Best Nootropics for Mood and Anxiety

Have you ever experienced mood swings or overwhelming anxiety? Do you constantly feel drained by everyday life or feel that you just can’t get the focus you need to stay on task? If you answered yes to any of these questions then you may want to consider taking some form of a nootropic to help you overcome these struggles.

Nootropics are nutritional supplements that enhance cognitive ability and aid overall mental health. People from all health backgrounds take nootropics to help boost their mood as well as reduce their anxiety or stress. Some of the most common issues that nootropics help with include depression, irritability, brain fog, lack of energy, nervousness, and problems with learning and memory.

If you’re searching for something that will allow you to live a happier, healthier life then nootropics might be the best option for you.  Check out the following nootropics which are best for improving mood and anxiety.

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

Comparison of the 5 Best Nootropics for Mood and Anxiety

Best Overall Nootropic for Mood and Anxiety
Mind Lab Pro®
Editor’s Choice 2
Best NAC Supplements

Best Overall Nootropic for Mood and Anxiety

Mind Lab Pro®

  • Best Nootropics for Mood and Anxiety
    Universal Nootropic
  • Best Nootropics for Mood and Anxiety
    11 Potent Nootropics
  • Best Nootropics for Mood and Anxiety
    Boosts Productivity
  • Best Nootropics for Mood and Anxiety
    Supports Calm Mindset
  • Best Nootropics for Mood and Anxiety
    Nature Identical Vitamins
Best Pharmaceutical Grade Cognitive Enhancer
Editor’s Choice 2
Best NAC Supplements

Best Pharmaceutical Grade Cognitive Enhancer


  • Best Nootropics for Mood and Anxiety
  • Best Nootropics for Mood and Anxiety
    Boosts Mood
  • Best Nootropics for Mood and Anxiety
    Enhances Productivity
  • Best Nootropics for Mood and Anxiety
    Pharmaceutical Grade
  • Best Nootropics for Mood and Anxiety
    No Caffeine
Best Nootropic for Brain Nourishment
Qualia Mind
Editor’s Choice 2
Best NAC Supplements

Best Nootropic for Brain Nourishment

Qualia Mind

  • Best Nootropics for Mood and Anxiety
    100% Vegan
  • Best Nootropics for Mood and Anxiety
    Fast-Acting Formula
  • Best Nootropics for Mood and Anxiety
    Calm Energized Focus
  • Best Nootropics for Mood and Anxiety
    6 Nootropic Compounds
  • Best Nootropics for Mood and Anxiety
    7 Neuro Vitamins
Best Nootropic for Preventing Burnout
Performance Lab Mind
Editor’s Choice 2
Best NAC Supplements

Best Nootropic for Preventing Burnout

Performance Lab Mind

  • Best Nootropics for Mood and Anxiety
    Prebiotic Nutricaps
  • Best Nootropics for Mood and Anxiety
    Vegan Friendly
  • Best Nootropics for Mood and Anxiety
    Caffeine Free
  • Best Nootropics for Mood and Anxiety
    Banned Substance Tested
  • Best Nootropics for Mood and Anxiety
    Boosts Brain Energy 13.6%

Mind Lab Pro’s Universal Nootropic

best nootropics for mood and anxiety

Price: $65 for 60 capsules Serving Size and Directions: Take 2 capsules per serving; Do not take more than 4 capsules within 24 hours. Mind Lab Pro® is a 100% natural, vegan and stimulant-free nootropic is best known for its ability to create a better mindset and mood within those who use it. Unlike other products, it doesn’t contain stimulants, such as adrafinil or those within the racetam family, making it the ideal product for those who are stimulant-sensitive or those who prefer a more relaxed state when trying to focus. It is considered to be a “universal nootropic” since it contains 11 major ingredients that support a full spectrum of cognitive functions. Major Ingredients: 250 mg Citicoline (Cognizin), 175 mg N-Acetyl-L-Tyrosine, 100 mg L-Theanine (Suntheanine), 100 mg Phosphatidylserine (Sharp PS Green), 150 mg Bacopa Monnieri (45% bacosides), 75 mg Maritime Pine Bark Extract, 500 mg Lion’s Mane Mushroom, 50 mg Rhodiola rosea (3% rosavins & 1% salidroside), 2.5 mg Vitamin B6, 100 mcg Vitamin B9, 7.5 mcg Vitamin B12.


  • Promotes motivation and a better mood Stimulant free


  • May lead to headaches or dizziness May cause jitteriness

Modafinil by ModafinilXL

buy modafinil online

Modafinil is recognized as one of the most efficient brain superchargers and artificial cognitive enhancers around the world today.

Although it’s not a nootropic, Modafinil is a pharmaceutical-grade drug that’s used by people, such as Silicon Valley entrepreneurs, students, and night-shift workers, to help sharpen focus as well as improve cognitive function and stay on task.

Modafinil is offered in a variety of forms and quantities. Three of the most popular forms of Modafinil include Modvigil, Modalert, and Artvigil, all of which can be bought in quantities ranging from 10 to 500 pills.

Those who order Modafinil should keep in mind that the average turn-around time for shipping is between 3-4 weeks. Thus, it’s generally best to order quantities of 200 or more pills at one time to have a large enough supply.


  • Easy-to-Take
  • Single-Ingredient
  • Boosts mood and productivity


  • 33% of users report experiencing headaches
  • 11% of users report experiencing nausea
  • Known to interact with 520 pharmaceutical ingredients

Qualia Mind by Neurohacker Collective

Best Nootropics for Mood and Anxiety

Price: $139.00 for 154 capsules Serving Size and Directions: Take 7 capsules with water prior to eating; Limit use to 5 days a week. About Qualia Mind

This top-selling supplement from Neurohacker Collective is known for being a high-quality, extremely effective nootropic for improving cognition. Qualia supplements are designed through thousands of hours in research and development by top scientists, and are used by top athletes, professors and entrepreneurs. With carefully-sourced ingredients, Qualia Mind offers enhanced brain function that is guilt-free and top-notch.


Qualia Mind offers a comprehensive array of features, including:

→ Lasting energy → Mental clarity → Amplified willpower → Decreased procrastination → Brain nutrition → Effortless focus

Designed to be taken five days a week, Qualia Mind works best when users are getting adequate sleep and self-care. In addition to its immediate effects, it enhances long-term cognitive health as well. It does this by supporting neuron and synapse development, mitochondrial ATP, healthier cell structures, and neural complexity.


This nootropic is extremely in improving cognition and greatly enhances brain function. Some of the major benefits associated with this product include sustained energy, increased mental clarity and focus, and it provided the brain with optimal nutrition. The effects of Qualia products are most potent when those who use it ensure that they are getting enough sleep and providing themselves with the best self-care. This product is also known for improving long-term cognitive health through supporting the development of neurons and synapses as well as aiding mitochondrial ATP, cellular structure, and neural complexity.

Major Ingredients: Huperzine A, Celastrus Paniculatus Seed Extract, Phosphatidylserine, Theobromine, Uridine Monophosphate, Coffeeberry® (caffeine), Vitamin D3 (Cholecalciferol), Vitamin C (Ascorbic Acid), Niacin (as Niacinamide), Vitamin B1 (Thiamine), Vitamin B6 (Pyridoxal-5-Phosphate), Vitamin B12 (Methylcobalamin), Vitamin B5 (Calcium Pantothenate), DHA (as Docosahexenoic Acid from Algae), Pyrroloquinoline Quinone (PQQ), Artichoke Stem and Leaf Extract, Bacopa monnieri Leaf Extract, Coleus forskohlii Root, Ginkgo biloba Leaf Extract, Mucuna pruriens Seed, Rhodiola rosea Root, N-Acetyl-L-Tyrosine, Taurine, L-Theanine, Acetyl-L-Carnitine, DL-Phenylalanine, Alpha GPC, Cognizin® Citicoline.



  • Needs to be cycled due to side effects from prolonged use of Huperzine A

15% OFF WITH CODE: Nchip

Performance Lab Mind

Best Nootropics for Mood and AnxietyMind by Performance Lab is a cognitive enhancement supplement which supports focus, memory, speed, and motivation. Unlike other products which just provide a quick rush of energy, Mind provides long-lasting energy as well as  helps your brain recover from intense mental exertion.

Mind is formulated with Cognizin® Citicoline, Sharp-PS® Green, Ajipure® L-Tyrosine and Maritime Pine Bark Extract. Additionally, it’s vegan friendly and free of allergens and additives. 

About Performance Lab 

Performance Lab offers a wide variety of training and nutritional supplements which aid human performance and promote all-around health.  Its supplements provide support for better sleep, vision, cognition, and energy as well as enhance muscle growth, strength, endurance, and training intensity.

Performance Lab uses premier nutrition technologies in order to revolutionize healthy performance nutrition as well as to provide the highest quality performance supplements available on the market. This company provides one of the world’s most sophisticated nutritional supplement systems for optimizing daily performance and long-range health.

Unique Features

Boosts Brain Cell Membrane Formation and Energy

Cognizin® has the potential to increase brain cell membrane formation by 26% and brain energy by 13.6%.

Cognizin® + Sharp-PS® Green Combined 

Cognizin® + Sharp-PS® Green supply twice the support for memory, mood, learning and long-range brain health when compared to other products on the market.

Contains the Highest-Potency Maritime Pine Bark Extract on the Market

Performance Lab® Mind Maritime Pine Bark Extract contains 95% antioxidant proanthocyanidins which makes it the most potent nootropic pine bark extract in the world.


  • Contains powerful combination of ingredients
  • Ingredients have high purity
  • Improves wide range of cognitive benefits 


  • Somewhat expensive
  • Can only purchase on company website
  • No caffeine


Best Nootropics for Mood and Anxiety

NooCube contains a synergistic blend of key nootropics that enhance focus, increase mental speed, and support memory.

This product provides a way to safely and effectively improve your cognitive functioning with its powerful blend of vitamins, amino acids, and other essential building blocks for a well-functioning brain.

The NooCube formula contains seven powerful ingredients that are designed to improve all-around cognitive function.

These ingredients include Alpha GPC, Huperzine A, Cat’s Claw, Bacopa, Oat Straw, L-Theanine, and L-Tyrosine.

Both L-Theanine and L-Tyrosine are known to aid those who suffer from mood swings or experience bouts of anxiety. L-theanine creates a relaxed but alert feeling while L-tyrosine plays a key role in mental alertness and focus, especially during times of extreme stress.

Adults should take 2 NooCube capsules with breakfast each morning. It is recommended to start off with 2 capsules per day and not exceed 4 capsules per day.

Noocube is best for people who are looking to enhance their focus and better manage work-related anxiety. NooCube is most popular among business executives, elite athletes, college students, and those who are in need of a product to help streamline their productivity.


  • 7 Key Ingredients
  • Enhances all-around cognitive function
  • Only 2 capsules


  • May interact with certain medications
  • Some people may require up to 4 capsules per day

Best Nootropics for Mood

Nootropics are also known as brain supplements because of their ability to enhance the functionality of brain by relieving it of stress and also stimulating or inhibiting the secretion of various neurochemicals.

Mood can also be altered through the use of nootropics.

Some nootropics are capable of improving the mood from a state of depression to a happy mood, while some are capable of getting rid of anxiety.

Whatever the case may be, it’s been proven that nootropics can help in treating mood swing.

In the broadest term, nootropics are natural supplements that are capable of stimulating or inhibiting the brain cells from secretion of various neurochemicals.

In this case, we are interested in nootropics that are capable of stimulating the secretion of neurochemicals that are responsible for mood control in the central nervous system.

For the purpose of this article, these neurotransmitters would be grouped into two, based on their function in the brain. While some are categorized as inhibitory neurotransmitter, others are excitatory neurotransmitters.

Inhibitory Neurotransmitters 

Just as the name implies; the neurotransmitters in this category plays inhibitory roles of “calming” the brain cells down. Gamma Amino Butyric (GABA) and Serotonin are the major neurotransmitters in this category.

A low level of GABA and Serotonin in the central nervous system is often associated with anxiety disorder.

Since the major role of these inhibitory neurotransmitters is to literally “calm” the neurons down as a compensation from stress or excessive usage. It’s understandable when anxiety disorder sets in due to their deficiency.

GABA functions by regulating the amount of excitatory neurotransmitters in the central nervous system.

Having too much of it in the central nervous system is not a good thing either, it may result into brain fog and unwanted sluggishness simply because the brain does not see the need to be “quick”.

Serotonin is considered one of the most important neurotransmitters in the body, it’s function span across the central nervous system and the digestive system. In the CNS, serotonin is responsible for sleep regulation, happiness, and other forms of mood control. It’s hormonal component is melatonin.

In people suffering from clinical depression, their cerebrospinal fluid has been shown to contain a relatively low level of serotonin, which is an indication that serotonin plays an important role in regulation of mood.

Excitatory Neurotransmitters:

The number of neurotransmitters in this group significantly outweighs that of inhibitory neurotransmitters. As the name implies, these neurochemicals “excites” the brain cells. The literally put the brain cell on fire, to function as actively as they can. Deficiency of these neurotransmitter has been linked to various forms of mood disorder.

Have you even seen a movie where the actor is injected with adrenaline and he suddenly gets pumped up, running several kilometers even with few gunshot wounds? Purely fiction; but that’s how adrenaline works in a sense.

Adrenaline is also known as epinephrine and it is belongs to the group of excitatory neurotransmitters. Low level of this neurotransmitter has been associated with loss of focus and fatigue. While it’s excess has been linked to various anxiety disorders, insomnia and attention disorder.

Glutamate is another major excitatory disorder. It’s major role is in memory and learning function. It’s been shown that increased level of glutamate beyond the body’s tolerable amount can result into death of brain cells.

Glutamate imbalance has also been implicated in various neurodegenerative disorder; high level of glutamate is associated with depression. Autistic patients are also known to have a significantly high level of glutamate.

L-Theanine is an amino acid similar in structure to glutamate and it is widely used in treatment of anxiety.​

Norepinephrine is another significant excitatory neurotransmitter. It’s function is a little bit dynamic as compared to other neurotransmitter. It’s mode of release determines what type of function it would perform.

A sudden massive release of norepinephrine plays a role in fight or flight decision in cases of danger. When this mode of norepinephrine release is constant, then it results into hyperactivity.

I am not sure exactly where to list the next neurotransmitter because it function both as excitatory and inhibitory neurotransmitter.

Dopamine plays critical role in various body systems. Depending upon it’s site of action, it can play either inhibitory role or excitatory role. Elevated level of dopamine has been linked to maniac episodes, delusions and pyschosis.

While low level of dopamine on the other hand is linked to depression, low self esteem and lack of motivation.

It also plays a role in memory function and it’s the chief neurotransmitter in the brain reward system, which explains why the neurotransmitter is often associated with addiction and motivation.

Histamine is another excitatory neurotransmitter, not the most popular, but it also play a role in mood regulation and other expression of emotion.

High level of histamine is associated with OCD and depression, while low level is often associated with lack of motivation, and fatigue.

Although there are several other neurotransmitters that plays supporting role in controlling the mood, the ones listed above are the key players, and their low level of high level is significantly noticeable.

Types of Mood:

Although there are several moods types, various sub-classification which I consider too complex for the scope of this post. I would simply classify the moods into two; depressed states and anxiety state. (Remember that it’s much more complex than that).

Anxiety mostly occurs when the body has too much of excitatory neurotransmitters in the brain.

Continuous state of anxiety results into maniac state as seen in people suffering from schizophrenia. While depression may arise as a result of low level of inhibitory neurotransmitter, or low level of excitatory neurotransmitter.

Imbalance of this neurotransmitter is mostly due to three major factors, which are; genetic factor, nutrition factor and environmental factor. No matter the source or etiology, the mood can still be influenced to some certain extent with nootropics.

Having discussed in details the role of each neurotransmitters and the basic type of moods, it’s safe to conclude that, the choice of nootropics greatly depends on the current state of mood and as a result there is no “all-in-all” nootropics.

What Do Nootropics do for Anxiety?

We’ve all been in a situation that warrants anxiousness, the causes might be different, but there is nothing abnormal about being anxious every once in a while. More own anxiousness is quite often when am about to take a test, travel to a new place, meet new people or when am about to check my exam result. On such occasion, I would generally be restless before I began what is causing the anxiousness, and as soon as I get started with it, the anxiety is gone.

I call this normal Anxiety because it’s a physiological condition and you shouldn’t be worried when this happens once in a while. You can take a pill of nootropics meant for anxiety if you feel the need to do so.

However, for some categories of people, it’s not a “once in a while” thing. They experience anxiety every day, all the time. Fear and restless is what defines their mood all the time, such people are said to be suffering from anxiety disorder. This disorder is categorized as a serious mental disorder, and such individual needs extensive medical attention in other to get as comfortable with life as much as possible.

Anxiety Disorder is not a sign of weakness or any other words that people might use to describe it. It’s an unwanted sickness and adequate support should be given to people suffering from such disorder. Support can however come in various dimensions, either by being with them during the dark period and helping out with basic task they don’t or can’t do on their own, or by keeping an eye on them to make sure they’re safe.

Symptoms Of Anxiety Disorder

It’s important to know the symptoms presented by anxiety disorder before you embark on taking any form of nootropics for such condition. It’s equally important that you consult a specialist to give proper diagnosis of your medical condition before you make conclusion about whether you’re suffering from anxiety disorder or not.

While these symptoms may present themselves in cases of “normal anxiety”, it should be noted that they don’t take long before disappearance and restoration of normal state of health.

Fear and Restlessness: This is one of the most common symptoms of anxiety. Such individual can’t maintain any form of calmness and it makes it incredibly difficult for them to be focused and make reasonable decision.

Sweaty Hands: This is often caused by perspiration. People with anxiety generally have sweat on their hands and feet. Sometimes, it might be cold hands and feet, it all depends on how to body choose to react with the present situation.

Insomnia: Anxiety might present itself in the form of insomnia. I have also experience this quite often, most especially when am about to make a crucial decision or embark on a journey. I usually find it very difficult to sleep the night before. 

Apnea: This term is used in describing shortness of breath. Anxiety might present individual with the inability to breathe deeply and as such, restlessness sets in.

Xerostomia: This describes the reduction in the amount of saliva present in the mouth, resulting into dryness of mouth. This is another common symptom associated with anxiety, both in normal people and in those diagnosed with anxiety disorder.

Dizziness: This might occur as an effect of apnea of insomnia. Apnea would automatically result into low level of oxygen in the body tissue.

Occurrence of two or more of this symptoms at the same time is definitely an indication of anxiety, when the keep occurring repeatedly, then it’s safe to assume that such an individual is suffering from anxiety disorder. And it’s advisable to consult a medical expert, in such condition.

Taking nootropics for anxiety has been show to be greatly effective, and as such, this article would analyze the best nootropics for anxiety and how they work in restoring calmness in the brain.

A larger percentage of medications used in treating anxiety are classified as anti-depressants or anti-anxiety. What these medication does is to balance the neurochemicals in the brain and reduce the brain chemical responsible for anxiety to it’s normal volume.

​Recently people have been turning to the use of theanine supplement to overcome anxiety without feeling sleepy or sedated. Here is our guide on best l-theanine supplements

The brain works based on signals provided by the neurochemicals in it. Which means, when there is excess secretion of neurochemical responsible for anxiousness, then anxiety is inevitable, and as such the only way of getting rid of anxiety is either my inhibiting the production of such neurochemical (temporarily) or by stimulating the production of other neurochemicals that are capable for counteracting the effect. A larger percentage of nootropics are capable of altering the mood and bring the much needed calmness in cases of social anxiety and other common types undiagnosed of anxiety.

It’s been shown that the major cause of anxiety is low level of gamma aminobutyric acid (GABA) in the brain. GABA basically function as inhibitory neurotransmitter. They tell your brain cells to calm down. When the amount of GABA in the brain is low, your brain cell becomes over-excited, and as such anxiety sets in.

Normally, the first solution that comes to mind would be supplementing the GABA neurochemical in the brain, but the sad thing is that GABA are known to be impermeable into the brain cell, as a result of a barrier in the brain known as blood-brain barrier. This makes direct intake of GABA less effective in cases of anxiety.

The best nootropics for anxiety would therefore be a good transporter or precursor of GABA, it should be able to cross the blood brain barrier before turning into or yielding GABA. We have analyzed several nootropics as listed on amazon, we examined the component of each of them and came into conclusion on which of them is the best nootropics for anxiety.


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[1] Gajcy, K., Lochynski, S., & Librowski, T. (2010). A role of GABA analogues in the treatment of neurological diseases. Current medicinal chemistry, 17(22), 2338-2347.

[2] Rashmi, D., Zanan, R., John, S., Khandagale, K., & Nadaf, A. (2018). γ-aminobutyric acid (GABA): Biosynthesis, role, commercial production, and applications. In Studies in Natural Products Chemistry (Vol. 57, pp. 413-452). Elsevier.

[3] Savage, K., Firth, J., Stough, C., & Sarris, J. (2018). GABA‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytotherapy Research, 32(1), 3-18.

[4] Valenzuela, J. A., Flórez, A. B., Vázquez, L., Vasek, O. M., & Mayo, B. (2019). Production of γ-aminobutyric acid (GABA) by lactic acid bacteria strains isolated from traditional, starter-free dairy products made of raw milk. Beneficial microbes, 10(5), 579-587.

[5] Boonstra, E., de Kleijn, R., Colzato, L. S., Alkemade, A., Forstmann, B. U., & Nieuwenhuis, S. (2015). Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Frontiers in psychology, 6, 1520.

[6] Yoto, A., Murao, S., Motoki, M., Yokoyama, Y., Horie, N., Takeshima, K., ... & Yokogoshi, H. (2012). Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino Acids, 43(3), 1331-1337.

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Nicole Gleichman

Nicole Gleichmann is an avid self-improvement enthusiast who loves to help her readers become the best versions of themselves. For the past five years, she's dedicated her life as a wellness writer and nutrition coach to learning everything there is to know about human potential. In her free time, she spends her days traversing the mountains, playing with her dogs, and traveling the world in search of new perspectives.
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