ARA-290 Peptide Guide – Effects, Dosage, Side Effects

Chronic conditions like Diabetes Mellitus, Sarcoidosis, or Systemic lupus erythematosus can affect your life in so many negative ways, especially if coupled with neuropathic pain. If you are looking to get rid of the neuropathic pain associated with these medical conditions, ARA-290 is what you NEED!

People diagnosed with chronic conditions like diabetes often suffer from neuropathic pain due to diabetic neuropathy at some point in their lives. This is because of the impaired functioning of the nervous system, and this is the reason why most people experience burning and tingling sensations in their hands and feet (peripheral neuropathy).

It is important to know that while lifestyle changes, such as exercise, help in curbing the pain, it is definitely not a solid treatment and may also not work for everyone.

In such situations, peptides like ARA-290 help in treating neuropathic pain and allow people to put their lives back on track!

Besides this, ARA-290 has to offer various other benefits as well that we will go through in this review. Read more to find out if ARA-290 is the peptide you were always been looking for!

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways:

  1. ARA-290 is a nonhematopoietic erythropoietin analog that primarily works to improve the symptoms of neuropathic pain.
  2. ARA-290 offers chronic pain relief from diabetic neuropathy, sarcoidosis-induced neuropathic pain, as well as from any tissue injury.
  3. Due to the anti-inflammatory pathways triggered by ARA-290, it also ensures quicker wound repair and healing.
  4. BioTech peptides is one of the best places to make your ARA-290 purchase

What is ARA-290?

ARA-290 is a peptide consisting of 11 amino acids. It is derived from the tertiary structure of erythropoietin, which is a naturally occurring peptide in our body. The main function of erythropoietin is to stimulate the production of red blood cells in the bone marrow alongside exerting other effects in the body. (1

Since ARA-290 is a nonhematopoietic erythropoietin analogue, it does not have the ability to stimulate red blood cell production. It instead modulates all other mechanisms, which include neuroprotection, altering blood pressure, and promoting cell growth.   

How does ARA-290 work?

To understand the mechanism of action of ARA-290, we must bear in mind that since it is derived from erythropoietin, its mechanism of action will be pretty similar to it. 

The most widely-studied function of ARA-290 is its ability to decrease the intensity of neuropathic pain. It does this by acting on the innate repair receptor (IRR) and decreasing inflammation via the downregulation of inflammatory pathways. 

ARA-290 also inhibits the activity of the TRPV1 channel, which is primarily responsible for perceiving heat and burning pain, which is most often reported in neuropathic diseases. (2

In other cases of small fiber neuropathy, small peripheral nerve fibers in the skin may get severed, which causes pain, burning, and tingling sensation. ARA-290 is able to reduce this pain by increasing the number of small nerve fibers. (3)

One major effect of ARA-290 is directly linked to its anti-inflammatory property. It inhibits macrophage activation and has the ability to bind to protective tissue receptors (TPR) on cells. This consequently suppresses inflammatory cytokines like IL-2, IL-6, and tumor necrosis factor. 

Therefore, every cell that expresses TPR will be directly affected by the action of ARA-290. These include macrophages, dendritic cells, mast cells, and lymphocytes which are all part of the innate immune response. 

A decrease in the number of cells in the immune system will then halt other destructive mechanisms that usually accompany an inflammatory reaction and simultaneously promote skin and tissue healing.

Benefits of ARA-290

Now that we know that ARA-290 can decrease neuropathic pain by inhibiting TRPV1 receptors, this makes it an extremely beneficial peptide for patients suffering from pain due to peripheral neuropathy associated with type 2 diabetes, multiple sclerosis, and sarcoidosis. (4

ARA-290 Peptide Guide - Effects, Dosage, Side Effects
Fig 1. ARA-290 induced improvement in neuropathic pain in patients with T2DM

A study showed that intravenous administration of ARA-290 to patients with sarcoidosis-induced neuropathic pain showed a 50% improvement in pain without any safety concerns. This proves that ARA-290 can significantly improve the quality of life. (5

ARA-290 Peptide Guide - Effects, Dosage, Side Effects
Fig 2. 3-week treatment results of ARA-290 in sarcoidosis-induced neuropathic pain

In cases of diabetic retinopathy, ARA-290 is able to exert its neuroprotective effects to protect the retina from neuroglial and vascular degeneration. It increases corneal nerve fiber density, which may prevent vision loss in patients with diabetes mellitus. (6

Its anti-inflammatory properties make it a potent peptide for curbing pain that people with autoimmune diseases may experience. One such example is rheumatoid arthritis, in which joint pain is primarily due to the presence of immune cells. 

Other than acquired and autoimmune diseases, ARA-290 can also modulate chronic pain that may follow procedures such as chemotherapy and amputation. (7

One very unique application of the anti-inflammatory effect of this peptide has been observed in mice that had undergone a transplant of the islet cells of the pancreas. This transplant is done to treat patients with diabetes mellitus. 

Normally, the transplanted islet cells are unable to survive due to inflammatory reactions after the surgery. In this situation, ARA-290 inhibited the release of inflammatory cytokines from macrophages and thereby ensured the longevity of the transplanted cells. (8

Due to its wound-healing properties, ARA-209 has proven to be beneficial in treating burn injuries that reduce the necessity for skin grafting. (9

Some studies have also revealed that ARA-290 can prevent ischemic myocardial damage in rats who may have different heart problems. (10)

Is ARA-290 Legal?

Clinical trials done on animals to study the effect of ARA-290 had yielded promising results. 

On the basis of this research, FDA granted ARA-290 the designation of an Orphan drug for the treatment of patients with sarcoid neuropathy. Further studies exploring its efficacy are underway which may allow for its further use. 

Who Should Use ARA-290?

ARA-290 is specifically proven to be effective in dealing with neuropathic pain and thus can be used as a pain reliever in any chronic or autoimmune disease. This may include sarcoidosis, multiple sclerosis, diabetes, and systemic lupus erythematosus.

It not only improves nerve pain but also protects the body from further damage, such as in the case of diabetic retinopathy.

ARA-290 has tissue-protective functions which can stimulate wound repair and thus can be used by people suffering from bruises, cuts, and burns.

For patients who have undergone islets cell transplant, ARA-290 can help maintain the viability of the tissue by inhibiting pro-inflammatory cytokines.

Forms of ARA-290

ARA-290 is only available in two forms as of yet, amongst which the injectable form is used for the treatment of most conditions. Within the injectable form, pre-mixed pens have also gained popularity due to their accurate and convenient application.

The other form is the intranasal spray which is easier to administer and also has minimal side effects. 

How to Use ARA-290? 

ARA-290 injections can be safely administered at home. 

As a precautionary measure, it must be made sure that the site where this peptide will be injected is clean. 

The intranasal spray can be inhaled at convenience without any major risks. 

ARA-290 Dosage

It is generally recommended to seek a prescription from a medical healthcare professional before starting the use of ARA-290. Every condition may require a different dose, and it may take some time to achieve the desired result.

A standard and safe dosage, however, is an injection of 0.7 ml that comes in a 4 ml vial of 6 mg/ml solution. 

The intranasal spray is mostly available as a 15 ml solution which may contain 2 mg of ARA-290 peptide. 

ARA-290 Cycling

0.7 ml from a 4 mg/ml solution of ARA-290 solution must be administered three times a week for 4-5 weeks. The vial can be injected subcutaneously

Nasal sprays have no specific guidelines, thus, a healthcare practitioner must be consulted before using it.

 ARA-290 Stacks

ARA-290 is often not stacked with other peptides. Its neuroprotective effects alone have proven to be sufficient in alleviating pain. 

If ever the need arises, it can be used alongside other recreational supplements to receive an array of benefits after consulting a healthcare professional. 

ARA-290 User Reviews

Time to dig into some of the anecdotal evidence and see what people have to say about this magical pain-relieving peptide!

One of the users said,

“I’ve taken it it helps with pain but it’s temporary. You have to keep doing it from time to time at least and it’s expensive.”

Another user validated that,

“ARA is freaking awesome. Works better than IVIG ever did for me. Within 2hrs i feel better, but, you need to keep using it.”

Another ARA-290 user said,

“I am almost done with a month of ara 290. I’m not part of a trial but I am using it. It’s not cheap. I have seen really great results. My neuropathy was very bad and it has improved significantly. I have tried almost everything and this was the most helpful by far. Whether it lasts I’ll have to see.”

While the list of these Reddit opinions can go on and on, I think ARA-290 is definitely a solid peptide, and people have found it extremely helpful.

ARA-290 Side Effects 

Scientific data has depicted successful outcomes and overall safety of ARA-290 in human subjects. This is in contrast to erythropoietin, which is the parent molecule for this peptide and has some extreme side effects.

Serious side effects of ARA-290 have not been reported, but some common ones may include swelling, itching, or bruising at the site of injection. Plus, headache has also been widely reported.

Where can I buy ARA-290?

Now if you have made it this far in the review, I am pretty sure that you have made up your mind to buy ARA-290!

Speaking of facts, not many authentic vendors offer ARA-290 peptides, and the ones that do sell are extremely costly.

Nonetheless, one of the online stores that I completely vouch for is BioTech Peptides.

ARA-290 By BioTech Peptides

Biotech peptides offer almost all kinds of peptides available in the market. As far as ARA-290 is concerned, it is also available in one variant. 

Biotech peptides commonly offer 16mg of ARA-290, costing $85.00, which is a pretty reasonable price, unlike other vendors in the market. 

BioTech peptides are at the top, with 99% product purity. They also offer 5%-10% discounts for customer retention depending on your purchase. 

Surprisingly, they also have a same-day shipping facility with a 30-day money-back guarantee. 

  • 99% pure and authentic 
  • Same-day shipping policy 
  • Excellent customer reviews
  • Relatively expensive 

ARA-290 vs. Other Peptides

ARA-290 vs. Thymosin Alpha 1

ARA-290 is isolated from erythropoietin, and Thymosin Alpha 1 is isolated from the thymus, thus, both these peptides are found in the body naturally. Both of these have important anti-inflammatory functions in the body as well, but their mechanism differs.

ARA-290 binds tissue receptors on cells to inhibit proinflammatory cytokines, whereas Thymosin Alpha 1 interacts with toll-like receptors to modulate the immune system.

Is ARA-290 Legit?

Considering that ARA-290 has been granted the status of an orphan drug, it can be safely assumed that the benefits of this peptide are widely recognized, specifically in the treatment of neuropathic pain.

This significantly elevates the quality of life for people who might be suffering from chronic illnesses such as diabetic neuropathy and sarcoidosis. 

Furthermore, its multipotent effects, including its quicker wound-healing action, make it an important peptide for people looking forward to benefiting from its use!  

Even though any major side effects have not been reported, it is essential that you assess the benefits of ARA-290 and make an informed decision about using this peptide. 

People Also Search For

Can peptides help with nerve damage?

The peptides that are used to reduce neuropathy are specific to reduce the inflammation around the nerve as well as help the nerve repair quickly.

What is the half-life of the ARA-290 peptide?

It has a short plasma half-life of 2 minutes.

Is ARA 290 safe?

No adverse events have been associated with the administration of a single dose of 70 -2000 μg ARA290 among 36 individuals, with the exception of one individual (with an undisclosed significant prior history of fainting) who fainted shortly after the intravenous dose administration of 700 μg ARA290 and recovered.

What is small fiber neuropathy?

Small fiber neuropathy occurs when damage to the peripheral nerves predominantly or entirely affects the small myelinated (Aδ) fibers or unmyelinated C fibers. The specific fiber types involved in this process include both small somatic and autonomic fibers.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it. We’ll also be answering questions on our Instagram!

1)Brines, M., Patel, N. S., Villa, P., Brines, C., Mennini, T., De Paola, M., Erbayraktar, Z., Erbayraktar, S., Sepodes, B., Thiemermann, C., Ghezzi, P., Yamin, M., Hand, C. C., Xie, Q. W., Coleman, T., & Cerami, A. (2008). Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America, 105(31), 10925–10930.
2)Brandt, M. R., Beyer, C. E., & Stahl, S. M. (2012). TRPV1 Antagonists and Chronic Pain: Beyond Thermal Perception. Pharmaceuticals (Basel, Switzerland), 5(2), 114–132.
3)Hoitsma, E., De Vries, J., & Drent, M. (2011). The small fiber neuropathy screening list: Construction and cross-validation in sarcoidosis. Respiratory medicine, 105(1), 95–100.
4)van Velzen, M., Heij, L., Niesters, M., Cerami, A., Dunne, A., Dahan, A., & Brines, M. (2014). ARA 290 for treatment of small fiber neuropathy in sarcoidosis. Expert opinion on investigational drugs, 23(4), 541–550.
5) Niesters, M., Swartjes, M., Heij, L. R., Brines, M., Cerami, A., Dunne, A., Hoitsma, E., & Dahan, A. (2013). The erythropoietin analog ARA 290 for treatment of sarcoidosis-induced chronic neuropathic pain. Expert Opinion on Orphan Drugs, 1(1), 77–87.
6)McVicar, C. M., Hamilton, R., Colhoun, L. M., Gardiner, T. A., Brines, M., Cerami, A., & Stitt, A. W. (2011). Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy. Diabetes, 60(11), 2995–3005.
7)Joshi, D., Abraham, D., Shiwen, X., Baker, D., & Tsui, J. (2014). Potential role of erythropoietin receptors and ligands in attenuating apoptosis and inflammation in critical limb ischemia. Journal of vascular surgery, 60(1), 191–201.e2012.
8)Watanabe, M., Lundgren, T., Saito, Y., Cerami, A., Brines, M., Östenson, C. G., & Kumagai-Braesch, M. (2016). A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets. Transplantation, 100(3), 554–562.
9)Bohr, S., Patel, S. J., Shen, K., Vitalo, A. G., Brines, M., Cerami, A., Berthiaume, F., & Yarmush, M. L. (2013). Alternative erythropoietin-mediated signaling prevents secondary microvascular thrombosis and inflammation within cutaneous burns. Proceedings of the National Academy of Sciences of the United States of America, 110(9), 3513–3518. https://doi.org/10.1073/pnas.1214099110
10) Ahmet, I., Tae, H. J., Brines, M., Cerami, A., Lakatta, E. G., & Talan, M. I. (2013). Chronic administration of small nonerythropoietic peptide sequence of erythropoietin effectively ameliorates the progression of postmyocardial infarction-dilated cardiomyopathy. The Journal of pharmacology and experimental therapeutics, 345(3), 446–456. https://doi.org/10.1124/jpet.113.202945

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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Chemical Structure

Mechanism of Action

ARA-290 is a peptide which is derived from the tertiary structure of erythropoietin and thus is also known as nonhematopoietic erythropoietin analogue. It acts on the innate repair receptors and inhibits the activity TRPV1 channel which are responsible for perceiving pain and thereby reduces neuropathic pain. ARA-290 is specifically useful in the cases of small fiber neuropathy where it increases the number of small nerve fibers and helps in relieving burning and tingling sensations on the extremities. This peptide is also able to suppress inflammatory cytokines by binding to tissue protective receptors which helps in quicker wound healing.

Class of Compound

Peptide

Street Names

ARA-290, Cibinetide, Nonhematopoietic erythropoietin analogue

Effects

Treats neuropathic pain ,Wound-healing , Anti-inflammatory

Side Effects and Dangers

Headache , Pain at injection site , Redness at injection site

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