Best Modafinil Alternatives

Modafinil, a “smart drug” that has revolutionalized the world of nootropics since its introduction in the market, is also known to treat disorders such as narcolepsy and OSA. However, it is always best to know about other best and safer alternatives that you can consider. Today I talk about the best modafinil synthetic as well as natural alternatives. Read through the end to know about the broad spectrum!

With stressful lives and disturbing work schedules, it is becoming increasingly difficult for people to have a healthy mind and improved brain health. In the midst of running behind getting our work done and meeting deadlines, we often compromise our mental health, leading to different complications. 

Because of this, the use of smart drugs among people has increased, with modafinil being the most common one. 

Modafinil is a psychostimulant, chemically known as (2-[(diphenylmethyl) sulfinyl] acetamide). The drug has a powerful impact on our sleep cycle and thus has several neuroprotective properties associated with it. 

The working mechanism of modafinil is still a matter of research and is prone to investigation. Nonetheless, several studies have presented hypotheses regarding the matter. 

According to clinical studies, modafinil works by regulating the levels of different neurotransmitters present in our central nervous system. Scientists believe that modafinil works as a selective reuptake inhibitor of two of the main excitatory neurotransmitters, i.e., Dopamine and Norepinephrine. 

Certain studies also indicate an increased level of histamine in our bodies. 

Modafinil helps you stay awake, improves obstructive sleep apnea, is also used as a treatment option in narcolepsy, and thus leads to increased productivity and efficiency at work. 

However, with the increased use of modafinil, pharmaceuticals have developed several other drugs with modafinil as their parent drug. Head over to the following sections and know more about some of the best modafinil alternatives. 

What Are The Best Modafinil Alternatives? 

Modafinil is one of the best cognitive enhancers of all time. Its potential to have an optimistic impact on our nervous system is commendable. However, other such drugs lead to similar beneficial effects as modafinil. 

Some of the best modafinil alternatives are listed below. 

  • Adrafinil 
  • Flmodafinil 
  • Armodafinil 
  • Methylphenidate 
  • Mind Lab Pro


Adrafinil is a prodrug that is metabolized in vivo to modafinil. i.e., it leads to increased quantities of modafinil levels inside our body. However, studies suggest that adrafinil’s potency is less than that of modafinil. 

Nevertheless, supplementation with adrafinil curtails a wide variety of benefits as well. Adrafinil is a psychostimulant or better known as a synthetic nootropic. This smart drug is used for multiple purposes around the globe. 

Research testifies the use of adrafinil in treating excessive sleepiness instead of making someone hyperactive. Much like modafinil, adrafinil encourages wakefulness and brain clarity and thus leads to a positive impact on mental performance. 

The exact mechanism of action of adrafinil isn’t clear-cut. However, considering that it’s a prodrug of modafinil, it makes sense that it may as well work through histaminergic signaling. But again, strong evidence and research are required to know more about its work.
The standard dosage of adrafinil ranges somewhere between 600-1200 mg. It is advised not to take adrafinil during the morning or afternoon as it might cause a hindrance in sleep. It is recommended to take adrafinil thrice a week for five months. 


  • Promotes wakefulness and mind clarity 
  • Side Effects are not severe and often rare


  • Low potency than modafinil 
  • Not used in narcolepsy 


With modafinil already on the market and being used as the most common nootropic among people, scientists came up with a more potent drug called flmodafinil. Research says that flmodafinil has increased bioavailability than modafinil itself. 

Flmodafinil is structurally an analog of modafinil with the only difference of two fluorine atoms present in the former. Thus, flmodafinil is widely known as bis fluoro modafinil and laufamide. 

Studies believe that flmodafinil works by increasing the extracellular dopamine levels by acting as a selective dopamine reuptake inhibitor.

Henceforth, improved dopamine levels promote awakeness, confidence, and alertness alongside reducing fatigue. 

Flmodafinil being a nootropic helps in long-term memory and focus and increases attention span, thereby improving the quality of life. 

The standard dosage of flmodafinil is, on average, between 150-200 mg. However, if you’re a beginner and have just started with flmodafinil supplementation, starting with 25-50 mg is strongly recommended. Your body needs to get acquainted with a smart drug before switching to a higher dosage. 


  • Increased alertness and wakefulness 
  • More strong and potent than modafinil 
  • It can even work best in low doses too 


  • Might cause Insomnia
  • Anxiety and headaches are reported by the users 


Armodafinil is one of the medications considered as wakefulness-promoting agents. It is famously known for its positive impact on obstructive sleep apnea, shift work sleep disorder, and even narcolepsy. 

However, as the saying goes, there’s no gain without pain; armodafinil is also associated with certain side effects. This includes headache, nausea, insomnia, fatigue, and rashes. Minor cases of depression have also been reported with armodafinil supplementation. 

Armodafinil is strongly contraindicated in patients with a history of myocardial infarction, angina, or cardiac ischemia. 
Armodafinil is usually given for up to 12 weeks. The dosage ranges differ according to the causes behind the intake of armodafinil.

Nonetheless, they are most commonly anywhere between 50 mg to 250 mg. You need to have your doctor be aware of all your allergies before starting armodafinil medication. 


  • Improves obstructive sleep apnea, shift work sleep disorder, and narcolepsy
  • It is one of the wakefulness-promoting agents 


  • Adverse effects
  • It is contraindicated in certain heart conditions 

Mind Lab Pro

Mind Lab Pro is one of the most widely used smart drugs and a potent alternative to modafinil. 

Mind Lab Pro is formulated through multiple natural ingredients making it safe for intake with virtually no side effects. 

These ingredients include L-theanine, Bacopa monnieri, maritime pine bark extract, etc. the drug helps strengthen the overall brain health and is used as a supplement.


  • More superior to modafinil 
  • The majority of its ingredients are natural 


  • It would be best if you cycle this supplement i.e., take time on and off 
Best Modafinil Alternatives

Methylphenidate – Controlled Substance

Methylphenidate, unlike modafinil, is a controlled drug. Thus it needs additional legal requirements and prescriptions for you to be able to get a hold of this drug.

It is more importantly used by people looking to improve their cognition and concentration levels. People seeking to stay awake for longer periods and improve motivation often resort to Methylphenidate. 

Methylphenidate like modafinil also increases dopamine levels in our bodies and is subsequently used as a treatment option in narcolepsy alongside modafinil; however, it is not licensed to be used. 

Under a medical professional’s prescription, Methylphenidate is used in ADHD as well. 


  • Improves concentration and motivation level
  • Helps you stay awake for long  


  • It is a controlled drug 
  • Not licensed to be used in narcolepsy 

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How Did We Choose the Best Modafinil Alternative?

We have seen many customers going through the hassle of researching different nootropics for their health. Because of strong frustration, users often don’t end up with any satisfactory results. This is how we enter the picture!

Muscle and Brawn, since its beginning, has always prioritized their customers over everything else. Thus, we ran thorough research on all nootropic-based products with their pros, cons, efficacy, customer reviews, pricing, and many other factors and came up with some of the best modafinil alternatives for our users. 

Let’s look at how exactly we manage to do that. 

We began with multiple companies and researched the modafinil products offered by them. With an extensive list of companies, we managed to cross-check and shortlist modafinil products that were completely safe and legitimate to use. 

Next, we headed towards customer reviews for further clarity. We believe that customer reviews are one smart way of knowing the exact picture. 

Since modafinil products are smart drugs and play an important role in cognitive enhancement, the chances are that the reviews will be honest and open. 

Nonetheless, for further confirmation, if necessary, we even personally order some of the best modafinil alternatives and check their usage and efficacy.  

Some of these cognitive enhancers, AKA modafinil alternatives, are enlisted in this article, followed by a brief description and pros/cons.

What Makes a Good Modafinil Alternative?

Modafinil is one of the potent synthetic nootropics widely renowned for its use in brain clarity, cognitive function, and most importantly, functions as a wake-promoting agent. 

Multiple clinical drug investigations reveal several factors responsible for the rising popularity of modafinil as one of the smart drugs for brain health. 

To begin with, research backs up the idea of using modafinil as a supplement for high-pressure jobs and stressful day-to-day scenarios. Thus, you might wonder why that is the case. It’s because modafinil can ameliorate the sleep-wakefulness cycle, keeping a person more vigilant and aware of their surroundings. 

Modafinil is one of the synthetic nootropics that has virtually zero side effects. The drug is completely safe and legit to be used as a stimulant. 

Modafinil, unlike other drugs, has a very reduced potential to cause addiction. It keeps you awake and decreases cognitive impairment without giving you a feeling of euphoria or what is commonly called getting high! 

Modafinil helps you improve focus, reduces fatigue, maintains the sleep-wake cycle, and is also used as a therapeutic agent in narcolepsy. 

Thus, other potential modafinil alternatives need to be able to cause similar benefits as modafinil. Even the best modafinil alternatives cannot meet the diverse range of benefits provided by modafinil itself. 

What Nootropic is better than modafinil?

According to various sources, Mind Lab Pro is a better nootropic than modafinil. Both of these nootropics are powerful stimulants of our nervous system and lead to numerous advantages for our brain. However, certain differences between the two led Mind Lab Pro to a superior position over modafinil. 

Mind Lab Pro can be purchased off the table without any prescriptions because of no reported side effects. Mind Lab Pro includes some of the most natural ingredients, including Bacopa Monnieri providing an additional herbal remedy. Besides that, it also includes lion’s mane mushroom, several amino acids, and vitamins. 

Mind Lab Pro provides neuroprotective properties to CNS, thus protecting against neurodegenerative disorders. With its herbal ingredients, Mind Lab Pro also offers antioxidant properties. 

Best Modafinil Natural Alternative

People are often reluctant to opt for synthetic products. For them, the more natural the product is, the better. Thus, synthetic modafinil might not be the first choice for them. But, in this review, we will cover one of the natural modafinil alternatives as well. 

Ginkgo Biloba has been a part of Chinese tradition for many years. People have used the leaves of this maidenhair tree to treat conditions related to their nervous, respiratory, and circulatory systems. 

The benefits provided by Ginkgo Biloba are because of its antioxidative, anti-inflammatory properties alongside the maintenance of neurotransmitters. It is used to treat Alzheimer’s disease, fatigue, and erectile dysfunction, along with preserving memory. 

However, extensive research is required to know more about how Ginkgo Biloba exerts its effects on our bodies. 

Where to Buy the Best Modafinil Alternative?

If you’re looking for some of the promising vendors for your modafinil alternatives, you’re right. This review will provide a brief yet straightforward answer to all your queries regarding vendors that provide some of the potent modafinil alternatives. Some of these are mentioned below: 

  • Nootropics Depot: This Arizona-based nootropic company provides some legitimate and third-party tested nootropics to their customers. Their products are made with natural ingredients and thus are not prone to any side effects. 
  • Pure Nootropics: Their products are classified under high ratings with great customer services and low yet affordable prices. 
  • Bulk Supplements: This vendor offers some of the best herbal-based nootropic products to their customers. Their FDA-approved facility and third-party testing attract a greater number of audiences.
  • Double Wood Supplements: The brand specializes in products that improve motivation, focus, and concentration. With their third-party testing and GMO-free products, Double Wood Supplements is one of the best vendors to look for. 

To know more about these vendors, click here to read my unbiased opinion on the “Best Nootropic Companies”. 

Where to Buy Modafinil Online?

Several modafinil online vendors supply some of the best modafinil to their customers. Their pricing, shipping, ingredients of the products, customer service, and refund policies led to great customer reviews on their websites. 

Let’s head over to some of the best modafinil vendors out there in the market. 

  • ModafinilXL: This outlet provides the highest quality of products to its customers. Their exciting deals and free sampling policy are ways to figure out why customers are so attracted to the vendor. 
  • It is one of the most popular generic modafinil brands that ships its product from India. Their free sample policy and seven working days have made it more feasible for the customers.
  • The vendor provides high-quality modafinil at low prices formed from Indian Pharmaceuticals such as Sun Pharma and Hab Pharma. 

Is Adrafinil similar to modafinil?

Adrafinil is basically a prodrug of modafinil. This means that the drug is metabolized in vivo to modafinil resulting in similar yet less potent pharmacological benefits than modafinil itself. However, adrafinil is currently unregulated in the United States. 

Can I buy modafinil online?

Modafinil is a legalized smart drug and is available in most stores in the United States. Most of these stores are online vendors who, besides selling modafinil, also provide a range of different nootropics to their customers. 

Can you take modafinil every day?

The recommended intake of modafinil is 200 mg once every day. The drug has decreased potential to result in any addiction and thus is quite well tolerated for a nootropic. 

Does modafinil deplete dopamine? 

Several studies have shown an increased association between modafinil and dopamine. Evidence suggests that modafinil can potentially cause a surge in extracellular dopamine levels. Results further back up the idea by mentioning clinical evidence, such as mice without dopamine receptors showed no effect/response to modafinil injection. 

Does modafinil damage the brain?

To the best of our knowledge, there isn’t much research-based evidence available to back up whether modafinil can damage or cause any harm to the human brain. However, like every other supplement, there’s a safe recommended dosage for modafinil. Going above the advised dose can perhaps result in unpleasant consequences. 

How long does 200mg modafinil last?

On average, with 200 mg modafinil intake, it is expected for a person to be able to experience its effects for about 16-22 hrs at the maximum. 

How long does 400 mg modafinil last?

With 200 mg modafinil lasting for approximately 16-22 hrs, it would make sense that supplementing with 400 mg instead would result in approximately double duration. 

Does modafinil show up in drug tests?

Modafinil/Provigil/modvigil can be detected in urine and blood samples; however, they’re perhaps not commonly included in drug tests/screening methods. 

Does the military test for modafinil?

More confirmation is needed on this matter. However, the US has authorized modafinil on certain air force missions. In 2012, modafinil was the only drug approved for its use in fatigue. 

Kartik Kumar Rathi

Kartik is a Doctor in training currently in his second year of medical school with the ultimate goal of becoming a successful cardiologist, he currently contributes to health blogs, research papers and also founded a social health startup to help educate others.

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