Phenibut Review: Uses, Benefits, Side Effects

Phenibut, also chemically known as beta-phenyl-gamma-aminobutyric acid HCl (1), is a synthetic derivative of Gamma-Aminobutyric acid or GABA, one of the major inhibitory neurotransmitters found in our central nervous system. 

With the dynamics of the world changing dramatically, anxiety and depression have become prevalent in the recent past.

Perhaps insomnia, fear, and asthenia-like signs and symptoms augment these neurological conditions and make it a really difficult phase for the patients.

As more people are falling into the trap of different neurological disorders, scientists and researchers have been trying hard to develop the most effective treatment for anxiety and depression. 

While the use of nootropics has significantly increased in the recent past, the integration of the anxiolytic aspect into cognition is definitely a breakthrough.

One such nootropic cum anxiolytic supplement that we are going to talk about in this article is Phenibut, a 1960’s Russian-made product. 

With its potent effects on relaxing the mind as well as improving memory and neurological health by working at the cellular level, the customer base of Phenibut has only grown stronger since its development. 

Read through the end to know everything about Phenibut Review such as how it exactly works, the potential benefits, the side effects, the dosage, and stacking guidelines, and importantly the research and anecdotal evidence of its effects.

Best Phenibut Sources

  1.  Phenibut by Nootropics Depot 
  2.  Phenibut by Pure Rawz 
  3.  Phenibut by Liftmode 

Phenibut by Nootropics Depot

One of the best places to buy Phenibut from is Nootropics Depot. You can either buy capsules or powder form depending on your preference. 

Both forms of Phenibut are available in multiple power variants. 
You can add Phenibut HCl 250 mg capsules into your bucket or you can buy Phenibut HCl Powder which is available as 25g, 125g, or 250g. 

With same-day shipping and free standard worldwide mail shipping on orders above $200, Nootropics depot offers a lot in a very considerable price range of $16.99 to $32.99. 

Considering so much of positive and satisfied reviews from the customers, I would definitely vouch for Nootropics depot any time of the day. 

Read full Nootropics Depot Review

Pros

  • Powder and Capsules are both available 
  • Multiple power variants are available 
  • Satisfied customers 

Cons

  • Can’t be delivered to Australia and Ireland 
  • May be out of stock sometimes

Phenibut by Pure Rawz

Pure Rawz offers capsules, powder and liquid form of Phenibut, thus making sure that all the possible demands of customers are ticked. 

Pure Rawz also offers multiple variants of the nootropic. This makes sure that the dosage requirements of the customers are fully met.

With lab-tested quality product, secure payment method, free shipping on orders above $100, and 100% satisfaction, Pure Rawz offers top-quality nootropic product in your budget. 

Depending on the variant, type and quantity that you buy, the price range would typically fall between $21.48 and $73.48. 

Read full Pure Rawz Review

Pros

  • Multiple forms available 
  • Premium customer service by the brand 

Cons

  • Only available for research purposes 
  • May be relatively expensive
Phenibut Review: Uses, Benefits, Side Effects

Phenibut by LiftMode

Liftmode, a popular growing nootropic brand offers a wide variety of Phenibut products, including Phenibut HCl (fine crystals), Phenibut HCl (large crystals), Powder, and capsules, as well as Phenibut Free Amino Acid (FAA).

Each of the products are available in multiple variants aiming to target a larger target market. 

Each of Liftmode’s products are HPLC Lab tested, vegan, Non-GMO, gluten-free as well as free of any additives. With scientifically-backed evidence, Phenibut by Liftmode is one heck of a choice! 

The prices will vary depending on your purchase but you would be charged anywhere between $8.68 to $178.68. 

With the majority of customers crediting Liftmode’s Phenibut, I will definitely recommend it to enjoy an anti-anxiety life.

Pros

  • HPLC lab tested 
  • A lot of options available in terms of form and variety 

Cons

  • Prices may be high 

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What is Phenibut? 

Phenibut, also chemically known as beta-phenyl-gamma-aminobutyric acid HCl (1), is a synthetic derivative of Gamma-Aminobutyric acid or GABA, one of the major inhibitory neurotransmitters found in our central nervous system. 

If we try to understand the structure of Phenibut for a second, an important thing to note is that it comprises a phenyl ring on the β-position (2), thus making it easier for the drug to cross the blood-brain barrier and have its inhibitory effects. 

This neuropsychotropic drug was originally developed in Russia back in 1960 and is a part of Russian clinical practice since then. 

It is popularly sold under the brand name of Anvifen, Fenibut, and Noofen. 

This psychoactive medication is generally prescribed to manage and treat conditions like anxiety, depression, insomnia, stress, stuttering, vestibular disorders, etc. 

Mechanism of Action

A clue as to how this compound works can be interpreted from its chemical name, called beta-phenyl-gamma-aminobutyric acid HCl. 

As mentioned earlier, Phenibut is a phenylated derivative of GABA. In supplement form, GABA is unable to successfully penetrate the blood-brain barrier (3). The unique chemical composition of Phenibut allows it to cross this protective blood-brain barrier and exhibit inhibitory effects or rather relaxing and calming effects in the central nervous system.  

The pharmacological studies of Phenibut suggest that it works just like Baclofen. Once it is inside the brain, it mimics the action of GABA, acting mainly as a potent agonist of GABA(B) receptors (4). However, it can mildly bind to GABA(A) receptors as well. 

Research suggests that it also binds to dopamine receptors and triggers its release.

As an anxiolytic nootropic, it is also known to bind to beta-phenethylamine (PEA), which is a central nervous system stimulant.  

Only 0.1% of the Phenibut dose crosses the blood-brain barrier, and the pharmacokinetics suggest that the half-life of Phenibut is 5.3 hours. 

Benefits of Phenibut 

While the predominant effects of Phenibut are on the central nervous system because of its anxiolytic and cognitive effects, let’s try to dig into more details of the potential benefits that it offers. 

Manages the Anxiety

Not to forget, Phenibut was developed to manage and treat symptoms related to anxiety and depression. The user reviews on the benefits of Phenibut as an anxiety-fighting compound are seemingly endless, and there is a handful of scientific and clinical evidence to back it up (5).

Cognitive Benefits: Learning, Memory, and Neuroprotection

Multiple animal studies have found nootropic benefits of Phenibut (5). In one study on rabbits, supplementation in early life was found to accelerate defensive reflex and conditioned inhibition development – this suggests that this drug may help to improve memory storage and learning.

Other animal studies found this nootropic to exhibit anti-amnesic effects, possesses neuroprotective properties and reduced cognitive injury from stroke.

While the cognitive effects of Phenibut are not that pronounced as compared to other nootropics, the stack of Phenibut with other nootropics seems to be a miracle. 

Helps Sleep Better

Because of its calming and slightly sedative effects, many who use this drug for anxiety report benefits with sleep and insomnia. This effect is likely to be more pronounced in those suffering from anxiety-induced insomnia.

Cardiovascular Protection

Animal studies have found this drug to protect the heart during periods of stress, improve heart rhythm, and protect from cardiac damage caused by acute alcoholic intoxication (6).

Strengthens the Immune System

There is a positive association between chronic stress, anxiety, and a weak immune system. 

Because of the anxiolytic effects, now it shouldn’t be much of a surprise that Phenibut, likely through its ability to calm excitatory responses in the body, has been found to restore the immune system of mice (7).

Speech and Hearing Effects

There is also a shred of weak evidence that suggests Phenibut can improve stuttering and other vestibular disorders. This means Phenibut can work on the brainstem level and improve pathways that manage speech and hearing. 

Is Phenibut Legal?

Because it is a Russian-made drug, it is legal and common to use Phenibut. It is also commonly used in Eastern Europe as a recreational supplement cum nootropic.

Phenibut is also legal in the US and Canada and is not classified as a controlled substance. Thus, you can purchase it without a prescription from any local vendor. 

In the UK, it is unlicensed and unregulated, making it legal to possess but not legal to sell.

In Australia, it is illegal to sell and buy Phenibut at all. 

Dosage Guide: How to Take Phenibut Safely?

While there are no recommended dosage guidelines, because it is commonly consumed, human experiences suggest that anywhere from 250 to 500 mg/day of Phenibut is generally found safe. 

As with most other nootropics, it is advised to start at a low dose and work your way up, until you find the right and optimal dosage for you. 

Things to Consider Before You Take Phenibut

Even though Phenibut is used successfully in nootropic stacks, you need to be careful of dangerous combinations. Combining it with certain anxiolytics or alcohol is not recommended. 

There are other risk factors including the risk of tolerance and withdrawal symptoms as well (8,9). Because Phenibut dependency develops quickly, it is quite possible to develop withdrawal symptoms such as anxiety, drowsiness, nausea, hypotension, restlessness, reduced appetite, and irregular heart rhythm.

Side Effects of Phenibut 

Understanding not just the benefits, but also the risks and potential side effects of any nootropic supplement that you add to your stack is of critical importance.

Intermittent and low doses of Phenibut are generally well tolerated. When taken in higher doses, or daily for extended periods of time, Phenibut is know to come with a side effect profile that users need to be aware of.

Side effects reported by user reviews at lower doses include:

  • Headache
  • Loss of appetite
  • Dizziness
  • Nausea
  • Anxiety
  • Mental and physical fatigue
  • Sleepiness
  • Mild stimulation

When taking higher doses, many users report sedative effects, similar to those of powerful anxiolytic prescription drugs like Xanax. In addition to the side effects listed above, at high doses users have reported:

  • Heart palpitations
  • Respiratory depression
  • Motor Impairment and trouble with balance

Last but not least, an overdose of Phenibut can lead to lowered blood pressure, liver or kidney problems, and seizures, among other serious adverse reactions. An overdose is far more dangerous when combined with other depressants, including alcohol, opioids, narcotic drugs, or sedatives.

Phenibut User Reviews 

It is important to know about people’s experience with any particular recreational drug or supplement, especially when human clinical trials have not yet been performed. 

Online user reviews are the best way to find answers to these questions. As you will see from the below reviews, experiences with this nootropic vary widely from one person to another. You can use this information to help guide you through how best to take Phenibut.

One of the Reddit user blytboy gave a comprehensive review saying, 

“A few months ago I took phenibut regularly (i.e. at most 1000 mg every 3 or 4 days). I was responsible with it. It felt good. No man, it felt freaking great. All the positive effects you read about, getting rid of anxiety, boosting sociability, energy, mood etc… They’re all real.”

u/simply_fab5 said, 

“Took it for the first time today, and it was honestly one of the happiest days I’ve had in months maybe even a year. It was really small things that made it so great. I was able to talk to people today like I never have. Small talk was enjoyable, and I didn’t feel anxious walking around people. I smiled more and was able to enjoy just walking outside. I was productive and got work done. I love this.”

Another Reddit user said, 

“Before all this Xanax was my favourite drug because it relieved me of anxiety and paranoia but in a very ‘I DONT GIVE A FUDGE’ attitude.

Phenibut fights my anxiety in a much better way. It’s more like I have trust and love everyone and want to talk to random people on the street. It is awesome and I love it! 

Perhaps an honest insight was shared by dmann8383, 

“I would use pheibut like any benzodiazepine. I think I may just be rehashing what you said but it (phenibut) acts as a masking agent and not a cure for whatever is ailing you. It does not get to any root cause. I do think the medicine has great potential as an acute remedy for panic attacks and anxiety in general, but moderation and personal responsibility is key to successful use.”

Best Phenibut Stacks

Phenibut is one of the most commonly stacked nootropics – this is mostly because it offers strong anxiolytic effects with a mild degree of enhanced cognition. By stacking this drug with other potent nootropics, you can tailor your anti-anxiety stack to include additional neurological and other possible benefits.

Phenibut and Piracetam

Piracetam and Phenibut are often stacked to provide a well-rounded nootropic experience. Piracetam offers improved brain health, memory, enhanced learning and boosts concentration while Phenibut works to reduce anxiety and stress.

Noopept and Phenibut

Just as Phenibut is one of the most potent anxiolytics, Noopept is one of the most powerful nootropics when it comes to improving memory, learning, and brain health. Combining these two can offer a good experience to the potential user who is looking to notice very dramatic changes in cognition and mood.

Phenibut and Kratom

If you suffer from debilitating social anxiety, this combination may help you find relief. Kratom, a plant extract with Phenibut can have strong and powerful anxiolytic effects. This stack is best for those suffering from anxiety disorders. 

One thing to note is that it is not your typical mood-boosting nootropic stack.

Aniracetam and Phenibut

Users report a synergy between these two anxiolytic nootropic compounds. Although the mechanism of action of both nootropics is different, they work on reducing stress and anxiety through different paths. 

As Aniracetam does not lead to withdrawal, it can be helpful to stack with Phenibut, which you should cycle regularly.

Sulbutiamine and Phenibut

Sulbutiamine is a synthetic derivative of Thiamine and offers a subtle boost in energy, and helps mitigate weakness and fatigue. It stacks well with Phenibut for the goal of boosting motivation and energy while simultaneously promoting a calm and relaxed mood.

Phenibut and L-Theanine

L-Theanine is a compound found in green tea that is touted for its health benefits. Both L-Theanine and Phenibut are known for their anxiolytic properties, thus they can work synergistically to induce calmness, relaxation, and improved concentration as well as focus.

Phenibut and Choline

Phenibut and choline are most frequently stacked together to promote athletic and fitness performance. Both of them together can have a combined effect on reducing stress and supporting Human growth hormone (HGH) levels.

Top Trusted Vendors and Suppliers: Where To Purchase Phenibut Online? 

Buying Phenibut from local pharmacies or local stores will depend on where you live. It is very easy to purchase Phenibut in USA and Canada because of widespread availability. However, you may not be able to find Phenibut in local stores in countries such as UK and Australia. 

It is important to only purchase Phenibut from a trustworthy online source – you may be able to find it easily, but that does not mean that it is the quality that you’re looking for.

Many of the trustworthy nootropics retailers do not carry Phenibut, but luckily there are still good options out there for those who know where to look.

Perhaps here I list top online vendors to buy Phenibut from. I would highly recommend buying from these stores based on the authenticity of the product, reviews, the brand image, and the pricing.

Phenibut vs Other Compounds

Phenibut vs Xanax

Alprazolam, sold under the brand name Xanax, belongs to triazolobenzodiazepine class, is a commonly used medication to alleviate anxiety and pain.

Xanax is a FDA-approved drug, and it acts on brain and nerves and provides a short term relief in the body. Perhaps it works by enhancing the effects of GABA whereas Phenibut mimics the action of GABA. 

However, using Xanax can also cause more severe side effects compared to Phenibut and needs to be carefully taken. 


Phenibut Vs Kratom

Kratom is a plant-based extract having opioid properties and some stimulant-like effects in the body. 

The two active compounds found in Kratom are mytragynine and 7-hydroxymytragynine. It is most commonly used to relieve pain, depression and opiod addiction. 

While Kratom can certainly alleviate your symptoms related to depression and anxiety, it comes at a cost. Severe side effects have been reported as compared to Phenibut such as cardiovascular issues, renal and hepatic problems. 

Phenibut vs GABA

GABA is a neurotransmitter produced endogenously in the human body. Synthetic GABA supplements do exist with purported benefits of promoting relaxation and a positive mood.

Phenibut acts mainly through mimicking GABA in the body and mind – the benefit of Phenibut over synthetic GABA supplements is that it is more capable of crossing over the blood-brain barrier, and thus its benefits on mood and cognition are greater than those of synthetic GABA.

Phenylethylamine HCl vs Phenibut

Phenylethylamine HCl, also known as PEA, is a compound that is produced endogenously in humans. It is known to help with mood, attention, energy, memory, and weight loss. It works through increasing the release of important neurotransmitters such as dopamine, norepinephrine, b-endorphin, and acetylcholine.

If you are looking for a nootropic mainly to fight anxiety and stress, Phenibut is the best option. 

PEA is better for overall improvement of mood outside of anxiety disorders, along with increasing learning ability and focus

Phenibut FAA vs HCl

There are two versions of this supplement to choose from: Phenibut Hydrochloride (Phenibut HCl) or Phenibut Free Amino Acid (Phenibut FAA). Phenibut HCl is the most widely used form of this nootropic and is best suited for taking in capsule or tablet form.

Phenibut FAA is best for sublingual use and is gaining popularity among neurohackers. Many report this form to be around three times as potent and bioavailable, so you may need a smaller dose of FAA in comparison to HCl. 

This form is more expensive than the HCl form.

Is Phenibut Legit? 

It is important to understand how Phenibut works in the body before you can really start using the nootropic. 

Based on the limited scientific information available as well as anecdotal evidence from the customers, Phenibut will definitely work for the majority of people on the neurological level. It will help alleviate your symptoms of anxiety, depression, insomnia and improve your overall health by working at cellular levels. 

However, one shouldn’t forget that data from human studies is pretty scarce and the adverse effects are for real if Phenibut is overdosed. Nonetheless, start using the nootropic cum anxiolytic drug and see yourself if it works for you. 

On a side note, if you really want to get rid of your anxiety, there are better multi-dimensional and diverse nootropic options available in the market, so maybe try out those!  

Is Phenibut water soluble?

Phenibut is water-soluble, so you do not need to take it with food. Taking it on an empty stomach is fine. If using the powder, mixing it with juice helps to mask the bitter taste. In order to avoid tolerance, you will either want to only take it when you need it or you can cycle, taking up to a few days on and a couple of days off.

How long does Phenibut take to kick in?

Most users will start to feel it kick in slightly around 30 minutes post consumption with the effects slowly building and lasting around 12 hours.

How long does Phenibut stay in your system?

With a half-life of roughly 5 hours and total elimination from your system not until 24 hours, it is important not to take too much of this compound in a 24-hour period.

Does Phenibut show up on a drug test?

Phenibut does not show up on a standard drug test.

https://pubmed.ncbi.nlm.nih.gov/11830761/
https://pubchem.ncbi.nlm.nih.gov/compound/4-Amino-3-phenylbutanoic-acid
https://pubmed.ncbi.nlm.nih.gov/26500584/
https://pubmed.ncbi.nlm.nih.gov/32340063/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952553/
https://pubmed.ncbi.nlm.nih.gov/16756131/
https://pubmed.ncbi.nlm.nih.gov/29949699/
https://pubmed.ncbi.nlm.nih.gov/23391959/
https://pubmed.ncbi.nlm.nih.gov/26693960/

Current Deal: Phenibut by Nootropics Depot

Phenibut by Nootropics Depot

Kartik Kumar Rathi

Kartik is a Doctor in training currently in his second year of medical school with the ultimate goal of becoming a successful cardiologist, he currently contributes to health blogs, research papers and also founded a social health startup to help educate others.

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Phenibut by Nootropics Depot

Phenibut by Nootropics Depot