The Morning Dose #42: Best Peptides, TRT and Anxiety, Bone Fractures

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In this week’s edition of The Morning Dose:

πŸ’‰ Your Guide to the Best Peptide Vendors

πŸ’₯ Testosterone Shows Promise Against Anxiety

🦴 Testosterone and Bone Fracture Incidence

πŸ’Š Liver Injuries and Anabolics

Let’s inject this.

β˜•οΈ First time reading? I’m James, and this is The Morning Dose. Every week, our team scours hundreds of sources to bring you need-to-know news and insights you won’t find elsewhere. All in 5 minutes.

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πŸ™‹β€β™‚οΈ Featured Article

πŸ’‰ Your Guide to the Best Peptide Vendors

Are you tired of sifting through endless options to find the best peptide suppliers?

We hear you!

That’s why we’ve done the legwork to bring you the ultimate guide to choosing the right peptide company for your needs.

When it comes to selecting the best peptide companies, we understand that certain criteria are non-negotiable.

Here’s what we looked for in our evaluation process:

Pricing Authenticity: We scrutinized each company’s pricing structure to ensure transparency and fairness. Hidden fees and inflated prices are a 🚩red flag🚩 for us.

Payment Options: Convenience is key, which is why we assessed the variety of payment options offered by each company. From credit cards to cryptocurrency, we looked for flexibility and security.

Independent Safety Verifications: Your safety is our top priority. We prioritized companies that undergo rigorous testing and verification processes to ensure the purity and quality of their products.

Genuine Customer Feedback: Who better to trust than fellow users? We scoured customer reviews and testimonials to gauge overall satisfaction and reliability.

Whether you’re a β€œseasoned researcher” or a β€˜novice enthusiast”, our guide will help you make informed decisions and avoid potential pitfalls.

Remember, safety and authenticity should always come first.

With our guide in hand, you’ll be equipped to choose the best peptide company for your needs, knowing that you’re getting quality products at fair prices.

πŸ’₯ Testosterone Shows Promise Against Anxiety

A recent study led by Prof. Shira Knafo from Ben-Gurion University, sheds light on an intriguing connection between anxiety disorders and testosterone levels.

The study delved into the intricate relationship between anxiety and a β€œbrain receptor” called TACR3.

Male rodents with high anxiety levels exhibited lower levels of TACR3 in their hippocampusβ€”a key brain region involved in learning and memory.

This deficiency in TACR3 was found to impair synaptic plasticity, the brain’s remarkable ability to adapt and learn, potentially exacerbating anxiety symptoms.

However, testosterone administration could hold promise in alleviating symptoms associated with TACR3 deficiency.

Testosterone, known for its pivotal role in muscle development and physical performance, may also wield significant influence over mental well-being.

By bolstering synaptic plasticity and modulating neurotransmitter activity, testosterone could potentially enhance cognitive function and resilience to stress.

This groundbreaking finding not only underscores the intricate interplay between hormones and mental health but also opens up exciting avenues for exploration within the realms of fitness optimization and cognitive enhancement.

🦴 Testosterone and Bone Fracture Incidence

A recent randomized controlled trial, involving over 5,000 male participants with hypogonadism, explored the effects of transdermal testosterone replacement therapy (TRT) on bone fracture incidence.

Here’s a brief overview of the study’s key findings:

Study Focus: The primary aim was to assess the impact of TRT on bone fracture risk in men with hypogonadism, a condition characterized by low testosterone levels.

Participants: The trial included men aged 45–80 with clinical hypogonadism and either preexisting cardiovascular disease or increased risk for cardiovascular events.

Study Design: Participants were randomly assigned to receive either transdermal testosterone gel or a placebo, with bone fracture incidence monitored over a 3-year period.

Results: Surprisingly, the study found that men receiving TRT had a higher incidence of bone fractures compared to those in the placebo group.

Implications: These findings challenge previous notions regarding the potential benefits of TRT on bone health in hypogonadal men. It highlights the need for a nuanced understanding of hormone replacement therapies and their potential risks, especially in populations at risk for bone-related issues.

While this study provides valuable insights, it’s essential to acknowledge its limitations, including low adherence rates and the absence of adjustments for multiple comparisons.

Further research is warranted to comprehensively evaluate the effects of TRT on bone fracture risk.

πŸ’Š Liver Injuries and Anabolics

A retrospective case series conducted across nine Australian tertiary hospitals from 2017 to 2023 examined cases of drug-induced liver injury (DILI) attributed to anabolic-androgenic steroids (AAS), selective androgen receptor modulators (SARMs), and bodybuilding supplements (BBS). Here are the key highlights:

Patient Demographics: The study identified 23 cases of DILI, predominantly in males with a median age of 30 years.

Symptoms and Latency: Most patients presented with symptoms, with a median onset of 58 days from the commencement of drug use.

Hospitalization: The majority of cases required hospitalization for investigation or management of DILI.

Diagnosis: DILI was categorized using the Roussel Uclaf Causality Assessment Method, with most cases classified as possible.

Treatment and Outcomes: While most cases had a good prognosis, one patient required liver transplantation. However, there were no reported deaths.

This study underscores the importance of vigilance in monitoring and managing cases of DILI associated with performance-enhancing supplements.

It also highlights the need for a detailed drug history when investigating liver injury cases, particularly in individuals using AAS, SARMs, or BBS.

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-The Morning Dose

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Disclaimer: This content is NOT medical advice. The information included in these emails is intended for entertainment and informational purposes only.

 

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