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Old 04-18-2013, 01:57 PM   #1
SecondsOut
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Default Omega-3 might not do s***

More Evidence That Omega-3 Supplements Don't Work - Forbes

Once again researchers have failed to find any clinical benefit for omega-3 supplements. In a new meta-analysis and systematic review published in JAMA, Evangelos Rizos and colleagues analyzed 20 randomized controlled trials including 68,680 patients and found no significant effect on any of the endpoints:

all-cause mortality: relative risk (RR) 0.96, CI 0.91 – 1.02
cardiac death: RR 0.91, CI 0.85 – 0.98 (not significant after correction for multiple comparisons)
sudden death: RR 0.87, CI 0.75 – 1.01
MI: RR 0.89, CI 0.76 – 1.04
stroke: RR 1.05, CI 0.93 – 1.18

The authors reported that they found no evidence supporting a beneficial effect related to either lowering triglycerides or reducing sudden death. Regarding triglycerides, they wrote, “the proposed protective role of omega-3 PUFAs by lowering triglyceride levels is not supported by our study, because our findings do not support an advantage of higher (triglyceride-lowering) doses compared with lower doses of omega-3.” And no benefit was found in preventing sudden death, “thus rejecting a distinct antiarrhythmic mediated omega-3 PUFA effect,” though the authors acknowledged that the evidence was “underpowered to detect a small underlying effect.”

Although early studies suggested a benefit for omega-3 supplements, the accumulation of evidence has resulted in a consistent failure to confirm this benefit, according to the authors. Current evidence, they concluded, does “not justify the use of omega-3 as a structured intervention in everyday clinical practice or guidelines supporting dietary omega-3 PUFAadministration.”
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