Nasal peptide sprays! A remarkable fusion of cutting-edge technology and the intricate complexities of the human body.
In this article, we delve into the world of peptide nasal sprays, exploring their role in overall health and how they have the potential to reshape the future of healthcare.
By offering a less invasive pathway of dosing, these could be the next step in peptide therapy – but are they safe, effective, or even worth it?
- Peptide nasal sprays were specifically developed to be used in such a manner.
- Peptide nasal sprays have several advantages, such as decreasing the risk of injection site infections.
- Peptide nasal sprays do have disadvantages, such as dosing being hard to determine.
What Are Peptide Nasal Sprays?
First, we need to make sure that we all understand what peptides are.
Peptide therapy is a medical approach that involves the targeted use of peptides to modulate physiological processes in the human body.
Peptides are short chains of amino acids, which are the building blocks of proteins.
They play a critical role in numerous biological functions, acting as signaling molecules and regulators of various cellular activities.
Peptides are usually injected into the fat of the human body, sometimes the muscle.
However, due to the risk of infections, companies have developed less invasive methods – such as nasal sprays.
Medical nasal sprays operate through intricate biochemical and physiological mechanisms to provide targeted therapeutic effects within the nasal and respiratory passages.
Nasal sprays are administered intranasally, typically as a fine mist or aerosol through a pressurized container or pump. Thus, less risk of infection!
The nasal mucosa is rich in blood vessels and capillaries, providing a large surface area for absorption.
The active ingredients in the spray are absorbed through the mucosal membrane into the bloodstream.
There are some interesting studies to look at when considering the implications of peptides in this realm .
Various clinics and resellers have begun using nasal peptides as an alternative to injectable versions and the results from people are rather good, people like ‘em.
List of Peptide Nasal Sprays:
|Peptide||Dosage||Cycle Length||Benefits||Side Effects||Stacks|
|AOD 9604||300 mcg/day||20 days||Weight loss, prevents hypercholesterolemia||Headache, indigestion||AOD 9604/Semaglutide|
|BPC 157||Not specified||Up to 14 weeks||Recovery from injury, improved gastric function||Abdominal pain||TB 500 / HGH / IGF-1|
|TB500||7.66 mg/week||14 weeks||Rapid recovery from injuries, muscle growth||Injection site pain, abdominal pain||BPC-157 / TB-500|
|CJC-1295||Not specified||8 to 12 weeks||Skin elasticity, muscle growth, fat loss, recovery||Injection site reactions, water retention||Ipamorelin/GHRP-6/TB-500|
There are only certain peptides that are currently available in nasal form, including:
The AOD9604 peptide, derived from hGH, effectively regulates fat metabolism by targeting areas with excess fat deposition.
It achieves this by enhancing fat breakdown (lipolysis) and suppressing fat synthesis (lipogenesis).
Unlike hGH, AOD9604 doesn’t impact insulin levels, reducing the risk of diabetes.
Additionally, it binds to unique receptors to stimulate fat breakdown and influences the release of fat metabolism-related hormones from the pituitary gland.
BPC-157 exerts its therapeutic effects through various mechanisms.
These include promoting angiogenesis (new blood vessel formation) and blocking inhibitory growth factors.
Furthermore, it also enhances tendon cell receptors for accelerated healing, optimizing fibroblast activity for collagen synthesis, influencing neurotransmitters to reduce symptoms of depression and anxiety, and stimulating nitric oxide production to lower blood pressure and manage conditions like hyperkalemia.
TB500, or Thymosin Beta-4, is a synthetic peptide known for its exceptional healing properties.
It works by promoting cell migration, proliferation, and differentiation, aiding tissue repair.
TB500 has applications in wound healing, muscle repair, cardiovascular regeneration, and managing inflammation and joint injuries.
While its potential in various therapies is promising, ongoing research is needed to confirm its safety and effectiveness in clinical use.
CJC-1295 is a potent growth hormone-releasing hormone analog consisting of 30 amino acids.
It was developed by ConjuChem Technologies, initially as an improved version of Sermorelin Acetate.
It comes in two forms, with or without Drug Affinity Complex (DAC), with the DAC version having better bioavailability and a longer half-life due to its binding to blood proteins.
Delta sleep-inducing peptide, DSIP, is a naturally occurring neuropeptide initially extracted from rabbit brain venous blood during slow-wave sleep in the 1970s-1980s.
It’s synthesized in the rabbit’s hypothalamus and targets various areas in the central nervous system.
DSIP, consisting of 9 amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), concentrates in brain regions like the thalamus, cerebral cortex, and cerebellum.
It effectively crosses the blood-brain barrier to initiate its sleep-inducing mechanism.
Epithalon, also known as Epithalon peptide, is a synthetic tetrapeptide composed of 4 amino acids: Ala-Glu-Asp-Gly, with the molecular formula C14H22N4O9.
It is derived from Epithalamin, a natural polypeptide released from the pineal gland, often referred to as the “third eye.”
Epitalon is a synthetic telomerase activator enzyme that upregulates the synthesis of telomerase enzyme by the pineal gland.
Thus, telomeres at the end of chromosomes are renewed and more telomeres are available at the tips of DNA strands even after a cell divides repeatedly.
GHK-Cu peptide primarily focuses on skin protection and regeneration, with additional benefits in lung injuries and wound healing.
It stimulates collagen and glycosaminoglycan synthesis, essential for connective tissue, and tightening sagging skin.
GHK-Cu also regulates metalloproteinases, preventing the accumulation of damaged proteins that can affect facial skin’s appearance.
GHRP-2, a growth hormone secretagogue (GHS), binds to the GHS-R receptor, prompting increased growth hormone (GH) secretion from the anterior pituitary gland.
It achieves this by suppressing somatostatin (GHIH) release, disrupting the negative feedback system, and elevating GH levels.
GHRP-2 acts as an agonist for ghrelin, boosting appetite and hunger while enhancing GH release.
Additionally, GHRP-2 has a modest impact on raising serum hormone levels like prolactin, ACTH, and cortisol.
Hexarelin’s primary function is to induce growth hormone release from the anterior pituitary gland through various mechanisms.
It mimics ghrelin, a stomach-synthesized hormone, binding to the growth hormone secretagogue receptor (GHS-R1a) in the hippocampus, activating pathways for GH release, cardiomyocyte protection, weight regulation, and musculoskeletal development.
HGH-FRAG is a truncated version of Human Growth Hormone, comprising the final 16 amino acids of the original 191-long sequence, with a chemical formula of C39H60N8O13.
However, it operates differently from HGH. Unlike full-length GH, HGH-FRAG cannot bind to Growth Hormone Receptors (GHR) due to its incomplete amino acid sequence.
Consequently, it cannot trigger IGF-1 formation or perform anabolic functions like GH.
HGH-FRAG 176-191 primarily retains the lipolytic properties of GH, making it a popular choice for lipid metabolism-related functions.
Ghrelin, a naturally produced hormone in the gastrointestinal tract, binds to the growth hormone secretagogue receptor (GHS-R1a).
GHSR1a is highly expressed in the hypothalamus and extrahypothalamic regions, as well as in peripheral tissues like adipocytes, cardiomyocytes, and osteoblasts, impacting various functions including glucose-insulin balance, gastrointestinal motility, cardiovascular health, inflammation, and tissue growth and repair.
Melanotan I, or Afamelanotide, is a 13-amino acid peptide sold as Scenesse.
It mimics the endogenous hormone alpha-melanocyte stimulating hormone (α-MSH), initially developed for tanning but has shown effects in preventing phototoxicity and affecting the central nervous system.
In contrast, Melanotan II is a 7-amino acid synthetic peptide with broad effects, primarily targeting melanocortin receptors.
It promotes skin tanning, increases energy, and enhances sexual performance.
Mots-c is a 16-amino acid peptide derived from the mitochondrial genome.
It has been studied for its therapeutic potential, particularly in regulating metabolic pathways related to energy production, weight management, exercise, longevity, and glucose metabolism.
Thanks to its systemic effects, mots-c holds promise as a therapeutic peptide, including potential applications for recreational purposes.
Are Peptide Nasal Sprays as Effective?
The next logical question you might have is whether or not these sprays are effective or not – well, let’s look at the research:
- A very ‘not-perfect’ study published in 2008 did find that peptide nasal sprays have a ton of benefits over their oral counterparts .
“Absorption of the peptide drug desmopressin from the SSG nasal formulation, from a novel sublingual tablet formulation and from a commercial nasal liquid spray was evaluated in a clinical trial. While no improvement over the liquid spray was seen with the sublingual tablet, plasma concentrations after the nasal powder formulation were three times higher than those after the liquid spray.”
- A study published in 2021 found some interesting results looking at the absorption rates of nasal spray medication in relation to nose structure, mucus, and airflow .
They found a distinct connection between your nose structure and how much of the medication you actually absorb – meaning even though you might buy a good quality peptide, it doesn’t mean you get it all
Overall, these peptides only have one benefit over their counterparts – they don’t need to be injected, meaning there is a far lower risk of infections and other such complications.
Are Peptide Nasal Sprays Safe?
There are no human studies looking at the safety of anti-aging peptides and their nasal application, unfortunately.
However, there are no horror stories online that we know of.
In the realm of peptide therapy, the advent of nasal peptide sprays represents an intriguing fusion of modern technology and human biology.
These sprays offer a less invasive means of administration, potentially reshaping the future of healthcare.
While they bring advantages such as reduced risk of infection, there are questions regarding their effectiveness and safety.
Are Nasal Peptides Effective?
Yes, nasal peptides can be effective for various purposes, including drug delivery and therapeutic applications. The nasal route allows for rapid absorption, making it a convenient option for certain peptide formulations.
What is The Best Nasal Peptide Spray?
Determining the best nasal peptide spray depends on individual needs. Consult with a healthcare professional to find a suitable option tailored to your specific health goals and conditions.
What Peptides Help With Seizures?
Certain peptides, such as neuropeptide Y (NPY), show potential in modulating neuronal activity and may help with seizures. However, it’s crucial to consult a medical professional for personalized advice and treatment.
What is the Best Peptide for Brain Repair?
Peptides like brain-derived neurotrophic factor (BDNF) are known for their neuroprotective and regenerative properties, making them potentially beneficial for brain repair.
- Alabsi W, Eedara BB, Encinas-Basurto D, Polt R, Mansour HM. Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols. Pharmaceutics. 2022 Sep 5;14(9):1870. doi: 10.3390/pharmaceutics14091870. PMID: 36145618; PMCID: PMC9502087.
- Fransén, Nelly (2008). Studies on a Novel Powder Formulation for Nasal Drug Delivery (PhD dissertation). Uppsala University. ISBN 978-91-554-7288-7.
- Shang Y, Inthavong K, Qiu D, Singh N, He F, Tu J. Prediction of nasal spray drug absorption influenced by mucociliary clearance. PLoS One. 2021 Jan 28;16(1):e0246007. doi: 10.1371/journal.pone.0246007. PMID: 33507973; PMCID: PMC7842989.