootropics is that they rarely develop an addiction in humans or don’t require post-cycle therapy (PCT).

Because of this reason, you can continue the N-Acetyl-Semax Acetate regularly and can stop it whenever you feel like it.

N-Acetyl-Semax Acetate Stack

If you had heard about Semax anytime in the past, I am sure that you must have also heard about the twin-nootropic Selank (8).

While N-Acetyl-Semax Acetate is itself very strong, stacking it with Selank can change the game.

You will experience the antidepressant, anxiolytic, and therapeutic effects on your just first dose. The Semax/Selank stack will offer you enhanced cognitive benefits and improved proprioception.

This stack will offer you supplemental benefits, such as an improved immune system with strong inflammatory reactions.

You might also experience better musculoskeletal performance.

N-Acetyl-Semax Acetate User Experiences

It is important to know about the personal experiences of people who have used the nootropic to get a clearer picture of what to expect.

One of the in-depth reviews by an anonymous person stated,

“Hello, I would like to post my experiences with NA SEMAX and NA SEMAX Amidate (NASA.) First and foremost, I have nothing but positive to say about these two peptides. They have helped me get through some tough times…

Increase in memory retention, slightly improved motor function, I noticed a great decrease in my anxiety levels, Slightly less sexual, and amazing creativity results.”

Brian Mathews says,

“I am quite impressed by these Semax and Selank Amidate. They have lifted my depression and have made my performance at work better. I highly recommend trying them out.”

However, Louie didn’t have the expected experience. He said,

“Well, I’m now at 4 sprays a day. 2 in the morning and 2 later in the afternoon. Still haven’t noticed anything that I could tell.”

πŸ’‰Become a Peptide Expert (Protect your Health) πŸ’‰

Take our FREE 25-email course to learn everything you need to know about the scientific application of peptides. Discover how to protect your health, avoid sketchy peptide vendors, and stop wasting your hard-earned money. πŸ”₯ πŸ§ͺ πŸ’Š πŸ’ͺ πŸ’‰ 🩸πŸ₯ πŸ₯Ž

Best Time To Take N-Acetyl-Semax Acetate

There isn’t anything related to an ideal time to use the nootropic. But considering the half-life, which is 2 to 10 hours, I would suggest taking it an hour before you start your day. In this way, the drug will kick in well and start showing effects.

N-Acetyl-Semax Acetate Side Effects

This N-Acetyl-Semax Acetate is generally considered safe and doesn’t pose any significant adverse effects on the body.

Some users have demonstrated hair loss. This is understandable because elevated levels of BDNF promote hair follicles to grow (9).

People suffering from any chronic mental/nervous conditions must avoid using this nootropic as the latter may not interact well enough with the pre-existing condition.

But that’s pretty much it in terms of side effects!

Where Can I Buy N-Acetyl-Semax Acetate?

It is important to know the right places to buy authentic products, so we at Muscle and Brawn always make sure to give you premium yet economical suggestions, and I would recommend you buy Semax/N-Acetyl-Semax Acetate from Pure Rawz.

Semax Overview and Where to Buy

Semax, often categorized with Peptides, is primarily recognized as a nootropic peptide. It enhances cognitive functions by stimulating the release of brain-derived neurotrophic factor (BDNF).

This is a desirable effect for those aiming to boost cognitive performance, and this is why Semax is gaining traction among biohackers and cognitive enhancers. It’s essentially a method of brain optimization. [1,2]

Whether you’re aiming to enhance memory, focus, or even mental agility, optimizing brain function can be immensely beneficial.

Semax aids in balancing neurotransmitter levels in the brain. Thus, it ensures optimal brain function and communication between neurons.

Maintaining balanced neurotransmitter levels can prevent cognitive decline and other brain-related issues. Those in the cognitive enhancement community also recognize that imbalanced neurotransmitter levels can lead to issues like brain fog, memory lapses, and decreased mental agility.

Semaglutide Overview

⭐️ Top Benefits: Increases glycaemic control and decreases hunger
πŸ§ͺ Form: Injectable liquid
βŒ›οΈ Max Time Used: 6 – 8 Weeks
πŸ’° Average Cost: $119.99
β€οΈβ€πŸ©Ή Side Effects: Allergic reaction
☒️ Dangers: Allergic reaction
πŸ“š Best Peptide Stack: HGH / IGF-1 / HGH-Frag
⚀ Men/Women: Men and women

  • Increases insulin control
  • Decreases hunger
  • Pain at the injection site
  • Allergic reaction

N-Acetyl-Semax Acetate VS. Selank

While both are developed in Russia, N-Acetyl-Semax Acetate is a nootropic that is particularly used to enhance cognitive functions. It assists individuals to achieve more mental clarity and optimal concentration levels. It is a neuroprotective as well as a neuro-stimulating peptide.

Selank is more commonly used for anxiolytic effects. While it also offers similar benefits to Semax, the medical/therapeutic use of Selank is more pronounced. Selank offers a lot in terms of immune functioning and enhanced inflammatory reactions (10).

The mechanism of action of both nootropics seems quite similar.

It is important to note that there are structural differences as well. Semax is a derivative of the endogenous peptide ACTH, while Selank is an elongated version of Tuftsin, a naturally occurring peptide found in IgG immunoglobulins.

Selank/Semax stack is more commonly used to avail maximum synergistic benefits.

Is N-Acetyl-Semax Acetate Legit?

For sure, Yes!

It seems very effective to me after going through all the information about how it works and the personal experiences of people.

N-Acetyl-Semax Acetate triggers the brain centers on the point and significantly alleviates depression and anxiety in individuals.

It can improve your mental capabilities and help you surpass your cognitive expectations within no time. With nearly no side effects, the scientific evidence suggests volumes about the neuroprotective and nootropic benefits of N-Acetyl-Semax Acetate.

FAQs on N-Acetyl-Semax Acetate

What is Semax Acetate?

Semax is an experimental drug developed in Russia to prevent and treat circulatory disorders. It has also been identified as a “nootropic.”

What is Semax peptide used for?

Semax has been prescribed for anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal, and even chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s. Semax has been known to be used as an Adderall alternative.

Is Semax a peptide?

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic peptide consisting of a fragment of ACTH(4–7) and the C-terminal tripeptide Pro-Gly-Pro (PGP).

What is the half-life of N-Acetyl-Semax Acetate?

The pharmacokinetics suggest that the half-life is around 2-10 hours.

Which is more effective, Semax or its derivatives?

Recent studies suggest that the derivatives such as N-Acetyl Semax Acetate and N-Acetyl-Semax Amidate possess more bioavailability and potency.

What is N-Acetyl Semax Amidate (NASA)?

N-Acetyl-Semax Amidate is considered the best version, probably because it is the most modified form.

Comments and questions?

Join our closed Facebook group and get custom answers from the community.

Drop us a commentΒ down belowΒ and one of our expert coaches will respond to it.



Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

Read all articles
Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
Notify of

Inline Feedbacks
View all comments

EliteHRT Sign Up

Anti-Aging, Peptide, and Health Science Delivered to Your Inbox

Join 14,000 readers keeping informed and staying up to date on all of the latest Peptide, TRT, and SARMs news, in only 5 minutes per week.

Don't like emails?

Join our Facebook group and get the same updates!