5 Best Peptides For Female Fat Burning

Peptide therapy is one of the emerging therapeutic ways to achieve increased fat burning. Most of these peptides work by altering the natural hormone production in the human body, and are generally considered safe. Read more to know the top 5 peptides for female fat loss!

Life, huh? Working an 8 hour day, gym for another 60 minutes, then you still need to clean, cook, socialize, get ready, and commute to work? That sounds about as fun as getting a full-body wax – I’m not sure how fun that is in reality but my girlfriend says it sucks.

Supplements have been taking advantage of people and their hard-earned money for quite some time; pixie dusting and false promises have made us all want something a little stronger; or at least something that works.

Peptides were invented to treat specific medical conditions such as Obesity. We can get our hands on some of these as ‘research peptides’ to help us shed a few pounds as long as we still train and eat correctly. But which ones are best and how do you actually get them?

Luckily for you, we’ve got all the answers.

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways

  • Peptide therapy is one of the effective ways when it comes to rapid fat loss. 
  • Five of the finest and safest peptides for fat loss, especially indicated in females, include CJC 1295, Semaglutide, Sermorelin, 5-Amino-1MQ, and Tirzepatide. 
  • Most of these work by increasing the production of human growth hormone, reducing appetite, effective glucose metabolism, and inhibiting (NNMT) enzymes.

What Are The Best Fat Loss Peptides?

Semaglutide Summary

Semaglutide (GLP-1)

Semaglutide gets grouped with other Peptides but is more commonly known as a GLP-1 receptor agonist. It mimics the action of human incretin glucagon-like peptide-1 (GLP-1).

This is something that you would want when trying to lose weight, and this is why Semaglutide is being used as an anti-obesity medication (combined with a good diet and training plan). It is simply a method of glycemic control.

When trying to lose weight or even trying to increase weight dramatically (bulking), glycemic control could help a tremendous amount.

Semaglutide will help your pancreas release the right amount of insulin when your blood sugar is high. So, it helps your body produce the correct amount of insulin needed.

This can help you avoid chronically high levels of blood sugar, which can have some severe impacts on your health. Fitness fanatics will also know that elevated blood sugar levels are one of the major causes of inflammation, fat gain, and heart disease.

Semaglutide Overview

⭐️ Top Benefits: Increases glycaemic control and decreases hunger
🧪 Form: Injectable liquid
⌛️ Max Time Used: 6 – 8 Weeks
💰 Average Cost: $119.99
❤️‍🩹 Side Effects: Allergic reaction
☢️ Dangers: Allergic reaction
📚 Best Peptide Stack: HGH / IGF-1 / HGH-Frag
Men/Women: Men and women
➡️ Go to the Full review

  • Increases insulin control
  • Decreases hunger
  • Pain at the injection site
  • Allergic reaction
ADO 9604 Summary

AOD 9604

Losing excessive body weight and getting rid of obesity has just become much easier with the introduction of AOD9604 in the market.

AOD9604 is a synthetic fragment of the human growth hormone (HGH) C-terminus (176-191). This hexadecapeptide has shown great effects on fat metabolism by upregulating lipolysis and inhibiting lipogenesis.

AOD9604 targets fat-rich areas and promotes fat breakdown without disturbing the overall metabolic profile.

AOD9604 was well advocated as an anti-obesity medication in the past as it cuts down fat deposition. Perhaps this was confirmed in one of the clinical trials taking place in Australia, where nearly 300 obese individuals experienced weight loss.

Besides, AOD9604 doesn’t affect IGF-1 and insulin levels, thus ensuring minimal risk of developing glucose intolerance and diabetes mellitus. With AOD9604, you don’t have to worry about hypercholesterolemia as well!

The good news is that AOD9604 is an FDA-approved drug as an anti-obesity drug, so you don’t have to worry about adverse effects at all. All you can expect is mild headaches, indigestion, nausea, swelling, etc.

AOD9604 can really be your go-to therapy for weight loss but make sure to use it at the right dosages, or else a disturbed metabolic profile awaits you!


💉 Forms : Powders, Spray
🕑 Cycle Length:
20 Days
💊 Dosage: 300 mcg/day
Benefits: Weightless, Prevents Hypercholesterolemia
💸 Cost : $79.99
⚠️ Side Effects: Headache, Indigestion
Stacks: AOD 9604/Semaglutide

  • Marked fat loss
  • Can help prevent cardiovascular and metabolic disorders away
  • Pain, redness, and flushing of the face can be experienced after the injection
Ipamorelin Summary


Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH-releasing potency and efficacy in vitro and in vivo.

Being a synthetic derivative of growth hormone-releasing peptide 1 (GHRP-1), it follows the same course of action and shows similar benefits in the body.

The research suggests that it is more effective in terms of functioning than other similar peptides like GHRP-2 and GHRP-6.

The primary takeaway from ipamorelin intake is the increase in blood growth hormone (GH) levels. The other changes seen in the physique of the body are just results of elevated blood growth hormone (GH) levels.

Ipamorelin Overview

⭐️ Top Benefits: Increases natural HGH production
🧪 Form: Injectable liquid
⌛️ Max Time Used: Up to 3 months
💰 Average Cost: $52.99
❤️‍🩹 Side Effects: Insulin resistance
☢️ Dangers: Not really
📚 Best Peptide Stack: HGH / IGF-1 / GHRP / CJC-1295
Men/Women: Men and women
➡️ Go to the Full review

  • Muscle gain
  • Fat Loss
  • Increased bone density
  • Injection site pain
  • Insulin resistance
Tesamorelin Summary


As Tesamorelin mimics the action of a naturally occurring endogenous hormone, it also acts on specific target sites. Hence, the mechanism of action followed by tesamorelin is very specific.

Tesamorelin binds to the growth hormone-releasing hormone receptors (GHRHr) located in the anterior pituitary gland. This binding stimulates the somatotrophic cells in the pituitary gland to synthesize and secrete growth hormone (GH).

Growth hormone (GH) acts primarily on adipocytes (fat cells), hepatocytes (liver cells), myocytes (muscle cells), and osteoblasts (bone cells).

To ensure the tesamorelin-induced release of growth hormone (GH) is within set limits, a negative feedback mechanism is initiated, so that serum growth hormone (GH) levels don’t overshoot.

As tesamorelin triggers the release of growth hormone (GH) naturally, it maintains homeostatic coordination between Hypothalamus and pituitary gland.

Tesamorelin Overview

⭐️ Top Benefits: Increases natural HGH production
🧪 Form: Injectable liquid
⌛️ Max Time Used: 14 weeks
💰 Average Cost: $91.99
❤️‍🩹 Side Effects: Insulin resistance
☢️ Dangers: Not really
📚 Best Peptide Stack: GHRP / HGH / IGF-1
Men/Women: Men and women
➡️ Go to the Full review

  • Muscle gain
  • Fat Loss
  • Increased bone density
  • Injection site pain
  • Insulin resistance
Melanotan II Summary

Melanotan II

Melanotan II acts as a non-selective agonist of Melanocortin receptors. It also binds with MC-1R to initiate the process of melanogenesis – darkening of the skin.

Melanotan II works very effectively in making your skin tanned according to your requirements if taken in optimal dosage. Melanotan II offers a lot of supplemental benefits besides just tanning your skin. Because it binds to MC-4R, it plays a substantial role in the homeostatic mechanism.

It regulates your body’s energy requirements and regulates your appetite/hunger cycles. It does this by reducing fat storage, essentially mimicking the role of the leptin hormone. This can be linked to Melanotan II’s potential treatment for diabetes, but so far it is just a hypothesis.

Research suggests that Melanotan II strengthens libido in individuals and enhances sexual performance, primarily affecting males as it improves male erectile functionality. This was confirmed by one of the clinical trials involving 10 men diagnosed with erectile dysfunction. Out of 10 men, 8 men had a reversal of erectile dysfunction.

Melanotan II Overview

⭐️ Top Benefits: Skin tanning, Energy homeostasis, Treats ED
🧪 Form: Injectable peptides, Nasal sprays
💉 Typical Dosage: 0.1 mg to 1 mg
⌛️ Typical cycle duration: Variable
💰 Average Cost: $41
✅ Availability: Easily available
❤️‍🩹 Side Effects and Dangers: Spontaneous erections, systemic toxicity
📚 Best Peptide Stack: Melanotan 1 / Melanotan 2
➡️ Go to the Full review

  • Darkening of skin
  • Fat Loss
  • Improved libido
  • Kidney damage
  • Diarrhea
  • Priapism

What are Peptides?

Peptides are small chains of amino acids and therefore the building blocks of proteins  (4). Due to their concise and short structures, they’re rapidly absorbed in the bloodstream, leading to quick effects. 

Peptides are an integral part when it comes to maintaining our metabolic pathways. The majority of the peptides are used for increasing muscle bulk and gaining endurance. 

However, many emerging peptides have additional benefits as well. These include rapid weight loss,  strong immunity, wound healing, and many more! 

How Do Peptides for Female Fat Loss Work?

Each of the following peptides is distinct from the others in various ways. However, they all share one common feature, i.e., rapid fat loss in females. 

The majority of peptides cause the anterior pituitary gland to secrete more human growth hormone. Growth hormone inhibits lipoprotein lipase, which results in lipolysis as one of its notable effects (5). As a result, excess and unwanted triglycerides/cholesterol levels are reduced.

Moreover, several peptides, such as semaglutide and Tirzepatide, function as GLP-1 analogues. With this MOA, these peptides lower blood glucose levels and decrease appetite. As a result, there is a lower chance of obesity and T2DM.

Nevertheless, 5-Amino-1 MQ operates with a completely different approach. The peptide increases metabolism by inhibiting the nicotinamide N-methyltransferase (NNMT) enzyme.

As a result, these peptides speed up the burning of subcutaneous and abdominal fat reserves. They also minimize the risk of visceral obesity, which can lead to fatal consequences.

Benefits of peptides

Peptides are quite dynamic supplements that aid in diverse processes. With effective peptide therapy, you can reduce weight gain alongside increasing muscle mass. Besides this, studies also confirm the use of peptides in improving wrinkles and slowing the aging process (6). 

Peptides are often used among athletes for rapid wound healing and joint recovery besides muscle growth and muscle building. Most peptides also contain antioxidant properties, leading to reduced oxidative stress. Peptides with anti-inflammatory attributes can help you strengthen your immune system as well. 

Research also suggests that proper use of peptide therapy can also decrease age-related bone loss, especially in females (7). 

Are peptides Legal?

Peptides are usually prohibited for human consumption by the FDA. Nonetheless, these are available and legalized for research purposes only for clinical trials and studies. 

Peptides like Semaglutide and Tirzepatide are however FDA approved under a professional’s prescription. 

Who Should Use Fat Loss Peptides?

Fat Loss peptides can be used by anyone looking for ways to promote excess weight loss and have a better-looking physique. Nonetheless, most of the time it is indicated for reducing morbid obesity and rapid fat loss in certain diseases like T2DM (8). 

How to Use Peptides?

Other forms of peptides such as oral/tablet/capsule form, creams, nasal sprays, transdermal patches, and liquid are quite easier to use. However, it’s the injectable forms that give a hard time. But, don’t you worry! 

For injectable peptides, you’ll have to reconstitute the peptide that’s available in powder form. To do so, add drops of bacteriostatic water in the peptide vial carefully according to the recommended dosage guidelines.. After this, keep the peptides in favorable conditions and away from children. 

For administration, one of the three commonly used routes can opt. These include intravenous, intramuscular, and subcutaneous methods. 


What do peptides do to your body?

Peptides cause numerous beneficial effects. They can help reduce inflammation, gain muscle mass, increase endurance, and treat certain diseases. 

What peptides are used for fat loss in females? 

Peptides like CJC 1295, Tirzepatide, Semaglutide, Sermorelin, and 5-Amino-1MQ are five of the best peptides indicated for fat loss. 

Do peptides have side effects? 

The majority of the peptides are safe for human consumption. However, mild effects such as headaches, dizziness, or nausea may be reported.  

Are peptides safe? 

Yes! Most peptides are entirely safe for human consumption without causing adverse reactions.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it. We’ll also be answering questions on our Instagram!

1- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007. PMID: 18031173.
2- Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
3- Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4. PMID: 35658024.
4- Forbes J, Krishnamurthy K. Biochemistry, Peptide. 2022 Aug 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32965931.
5- Vélez EJ, Perelló-Amorós M, Lutfi E, Azizi S, Capilla E, Navarro I, Pérez-Sánchez J, Calduch-Giner JA, Blasco J, Fernández-Borràs J, Gutiérrez J. A long-term growth hormone treatment stimulates growth and lipolysis in gilthead sea bream juveniles. Comp Biochem Physiol A Mol Integr Physiol. 2019 Jun;232:67-78. doi: 10.1016/j.cbpa.2019.03.012. Epub 2019 Mar 15. PMID: 30885833.
6- Jeong S, Yoon S, Kim S, Jung J, Kor M, Shin K, Lim C, Han HS, Lee H, Park KY, Kim J, Chung HJ, Kim HJ. Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression. Int J Mol Sci. 2019 Dec 20;21(1):73. doi: 10.3390/ijms21010073. PMID: 31861912; PMCID: PMC6981886.
7- https://www.medicalnewstoday.com/articles/326701
8- Baruah MP, Kalra S. The novel use of GLP-1 analogue and insulin combination in type 2 diabetes mellitus. Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):129-35. doi: 10.2174/187221412800604563. PMID: 22435393.


Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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