- Increases Free-Testosterone levels
- Increases Total Testosterone levels
- Inhibits Estrogen
- Influences synergistic thyroid hormone optimization
- Up-regulation of Very Large Fast Twitch (Type II) Muscle Fiber Myosin Heavy Chain Development
- Promotes Conversion of Slow Twitch (Type I) Muscle Fibers To Fast Twitch (Type II) Muscle Fibers
- Enhances the muscle building effects of resistance weight training for greater gains in muscle size and strength
Novatest is a revolutionary scientific breakthrough in testosterone enhancement that incorporates synergistic myosin muscle tissue remodeling effects utilizing a specialized designer Anti-Aromatase Complex and endocrine augmenting co-factors. Novatest is designed to block the action of the aromatase enzyme, which causes a reduction in estrogen levels and a quick and dramatic rise in Free Testosterone levels. In addition to its anti-aromatase action, Novatest activates the precise endocrine pathways required for promoting myosin muscle tissue remodeling to further enhance the muscle building process.
In the development of Novatest, the primary objective of the Xero Limits research team was to identify the most effective way to increase both total and free testosterone levels with the goal of pushing testosterone levels beyond the upper limits of natural production to supra-physiological levels. During this massive research effort, it was first determined that the best way to boost the body’s bioactive testosterone levels was through the utilization of specialized anti-aromatase inhibiting compounds. This approach allows for optimum levels of free testosterone without having the negative feedback inhibition effects and estrogenic elevations caused by other methods.
Pharmakinetic Anti-Aromatase Testosterone Maximizer
Novatest’s anti-aromatase ingredients work synergistically to rapidly inhibit the actions of the endogenous aromatase enzymes of the P450 cytochrome family, thereby blocking the conversion of androstenedione and testosterone into estrogen. Novatest contains a patent pending anti-aromatase complex of androst 1,4,6 triene 3,17 dione and 6 bromo androst 1,4 diene 3, 17 dione (alpha and beta isomers). This complex is bio-engineered to elicit fast-acting aromatase activity and slower acting anti-aromatase moiety for prolonged ultra high Free-Testosterone elevating effects.
The majority of testosterone (approximately 98%) that is transported in the blood is bound to protein carriers, such as sex hormone binding globulin (SHBG) and albumin. Therefore, only a small amount of testosterone (approximately only 2%) is actually free, or bioactive. When testosterone is bound, it cannot exert its anabolic activity at the receptor site. In order for testosterone to be useful, it must be unbound; this is referred to as “Free-Testosterone”. Therefore, the desired goal for optimal muscle building and male performance is to increase Free-Testosterone. Free-Testosterone can also be converted to estrogen via the aromatase enzyme. Therefore, inhibiting the aromatase enzyme’s activity will result in increasing the amount of testosterone, in particular, the free, bioactive testosterone. Novatest’s anti-aromatase activity prevents the aromatization of testosterone, resulting in increased levels of circulating Free-Testosterone and prolonged anabolic action. Independent research also reports that lowering estrogen levels through aromatase inhibition up-regulates testosterone production. Novatest’s pharmacodynamics of increased testosterone production and inhibiting the breakdown of free testosterone through anti-aromatase activities results in cumulative increases in both total testosterone and the free testosterone pool. In fact, the anti-aromatase complex in Novatest is so potent that it has been shown to increase free-testosterone ten fold (10x higher than base line) after only 1 hour of administration. As you can see, the XL research team definitely achieved their objective of increasing natural testosterone production to the upper limits.
Groundbreaking Discovery: Researchers Discover the Synergistic Link between Testosterone and Thyroid Hormone on Myosin Muscle Building Activation
Novatest is the first-ever testosterone formula to incorporate revolutionary myosin activation. Novatest’s dual anabolic action of elevating free testosterone and myosin activation promotes significant increases in muscle fiber size. Novatest has the unique ability to create hormonal conditions favorable for myosin up-regulation and the conversion of small slow twitch muscle fibers to the much larger fast twitch muscle fiber variety. This muscle tissue remodeling, from slow twitch to fast twitch, favorably alters the body’s muscle building potential for much greater gains in size and strength and is required for experiencing maximum increases in strength and muscle size.
During the development of Novatest, the Xero Limits research and development team also analyzed the correlation of thyroid function, thyroid hormone levels and testosterone production. It’s been well established that thyroid hormones, T-3 (Triiodothyronine) and T 4 (Thyroxine) are extremely important in normal development of muscle tissue, in addition to their other functions in the body. Promoting proper thyroid gland function and thyroid hormone levels is required for the development of muscle mass, and also for the differentiation of biochemical and contractile characteristics, such as muscle fiber composition. Low thyroid hormone levels are associated with reduction in muscle mass. Moreover, impaired thyroid function and lower thyroid (T3 and T4) levels have been observed among bodybuilders and power athletes who use synthetic forms of testosterone and anabolic steroids. This endocrine system impairment has led to a common practice among bodybuilders doing their cycles to use synthetic thyroid hormone and offset the down regulation of natural thyroid hormone production caused by anabolic steroids to help with the muscle building and fat burning process.
During their research, Xero Limits scientists uncovered compelling research findings about the correlation and synergistic effects of thyroid function and the testosterone initiated muscle building process. But they also discovered some new groundbreaking research being done at NASA and other top universities on how the up-regulation of thyroid functions poses incredible muscle building effects through the activation of myosin. Myosin is the thick contractile protein that makes up the bulk of muscle fiber. (see illustration).The up-regulation of thyroid activity increases myosin, which in turn allows for the remodeling of slow twitch muscle fibers into fast twitch muscle fibers. It’s the fast twitch muscle fibers which contribute most to muscle size and strength. It was determined that the inclusion of a natural thyroid stimulating hormone activator would be extremely beneficial for not only the optimization of testosterone production, but also to further enhance muscle building through the myosin activation.
Thyroid Hormone Mediated Myosin Muscle Tissue Remodeling
Therefore, the inclusion of an advanced thyrotropic tri-peptide for thyroid hormone up-regulation was added to the Novatest formulation. The inclusion of this thyrotropic tri-peptide has been added to help serve multiple effects; one as a metabolism booster and fat burning catalyst, secondly to maintain testosterone and thyroid hormone homeostasis and thirdly based on the latest research at NASA and top universities, the up-regulation of thyroid activity has been shown to possess incredible muscle building effects through the activation of myosin, which in turn allows for the remodeling of slow twitch muscle fibers in fast twitch.
Myosin is a muscle protein which forms the bulk of skeletal contractile tissue (muscle). One component of myosin is referred to as myosin heavy chain. It is myosin heavy chain that is attributed to playing a central role in muscle cell structure and function. Myosin heavy chain exists in two main isoforms in human muscles, with each isoform being a product of a different gene and stimuli. This gives human muscle tissue the ability to remodel, or change the proportion of myosin heavy chain isoforms. In addition to the training stimulus and high testosterone levels, new research discovered that thyroid hormone is a key regulator of myosin heavy chain production, in particular the larger, fast twitch muscle fiber type myosin heavy chain isoform. Experiments have reported that levels of thyroid hormone in the blood can affect the amount of muscle tissue remodeling. This pioneering research shows thyroid hormone promotes the remodeling of Myosin in the muscle fibers and can regulate the conversion of the smaller slow twitch (type I) muscle fibers into the very large fast twitch (type II) muscle fibers.
This is an enormous bodybuilding breakthrough, as it is the fast twitch muscle fibers that contribute to muscle size and strength. World champion bodybuilders and powerlifters are typically born with more fast twitch muscle fibers. In fact, in the days of Russia’s Iron Curtain, when Olympic competition was viewed as a nation’s physical supremacy, young athletes were tested for their muscle fiber composition and only those with high levels of fast twitch muscle fibers were selected to be trained. Now, Novatest provides a natural way for everyone to nutritionally maximize their fast twitch muscle fiber development in conjunction with resistance training.
Novatest contains a scientifically researched selection of effective ingredients for increaseing total and free-testosterone.
Patent pending Anti-Aromatase Multi-Phase Complex: consists of androst 1,4,6 triene 3,17 dione and 6 bromo androst 1,4 dione 3, 17 dione alpha and beta isomers. Novatest features a maximally effective proprietary aromatase-inhibiting complex bio-engineered to produce a succession of testosterone elevating action via a precise combination of fast acting aromatase-inhibiting ingredients and slower acting anti-aromatase moiety for prolonged ultra-high Free-Testosterone elevating effects.
Thyrotropic Thyroid Hormone Stimulating Compound (Glu-Phe-Pro tri-peptide): Novatest contains a proprietary natural thyroid stimulating tripeptide that stimulates the pituitary gland to release Thyroid Stimulating Hormone (TSH) and activate the production of thyroid hormones (principally T4 also referred to as thyroxin). The Novatest stimulated T4 then travels to the liver where it is converted to the more bioactive T3 (triiodothyronine). In addition to the well-known metabolism boosting effects, T3 also controls myosin heavy chain remodeling in muscle tissue to promote the conversion of smaller slow twitch muscle fibers to the stronger, larger and denser fast twitch muscle fibers that make up the bulk of the huge muscle mass of professional bodybuilders and powerlifters.