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Old 02-11-2012, 12:17 PM   #1
Rich Knapp
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Default Regulation of Organic Metabolism, Growth and Energy Balance

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Regulation of Organic Metabolism, Growth and Energy Balance
- The Human Physiology



Events of Absorptive and Post-absorptive States
Absorptive state is the period during which ingested nutrients enter blood and some of these nutrients supply the energy need of the body while the remainder is stored. Post-absorptive state is the period during which the GI tract is empty of nutrients and body stores must supply required energy.
Absorptive State
Carbohydrates and proteins are absorbed primarily as monosaccharides and amino acids, respectively, into the blood while fat is absorbed as triacylglycerols into the lymph.


Absorbed Carbohydrates
During the absorptive state, glucose is the major energy source and some of it is converted to glycogen and stored in skeletal muscle and liver. In adipose tissue, glucose is transformed and stored as fat.
Absorbed Triacylglycerols
Fatty acids of plasma chylomicrons are released within adipose tissue capillaries and form triacylglycerols.
Absorbed Amino Acids
Most amino acids enter cells and are used to synthesize proteins and any excess amino acids are converted to carbohydrate or fat.
Postabsorptive State
In this state, the net synthesis of glycogen, fat, and protein ceases, and net catabolism of these substances begins. Plasma glucose level is maintained by:
Glycogenolysis, which is the hydrolysis of glycogen stores in liver and skeletal muscles.
Lipolysis, catabolism of triacylglycerols into glycerol and fatty acids in adipose tissues. Any glycerol reaching the liver is converted to glucose.
Protein is catabolized to glucose.
Such new synthesis of glucose is called gluconeogenesis.
Glucose Sparing (Fat Utilization)
Glucose sparing means the reduction of glucose catabolism and increase in fat utilization by most tissues. This spares glucose for the brain and thus protein breakdown is minimized.
Endocrine and Neural Control


Insulin
A peptide hormone secreted by beta (B) cells of islets of Langerhans, in the pancreas. Its secretion is increased during the absorptive state and decreased during the post-absorptive state. Insulin targets are muscular, adipose and liver-tissues. The main roles of insulin are to stimulate the movement of glucose from extracellular fluid into cells by facilitated diffusion, stimulate glycogen synthesis and inhibit glycogen catabolism.
Control of Insulin Secretion
Insulin is controlled by an increase in plasma glucose or amino acid concentration, and the hormone glucose dependent insulinotropic peptide (GIP), which is secreted in the GI tract to stimulate insulin secretion. Parasympathetic fibers stimulate insulin secretion.


Glucagon
Glucagon is a peptide hormone secreted by alpha (A) cells of the pancreas. Its target is the liver tissue and its actions are opposed to that of insulin. Glucagon increases glycogen breakdown and gluconeogenesis to increase the plasma concentration of glucose during the post-absorptive state or when plasma glucose is low (hypoglycemia). Sympathetic nerves stimulate glucagon secretion. On a side note, cortisol and growth hormone also have effects similar to that of glucagon.


Diabetes Mellitus
Diabetes mellitus results from a deficiency of insulin or hyporesponsiveness (slowed response) to insulin.
In insulin dependent diabetes mellitus (IDDM) or type 1 diabetes, insulin is very low or absent as a result of destruction of beta cells. Large amounts of glucose are excreted as the plasma glucose level is very high and the filtered load of glucose exceeds the maximum tubular reabsorptive capacity. Treatment must involve administration of insulin.
In noninsulin-dependent diabetes mellitus (NIDDM) or type 2 diabetes, plasma insulin level is normal but there is target-cell hyporesponsiveness to insulin, termed insulin resistance, which is also related to obesity.


Hypoglycemia
A low plasma glucose level will result from an excess of insulin (beta cells) or deficiency of glucagon (alpha cells).


Regulation of Plasma Cholesterol
The two sources of cholesterol are diet and synthesis by the liver. The liver also excretes cholesterol by adding it to bile. The homeostatic control that keeps the plasma cholesterol constant mainly involves hepatic synthesis.
The ingestion of saturated fatty acids (animal fats) raises plasma cholesterol while unsaturated fatty acids (vegetable fats) lowers it. Low-density lipoproteins (LDL) deliver cholesterol to cells throughout body while high-density lipoproteins (HDL) removes excess cholesterol from blood and tissue and delivers it to the liver for excretion. The ratio of LDL to HDL is important and the lower the ratio, the lower the deposition of extra cholesterol in the blood vessels.
Control of Growth


1. Environmental Factors
Adequacy of nutrient supply is a vital factor in growth.


2. Hormonal Influences


Growth Hormone and Insulin-Like Growth Factors
GH, secreted by anterior pituitary, is the single most important hormone for postnatal growth. An excess of GH produces gigantism, whereas a deficiency produces dwarfism. When excess GH produces bone thickening without lengthening and overgrowth of other organs, it is called acromegaly.
GH exerts its effect on growth by promoting secretion of IGF-I from liver and other tissues. IGF-I promotes cell division, and stimulates protein synthesis by promoting the uptake of amino acids by cells.


Thyroid Hormone
TH is important for controlling metabolism and plays a permissive role in the normal development and maintenance of the nervous system. A decrease in TH during infancy leads to mental retardation, called endemic cretinism.


Insulin
Insulin is an anabolic (building) hormone and inhibits protein degradation. It also promotes cell division and differentiation because it is required for production of IGF-I.


Sex Hormones
Sex hormones stimulate the secretion of GH and IGF-I. Testosterone exerts an anabolic effect by stimulating protein synthesis.


Cortisol
Cortisol exerts antigrowth effects by stimulating protein catabolism (breakdown).


Concepts of Energy Expenditure
The breakdown of organic molecules liberates the energy stored in their bonds. The energy produced is used by cells to perform biological work - muscle contraction (external work) and active transport, molecular synthesis (internal work).
Energy that is liberated (ΔE) during breakdown of an organic molecule can either appear as heat (H) or be used to perform work (W).
ΔE=H+W
Energy for work must first be incorporated into ATP. Heat cannot be converted to work but is used to maintain body temperature and thus homeostasis.
Metabolic Rate
Metabolic rate is the total energy expenditure per unit time. Basal metabolic rate (BMR) is the metabolic rate under certain standardized conditions (subject is at mental and physical rest in a room at a comfortable temperature and has not eaten for 12 hours). Most of the activity contributing to basal metabolic rate is from the activity of the heart, liver, kidney and brain.


Thyroid Hormones
Thyroid hormones are the most important determinant of BMR. They can increase BMR by increasing oxygen consumption and heat-production in most body tissues, which is termed a calorigenic effect, by reducing ATP production.
Epinephrine
Epinephrine increases metabolic rate by calorigenic effect. Epinephrine stimulates the catabolism of glycogen and triacylglycerols.
Food-Induced Thermogenesis
Ingestion of food raises body temperature and protein has the greatest effect in producing temperature changes.


Muscle Activity
Muscle activity increases muscle contraction, e.g., during exercise or shivering, which in turn increases the metabolic rate.


Regulation of Total-Body Energy Stores
Energy stored = Energy from food intake - (Internal heat produced + External work)
The body weight of adults is regulated around a set point by reflexively adjusting caloric intake and/or energy expenditure.


Control of Food Intake
A hormone, leptin, synthesized by adipose tissue, is released in proportion to the amount of fat in adipose tissue. The hormone acts on the hypothalamus to cause a reduction in food intake by inhibiting the release of a neuropeptide that stimulates eating. It also stimulates metabolic rate and therefore controls changes in energy expenditure. Leptin is important in long-term control.
In short-term, various satiety signals such as insulin, body temperature, presence of food in GI tract act on the hypothalamus to regulate the duration and frequency of meals..
Good read, hopes it helps the new people to the sport.
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Old 02-11-2012, 12:20 PM   #2
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Excellent post, Rich

Hope your having a good day.

Best regards,

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