Top Two Nootropics for Anxiety

Best Nootropics for Mood and Anxiety

Updated May 25, 2020

Top 3 Nootropics for Mood and Anxiety

Premium Choice
Qualia Mind
  • Trusted Brand
  • Caffeine or non-option
  • Sleep Benefits
Best Overall
best nootropics for mood and anxiety
Mind Lab Pro's Universal Nootropic
  • Universal Nootropic
  • Stimulant Free
  • 11 Major Ingredients
Best Value
Brain Booster by Vital Vitamins
  • Inexpensive
  • Improves Mood
  • Improves critical thinking
Top Two Nootropics for Anxiety

Top Two Nootropics for Anxiety

Genius Joy by The Genius Brand

best nootropics for mood Price: $57.99 for 100 capsules Serving Size and Directions: Take 1 capsule upon waking when first using this product. If comfortable, a second capsule may be consumed prior to consuming your second meal of the day. No more than 4 capsules should be taken per day, with 2 capsules taken per serving. Genius Joy comes packed with powerful ingredients that boost serotonin, promote energy and focus, and provide adequate relief from anxiety and stress. All ingredients are clinically backed and provide a holistic approach towards managing life’s everyday stressors. Genius Joy is able to provide the natural stress-relief that other products can’t through its ability to support dopamine production as well as maintain a proper balance between serotonin and dopamine. Ingredients: Vitamin B1 (Thiamine HCL), Vitamin B2 (Riboflavin-5-Phosphate), Vitamin B3 (Niacinamide), Vitamin B5 (D-Calcium Pantothenate), Vitamin B6 (Pyridoxal-5-Phosphate), Vitamin B12 (Methylcobalamin), Vitamin D3, S-Adenosylmethione Tosylate Disulfate (SAMe), N-Acetyl-L-Tyrosine ,Rhodiola Rosea [Root], Red Panax, Ginseng, 5-HTP, NeuroFactor Coffea Arabica, TheaKalm, L-Theanine.

  • Serotonin mood booster Provides relief from both anxiety and stress
  • Those who suffer from bipolar disorder or manic depression should limit their use of SAMe May cause gastrointestinal discomfort in a small percentage of people

Top 3 Nootropics for Mood

Mind Lab Pro’s Universal Nootropic

best nootropics for mood and anxietyPrice: $65 for 60 capsules Serving Size and Directions: Take 2 capsules per serving; Do not take more than 4 capsules within 24 hours. Mind Lab Pro® is a 100% natural, vegan and stimulant-free nootropic is best known for its ability to create a better mindset and mood within those who use it. Unlike other products, it doesn’t contain stimulants, such as adrafinil or those within the racetam family, making it the ideal product for those who are stimulant-sensitive or those who prefer a more relaxed state when trying to focus. It is considered to be a “universal nootropic” since it contains 11 major ingredients that support a full spectrum of cognitive functions. Major Ingredients: 250 mg Citicoline (Cognizin), 175 mg N-Acetyl-L-Tyrosine, 100 mg L-Theanine (Suntheanine), 100 mg Phosphatidylserine (Sharp PS Green), 150 mg Bacopa Monnieri (45% bacosides), 75 mg Maritime Pine Bark Extract, 500 mg Lion’s Mane Mushroom, 50 mg Rhodiola rosea (3% rosavins & 1% salidroside), 2.5 mg Vitamin B6, 100 mcg Vitamin B9, 7.5 mcg Vitamin B12.

  • Promotes motivation and a better mood Stimulant free
  • May lead to headaches or dizziness May cause jitteriness

Qualia Mind by Neurohacker Collective

Price: $139.00 for 154 capsules Serving Size and Directions: Take 7 capsules with water prior to eating; Limit use to 5 days a week. About Qualia Mind

This top-selling supplement from Neurohacker Collective is known for being a high-quality, extremely effective nootropic for improving cognition. Qualia supplements are designed through thousands of hours in research and development by top scientists, and are used by top athletes, professors and entrepreneurs. With carefully-sourced ingredients, Qualia Mind offers enhanced brain function that is guilt-free and top-notch.


Qualia Mind offers a comprehensive array of features, including:

→ Lasting energy → Mental clarity → Amplified willpower → Decreased procrastination → Brain nutrition → Effortless focus

Designed to be taken five days a week, Qualia Mind works best when users are getting adequate sleep and self-care. In addition to its immediate effects, it enhances long-term cognitive health as well. It does this by supporting neuron and synapse development, mitochondrial ATP, healthier cell structures, and neural complexity.


This nootropic is extremely in improving cognition and greatly enhances brain function. Some of the major benefits associated with this product include sustained energy, increased mental clarity and focus, and it provided the brain with optimal nutrition. The effects of Qualia products are most potent when those who use it ensure that they are getting enough sleep and providing themselves with the best self-care. This product is also known for improving long-term cognitive health through supporting the development of neurons and synapses as well as aiding mitochondrial ATP, cellular structure, and neural complexity. Major Ingredients: Huperzine A, Celastrus Paniculatus Seed Extract, Phosphatidylserine, Theobromine, Uridine Monophosphate, Coffeeberry® (caffeine), Vitamin D3 (Cholecalciferol), Vitamin C (Ascorbic Acid), Niacin (as Niacinamide), Vitamin B1 (Thiamine), Vitamin B6 (Pyridoxal-5-Phosphate), Vitamin B12 (Methylcobalamin), Vitamin B5 (Calcium Pantothenate), DHA (as Docosahexenoic Acid from Algae), Pyrroloquinoline Quinone (PQQ), Artichoke Stem and Leaf Extract, Bacopa monnieri Leaf Extract, Coleus forskohlii Root, Ginkgo biloba Leaf Extract, Mucuna pruriens Seed, Rhodiola rosea Root, N-Acetyl-L-Tyrosine, Taurine, L-Theanine, Acetyl-L-Carnitine, DL-Phenylalanine, Alpha GPC, Cognizin® Citicoline.

  • Needs to be cycled due to side effects from prolonged use of Huperzine A

15% OFF WITH CODE: Nchip

Brain Booster by Vital Vitamins

Price: $21.87 for 30 capsules Serving Size and Directions: Take 1 capsule daily. Brain Booster contains several high-quality ingredients that help improve mental clarity, alertness, focus, and mood.  This product is best known for its ability to enhance brain health while improving overall mood and critical thinking. Brain Booster contains Bacopa Monnieri Extract which is As a legendary Ayurvedic adaptogen and is world renowned for its ability to reduce anxiety and stress. This product delivers enough natural brain boosting nutrients through one serving to provide enough energy throughout the day and night and allows its user to function at optimal cognitive ability. Ingredients: Vitamin B12, Bacopa Monnieri Extract, Ginkgo Biloba, Rhodiola Rosea Extract, DMAE

  • Contains a healthy mix of natural nootropics without excess stimulants Contains Bacopa Monnieri Extract which has been used by Ayurvedic medical practitioners for centuries for reducing anxiety
  • May cause headaches or nausea May cause stomach bloating or gastrointestinal discomfort

Best Nootropics for Mood

Nootropics are also known as brain supplements because of their ability to enhance the functionality of brain by relieving it of stress and also stimulating or inhibiting the secretion of various neurochemicals.

Mood can also be altered through the use of nootropics.

Some nootropics are capable of improving the mood from a state of depression to a happy mood, while some are capable of getting rid of anxiety.

Whatever the case may be, it’s been proven that nootropics can help in treating mood swing.

In the broadest term, nootropics are natural supplements that are capable of stimulating or inhibiting the brain cells from secretion of various neurochemicals.

In this case, we are interested in nootropics that are capable of stimulating the secretion of neurochemicals that are responsible for mood control in the central nervous system.

For the purpose of this article, these neurotransmitters would be grouped into two, based on their function in the brain. While some are categorized as inhibitory neurotransmitter, others are excitatory neurotransmitters.

Inhibitory Neurotransmitters:

Just as the name implies; the neurotransmitters in this category plays inhibitory roles of “calming” the brain cells down. Gamma Amino Butyric (GABA) and Serotonin are the major neurotransmitters in this category.

A low level of GABA and Serotonin in the central nervous system is often associated with anxiety disorder.

Since the major role of these inhibitory neurotransmitters is to literally “calm” the neurons down as a compensation from stress or excessive usage. It’s understandable when anxiety disorder sets in due to their deficiency.

GABA functions by regulating the amount of excitatory neurotransmitters in the central nervous system.

Having too much of it in the central nervous system is not a good thing either, it may result into brain fog and unwanted sluggishness simply because the brain does not see the need to be “quick”.

Serotonin is considered one of the most important neurotransmitters in the body, it’s function span across the central nervous system and the digestive system. In the CNS, serotonin is responsible for sleep regulation, happiness, and other forms of mood control. It’s hormonal component is melatonin.

In people suffering from clinical depression, their cerebrospinal fluid has been shown to contain a relatively low level of serotonin, which is an indication that serotonin plays an important role in regulation of mood.

Excitatory Neurotransmitters:

The number of neurotransmitters in this group significantly outweighs that of inhibitory neurotransmitters. As the name implies, these neurochemicals “excites” the brain cells. The literally put the brain cell on fire, to function as actively as they can. Deficiency of these neurotransmitter has been linked to various forms of mood disorder.

Have you even seen a movie where the actor is injected with adrenaline and he suddenly gets pumped up, running several kilometers even with few gunshot wounds? Purely fiction; but that’s how adrenaline works in a sense.

Adrenaline is also known as epinephrine and it is belongs to the group of excitatory neurotransmitters. Low level of this neurotransmitter has been associated with loss of focus and fatigue. While it’s excess has been linked to various anxiety disorders, insomnia and attention disorder.

Glutamate is another major excitatory disorder. It’s major role is in memory and learning function. It’s been shown that increased level of glutamate beyond the body’s tolerable amount can result into death of brain cells.

Glutamate imbalance has also been implicated in various neurodegenerative disorder; high level of glutamate is associated with depression. Autistic patients are also known to have a significantly high level of glutamate.

L-Theanine is an amino acid similar in structure to glutamate and it is widely used in treatment of anxiety.​

Norepinephrine is another significant excitatory neurotransmitter. It’s function is a little bit dynamic as compared to other neurotransmitter. It’s mode of release determines what type of function it would perform.

A sudden massive release of norepinephrine plays a role in fight or flight decision in cases of danger. When this mode of norepinephrine release is constant, then it results into hyperactivity.

I am not sure exactly where to list the next neurotransmitter because it function both as excitatory and inhibitory neurotransmitter.

Dopamine plays critical role in various body systems. Depending upon it’s site of action, it can play either inhibitory role or excitatory role. Elevated level of dopamine has been linked to maniac episodes, delusions and pyschosis.

While low level of dopamine on the other hand is linked to depression, low self esteem and lack of motivation.

It also plays a role in memory function and it’s the chief neurotransmitter in the brain reward system, which explains why the neurotransmitter is often associated with addiction and motivation.

Histamine is another excitatory neurotransmitter, not the most popular, but it also play a role in mood regulation and other expression of emotion.

High level of histamine is associated with OCD and depression, while low level is often associated with lack of motivation, and fatigue.

Although there are several other neurotransmitters that plays supporting role in controlling the mood, the ones listed above are the key players, and their low level of high level is significantly noticeable.

Types of Mood:

Although there are several moods types, various sub-classification which I consider too complex for the scope of this post. I would simply classify the moods into two; depressed states and anxiety state. (Remember that it’s much more complex than that).

Anxiety mostly occurs when the body has too much of excitatory neurotransmitters in the brain.

Continuous state of anxiety results into maniac state as seen in people suffering from schizophrenia. While depression may arise as a result of low level of inhibitory neurotransmitter, or low level of excitatory neurotransmitter.

Imbalance of this neurotransmitter is mostly due to three major factors, which are; genetic factor, nutrition factor and environmental factor. No matter the source or etiology, the mood can still be influenced to some certain extent with nootropics.

Having discussed in details the role of each neurotransmitters and the basic type of moods, it’s safe to conclude that, the choice of nootropics greatly depends on the current state of mood and as a result there is no “all-in-all” nootropics.

What Do Nootropics do for Anxiety?

We’ve all been in a situation that warrants anxiousness, the causes might be different, but there is nothing abnormal about being anxious every once in a while. More own anxiousness is quite often when am about to take a test, travel to a new place, meet new people or when am about to check my exam result. On such occasion, I would generally be restless before I began what is causing the anxiousness, and as soon as I get started with it, the anxiety is gone.

I call this normal Anxiety because it’s a physiological condition and you shouldn’t be worried when this happens once in a while. You can take a pill of nootropics meant for anxiety if you feel the need to do so.

However, for some categories of people, it’s not a “once in a while” thing. They experience anxiety every day, all the time. Fear and restless is what defines their mood all the time, such people are said to be suffering from anxiety disorder. This disorder is categorized as a serious mental disorder, and such individual needs extensive medical attention in other to get as comfortable with life as much as possible.

Anxiety Disorder is not a sign of weakness or any other words that people might use to describe it. It’s an unwanted sickness and adequate support should be given to people suffering from such disorder. Support can however come in various dimensions, either by being with them during the dark period and helping out with basic task they don’t or can’t do on their own, or by keeping an eye on them to make sure they’re safe.

Symptoms Of Anxiety Disorder

It’s important to know the symptoms presented by anxiety disorder before you embark on taking any form of nootropics for such condition. It’s equally important that you consult a specialist to give proper diagnosis of your medical condition before you make conclusion about whether you’re suffering from anxiety disorder or not.

While these symptoms may present themselves in cases of “normal anxiety”, it should be noted that they don’t take long before disappearance and restoration of normal state of health.

Fear and Restlessness: This is one of the most common symptoms of anxiety. Such individual can’t maintain any form of calmness and it makes it incredibly difficult for them to be focused and make reasonable decision.

Sweaty Hands: This is often caused by perspiration. People with anxiety generally have sweat on their hands and feet. Sometimes, it might be cold hands and feet, it all depends on how to body choose to react with the present situation.

Insomnia: Anxiety might present itself in the form of insomnia. I have also experience this quite often, most especially when am about to make a crucial decision or embark on a journey. I usually find it very difficult to sleep the night before. Read about best melatonin supplements as a way of treating insomnia.

Apnea: This term is used in describing shortness of breath. Anxiety might present individual with the inability to breathe deeply and as such, restlessness sets in.

Xerostomia: This describes the reduction in the amount of saliva present in the mouth, resulting into dryness of mouth. This is another common symptom associated with anxiety, both in normal people and in those diagnosed with anxiety disorder.

Dizziness: This might occur as an effect of apnea of insomnia. Apnea would automatically result into low level of oxygen in the body tissue.

Occurrence of two or more of this symptoms at the same time is definitely an indication of anxiety, when the keep occurring repeatedly, then it’s safe to assume that such an individual is suffering from anxiety disorder. And it’s advisable to consult a medical expert, in such condition.

Taking nootropics for anxiety has been show to be greatly effective, and as such, this article would analyze the best nootropics for anxiety and how they work in restoring calmness in the brain.

A larger percentage of medications used in treating anxiety are classified as anti-depressants or anti-anxiety. What these medication does is to balance the neurochemicals in the brain and reduce the brain chemical responsible for anxiety to it’s normal volume.

​Recently people have been turning to the use of theanine supplement to overcome anxiety without feeling sleepy or sedated. Here is our guide on best l-theanine supplements

The brain works based on signals provided by the neurochemicals in it. Which means, when there is excess secretion of neurochemical responsible for anxiousness, then anxiety is inevitable, and as such the only way of getting rid of anxiety is either my inhibiting the production of such neurochemical (temporarily) or by stimulating the production of other neurochemicals that are capable for counteracting the effect. A larger percentage of nootropics are capable of altering the mood and bring the much needed calmness in cases of social anxiety and other common types undiagnosed of anxiety.

It’s been shown that the major cause of anxiety is low level of gamma aminobutyric acid (GABA) in the brain. GABA basically function as inhibitory neurotransmitter. They tell your brain cells to calm down. When the amount of GABA in the brain is low, your brain cell becomes over-excited, and as such anxiety sets in.

Normally, the first solution that comes to mind would be supplementing the GABA neurochemical in the brain, but the sad thing is that GABA are known to be impermeable into the brain cell, as a result of a barrier in the brain known as blood-brain barrier. This makes direct intake of GABA less effective in cases of anxiety.

The best nootropics for anxiety would therefore be a good transporter or precursor of GABA, it should be able to cross the blood brain barrier before turning into or yielding GABA. We have analyzed several nootropics as listed on amazon, we examined the component of each of them and came into conclusion on which of them is the best nootropics for anxiety.

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