Flmodafinil NOOTROPICS: Benefits, Uses, Dosage

Flmodafinil, a derivative of Modafinil, possesses a greater half-life and bioavailability due to additional Fluorine atoms. This nootropic is really potent in making you feel active, energized, productive, alert and making you feel less sleepy.

Compound Summary

Class of Compound


Mechanism of Action

It works as a D2 agonist and is a selective dopamine reuptake inhibitor. It only impacts the dopaminergic system and not any other neurotransmitter levels. Besides, the addition of 2 extra Fluorine atoms increases its half-life as well as the bioavailability.

Street Names

CRL 40,940 , Flmodafinil, Bisfluoromodafinil, Laufumide


Keeps dopamine levels high, More alert, Reduces sleep duration

Side Effects and Dangers

Still under phase 1 clinical trials, May lead to insomnia, Mild risk of hypertension

Chemical Structure

People have been using nootropics a lot lately to enhance their cognitive capabilities, increase their state of mental alertness, and boost their overall brain functioning.

As the demand for nootropics is increasing, so does the research and development on the new varieties of nootropic drugs.

If you are a fan of nootropics, you must have heard about the most famous and highly used “Modafinil.” Fortunately, scientists have come up with a derivative of Modafinil called “Flmodafinil.” Research on Flmodafinil suggests that it has better bioavailability than its parent drug as well as more potency.

Let’s review Flmodafinil in this article, and I’ll make sure to include everything that you should know before deciding whether to start cycling Flmodafinil to upregulate the brain’s working or not.

What Is Flmodafinil?

Modafinil (1), also known as a “smart drug,” was originally developed to cure sleeping disorders such as idiopathic hypersomnia and narcolepsy (2). Later on, it was widely used as a productivity hack and to enhance the functioning of certain brain areas.

Flmodafinil, a recent development, is ideally an analog of Modafinil. What makes Flmodafinil structurally different is the addition of 2 Fluorine atoms at different sites.

Due to this, people also call it bis fluoro modafinil and laufumide. The chemical name of Flmodafinil is CRL-40,940 (3).

Note that being under phase 1 clinical trials since 2015, this bisfluoro analog of Modafinil is only hypothesized based on the structural differences to be more potent than its parent drug.

#1 Flmodafinil

Amino Asylum – CRL-40940 (Flmodafinil)

This is a bisfluoro analog of Modafinil, and healthily dosed at 50mg/ml. This version of Modafinil claims to have less side effects while also being more effective as well. Flmodafinil has been known to increase cognitive function and mental clarity.

Amino Asylum is known for good quality products, and their Nootrtopics have excellent reviews both on their site, as well as on Reddit.

Flmodafinil NOOTROPICS: Benefits, Uses, Dosage

Amino Asylum

Amino Asylum might be a young-ish company but has been rising in popularity. Not only do they have quite a wide variety of products ranging from Amino Acids, Prohormones, SARMs, Peptides, and other Research Chemicals, but they have exceptional quality.

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  • Provides more than just Research chemicals
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  • Their partners also offer high quality gym based supplements
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How Does Flmodafinil Work?

Nootropics usually alter the functioning of the brain by regulating the levels of neurotransmitters in the brain.

Like Modafinil, the Flmodafinil also acts as a selective dopamine reuptake inhibitor and is a potential agonist of D2 receptors (4). This results in the amplified working of dopamine in certain areas of the body, thereby enhancing cognitive abilities as well as aiding productivity.

The direct working of Flmodafinil is only limited to the dopaminergic system, and it doesn’t seem to affect the levels of other neurotransmitters significantly.

Perhaps what really distinguishes Flmodafinil from its parent drug Modafinil is the half-life and bioavailability in the body. These two characteristics are very important in determining the potency and efficacy of any drug.

The pharmacokinetics of CRL 40,940 or Flmodafinil suggests that it has a 40% longer half-life than Modafinil, thus having a lasting impact on the body.

Besides, the addition of 2 Fluorine atoms increases the strength of the drug by as much as 4 times, giving intense changes in the body. Better bioavailability of Flmodafinil also means that it can be readily absorbed in the body compared to Modafinil.

Benefits Of Flmodafinil

As Flmodafinil works by acting as a selective dopamine reuptake inhibitor, it makes sure to always keep dopamine levels high. Higher dopamine levels keep the individual more geared up, confident, and alert.

Flmodafinil plays with the neurochemicals in such a way as to create a sense of wakefulness, makes the individuals feel less sleepy, and minimize the feeling of fatigue and lethargy.

As a derivative of Modafinil, which was originally used to treat sleep conditions, Flmodafinil makes sure to treat sleeping disorders and also reduce any side effects experienced due to hyposomnia.

CRL 40,940 is such a potential nootropic that it has tremendous effects on cognitive capabilities (5). It helps establish new neuronal connections that enhances long-term memory, spatial strength and gives the subject a surge in decisive powers.

With a considerable impact on alertness, concentration, focus, and attention, Flmodafinil predominantly increases the quality of life and work with better mental clarity.

As dopamine levels are kept high, you often feel energetic and motivated after Flmodafinil dosage. Therefore, there is a strong boost in productivity as well as determination in performing the days tasks.

This CRL 40,940 also acts as an anti-aggressive nootropic, thereby diminishing any feeling of emotional disturbance and uneasiness.

Is Flmodafinil Legal?

Although Modafinil is itself a regulated drug that requires a prescription to buy, its analogs are not yet restricted. Therefore, you can buy Flmodafinil from many online websites.

Note that Flmodafinil has been under phase 1 clinical trials since 2015.

Who Should Use Flmodafinil

As a potential nootropic, I would recommend Flmodafinil to everyone who is looking forward to hacking their productivity and cognitive capabilities.

Perhaps the biggest use of Flmodafinil is to solve sleep disorders. Flmodafinil will definitely help you reduce your sleep duration.

Also, if you have concentration and focus issues, this nootropic can help you achieve optimal attentiveness and alertness.

Do consult your doctor if you are planning to use Flmodafinil for any other purposes.

Forms Of Flmodafinil

You can find Flmodafinil in various forms, such as tablets, powder form as well as in a solution.

A lot of people prefer the tablet form of intake because it is easier to manage the dosage, and it makes it easier not to skip the dosage as it is portable.

The powder form of intake is widely available in the market and also relatively expensive too.

If you don’t prefer these two forms of intake, you can use Flmodafinil’s solution but make sure to first convert the volumes into the dosage you have been prescribed.

How To Use Flmodafinil

While it is easier to use the tablets and powder form of Flmodafinil, the liquid form will have to be used via a liquid dropper.

Make sure to fill the dropper with the right volume of Flmodafinil and consume it!

Flmodafinil Dosage

The addition of extra 2 Fluorine atoms increases the strength of Flmodafinil by 4 times relative to Modafinil. Therefore, a little dosage will prove to be very effective.

Another important thing to know before deciding on dosage is that Flmodafinil specifically targets the dopamine receptors in the brain only, so you don’t have to worry about body-weight dependent dosage guidelines.

The average dose that the majority of people are consuming is between 150mg to 200mg. But this is for people who have been using nootropics for a long time.

If you are an absolute beginner, I would strongly recommend you start with 25mg to 50mg of Flmodafinil. Once your body gets accustomed to the use of this therapeutic nootropic, then maybe you should increase your dosage.

Flmodafinil Cycling

It should only be used 2-3 times per week to minimize any risk of developing side effects.

If you think that increasing the dosage or the frequency of intake will help you experience optimal benefits safety, then you may be wrong.

The feeling of euphoria after Flmodafinil intake is real, so staying within narrow limits is very important.

Flmodafinil Stack

Being a potential dopamine reuptake inhibitor nootropic, you can stack Flmodafinil with other products to experience maximum benefits.

The most obvious and logical stack is caffeine. As caffeine also plays with the wiring of the brain and helps you stay awake, a small dosage of caffeine with Flmodafinil can create the same yet strong effect.

Naltrexone (6) and L-theanine are some of the common compounds to stack Flmodafinil with.

But in my opinion, I would not recommend any stacking because Flmodafinil is itself a strong nootropic, and an adequate amount of its dosage will be enough.

Flmodafinil Experiences

To know about what people had to say about Flmodafinil, I checked out a couple of forums. Below you will find some of the reviews left by people regarding their experience with Flmodafinil.

J-Mac says,

“I take this stacked with caffeine, choline supplement and noopept and will keep you focused for hours. The Flmodafinil is the driving factor with a stimulant-like effects. Be sure to dose correctly. I weigh it out it to be exact. Right at 100 mg does the trick for me but a newbie may want to start with 50mg or less. Great stuff.”

Michael K says,

“Ok I opened my other container of Flmodafanil.

I took about 50 scoops and I feel more awake.”

Johnny P51 commented,

“I have Flmodafinil, it seems a little inconsistent to me. Some days I notice it increases my productivity and overall sharpness for lack of a better description and other days it isn’t more than a bit of a pick me up that fades in the afternoon after a morning dose.”

Best Time To Take Flmodafinil

Ideally, Flmodafinil should be taken in the morning owing to its longer half-life.

In cases when an individual is a night worker, it is preferred to take Flmodafinil one hour prior to work. But in that case, it may affect your sleep timings after your night shift is over.

In fact, the effects of Flmodafinil are so prolonged that you will have to be extremely precise with your dosage criteria.

Also, the Flmodafinil intake causes a boost in excitement levels, so you will have to be mindful of that too.

Flmodafinil Side Effects

As everyone says, there is no gain without pain!

One of the strong points of Flmodafinil is that it has a longer half-life. This is one of the drawbacks too, because it can interfere with the sleep cycle at the later stages, leading to insomnia.

Other common side effects include anxiety, diarrhea, indigestion, nausea, and a runny nose.

Some of the people also reported mild hypertension and headaches.

You will have to be extremely careful while deciding on the dosage because higher dosages increase the risk of side effects.

Where Can I Buy Flmodafinil?

You will see a lot of online stores selling Flmodafinil. This is primarily because of the growing popularity of this nootropic, but it is very important to choose a trusted vendor to buy Flmodafinil from.

I would recommend you buy from Amino Asylum not only because of their genuine and pure products but also because of their extremely good customer service. Let’s quickly review their product before going any further.

Flmodafinil vs. Other Compounds

Flmodafinil vs. Modafinil

While Flmodafinil is a derivative of Modafinil, there are significant differences in the half-life and bioavailability of both the nootropics.

Modafinil has a shorter half-life and possesses lower bioavailability. This is primarily due to the difference in the number of Fluorine atoms attached.

Thus, one can logically conclude that Flmodafinil is more potent as compared to its parent nootropic.

Adrafinil vs. Flmodafinil

Adrafinil (7) is a pro-drug of Modafinil, which means that it is metabolized into Modafinil in the body.

It doesn’t contain any Fluorine groups and is, therefore, less effective in its action.

Is Flmodafinil Legit?

Considering that it is a derivative of Modafinil, a “smart drug,” we can expect it to increase productivity, alertness, and concentration powers.

The reviews of the people also suggest that Flmodafinil seems to be legit and fully functional. The only concern that I have is regarding dosage guidelines because of a sudden surge in the feeling of euphoria as well as the long-term side effects of the Flmodafinil.

I really hope that the phase 1 clinical trials bring some positive outcomes regarding this prospective nootropic Flmodafinil.

Is Flmodafinil legal in the USA?

If you are above 18 years of age, you can buy Flmodafinil.

Is Flmodafinil water soluble?

Flmodafinil is poorly soluble in water and poorly soluble in ethanol.

How much is Flmodafinil dosage safe?

Well, it depends if you are a beginner or a pro. Small doses of Flmodafinil are safe to start with (25mg-50mg), then boost your dosage.

Does Flmodafinil affect the liver?

The answer to this is Yes, it might! It may elevate the liver enzymes slightly, leading to inflammation.

What is FL modafinil?

CRL-40,940 (also known as flmodafinil, bisfluoromodafinil and lauflumide) is the bis fluoro analog of modafinil.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it, you can also email is at coaching@muscleandbrawn.com.

1- https://pubmed.ncbi.nlm.nih.gov/16669720/
2- https://pubmed.ncbi.nlm.nih.gov/22249574/
3- https://pubmed.ncbi.nlm.nih.gov/27928893/
4- https://pubmed.ncbi.nlm.nih.gov/9457173/
5- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516264/
6- https://pubmed.ncbi.nlm.nih.gov/30521232/
7- https://pubmed.ncbi.nlm.nih.gov/33457050/

Kartik Kumar Rathi

Kartik is a Doctor in training currently in his third year of medical school with the ultimate goal of becoming a successful cardiologist, he currently contributes to health blogs, research papers and also founded a social health startup to help educate others.
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