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Review of Cytolean V2 by Gaspari Nutrition

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First Impressions

There are a total of ten ingredients in Cytolean V2 by Gaspari Nutrition. I am a bit more partial to nutritional products with fewer ingredients because it seems to lend itself less to “pixie dusting”, a practice I described in my previous Muscle and Brawn iForce Maximize review.

That being said, the Cytolean V2 product isn’t a horrible offender. I think that sometimes these products’ ingredients can produce a synergistic effect, too, so it can be a double-edged sword. With “fat burners” or stimulant products in general, there is an amazing array of different feelings they can confer on the user. Pixie dusting is a worse offense when the product in question is a powder-based product. Finally, there is also an ingredient I’ve never seen before: Lactium ®.

Gaspari V2 Ingredients

Pericarpium Citri Reticulatae – This is tangerine peel. Its possible uses, especially from traditional Chinese medicine (its most common application), are incredibly diverse. It is most commonly touted as a digestive aid or tonic.

Paulinia Cupana - This is just Guarana, shame on them. I mean really, was it necessary to hide the fact that your product contains Guarana by deliberately using its botanical name? Guarana is a natural source of caffeine. It’s not the demon ingredient the energy drink decriers make it out to be. At the end of the day, it’s no different chemically than any other source of caffeine.

Lycium Chinense – This is wolfberry/goji berry. It is often lauded for its antioxidant properties and purported anti-aging/longevity effect.

B-Phenylethylamine HCL – You will often see this ingredient abbreviated as PEA or ?-PEA. This is a monoamine (an aromatic group connected to an amino acid by two carbon chains). This one happens to be derived from the aromatic amino acid phenylalanine, as you can probably infer from the name. Phenylethylamines and their substitutions are a very broad class of compounds that include the neurotransmitters epinephrine, norepinephrine, and dopamine; ephedrine; and the (meth)amphetamines and their salts (e.g., Adderall). Please don’t get the wrong idea; I’m not likening ?-PEA to methamphetamines. I’m just pointing out that this is a very interesting compound that is part of a family which contains stimulants and hallucinogens, among other things. It is perfectly safe, however, and most users report increased focus and increased body temperature/feelings of warmth, and even mild euphoric feelings at times. The most commonly reported side effects are mild nausea and mild tightness of the throat, but Cytolean V2 probably does not contain enough ?-PEA to cause these side effects.

Lactium ® – This is a decapeptide (10 amino acids bonded together) that is isolated from casein (milk) protein. It is hydrolyzed (basically, broken down) by the enzyme trypsin, which is secreted by the pancreas into the small intestine.

7b-OH (7b-hydroxy-dehydroepiandrosterone) – This is a downstream metabolite of DHEA and is very similar to 7-keto DHEA. 7b-OH-DHEA has the strongest anti-cortisol/anti-glucocorticoid activity of the supplemental DHEA metabolites, and has shown the greatest propensity to increase resting metabolic rate. This product, Lean Extreme, made the 7b-OH-DHEA ingredient popular in the supplement industry. My personal experience with this ingredient is that it works acutely and rapidly for the first few weeks or so and then tails off in effect, and it specifically targets abdominal fat. Lean Extreme didn’t have any stimulants in it (sigh), but Cytolean V2 has both stimulants and 7b-OH-DHEA (yay!). I do think it is a nice ingredient overall, and worth trying (preferably with stimulants) if you haven’t before.

Huperzine A – This is a plant alkaloid. It has been shown to inhibit the enzyme acetylcholinesterase (AChE). This inhibitory action increases acetylcholine levels in exactly the same way some prescription Alzheimer’s drugs (e.g., Donepezil) do. Without getting too technical, acetylcholine is the primary contractile neurotransmitter of muscle tissue, and in the brain it is involved in plasticity (memory) and excitability (neurotransmitters are chemicals that help your nervous system communicate with other cells). Huperzine A is currently undergoing clinical trials as an Alzheimer’s treatment. This is an interesting ingredient to be in a fat burner as well, and it is also in Gaspari’s other recent product: Mitotropin. It appears that the product formulators at Gaspari Nutrition are fond of this ingredient, and so am I.

Gaspari V2 Effects

The directions are curious with this product; they indicate that you should take all three tablets in the morning. Most products adopt the opposite approach and request that you take some tablets in the morning, and then additional tablets later that day. Anyway, I’ve never been one to back down from a challenge so I threw three pills down the hatch and waited… (While we’re waiting, let me just point out that the pills receive high marks in badassery for having freakin’ daggers on ‘em)

They’ll *ahem* cut you up? (Hopefully) And more gratuitous hand modeling. Calluses are fashionable.

And we’re back. Okay, so they legitimately are not kidding. I was wired, but not in the wild, headachy way that a typical caffeine overdose would yield. I was actually processing everything faster than normal, at least in my own mind.

Final Thoughts

I always tell our customers that fat burners and stimulants are “feel” products. They don’t do much in terms of increasing caloric expenditure directly. Instead, they make you feel certain ways that may be beneficial to your energy or hunger levels, or even your sheer willpower to adhere to the diet. In this way, they increase caloric expenditure indirectly by causing you to eat less and move more. It really is that simple. Furthermore, I am particularly fond of products that impart clarity of focus or improve concentration, and Cytolean V2 did just that.

My criticisms would be the deliberate misdirection with the labeling of the ingredients, and the curious dosing instructions. I do plan to experiment with my own dosing protocol: two tablets in the AM and one capsule mid-afternoon. I am not going to exceed three tablets per day, however, because I would like my bottle to last a whole month.

Cytolean V2 is also designed to neatly stack with Mitotropin, and they are perfect complements to one another because Mitotropin is not “stimulant-y” at all. I am not inherently biased towards Gaspari; they did an excellent job on these products. My recommendation would be to pit this product against any run-of-the-mill hyper-caffeinated fat burner you may be currently taking. The innovation and effect of this product will not disappoint.

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