The full body 5x5 is a great routine and you'l get used to it quickly. You can start by reducing your weights a little and taking 1-2 weeks to work back up to current levels just to be sure you don't hammer yourself too hard out of the gate.
What is does your current routine look like?
If you are doing a lot of assistance moves/volume now, you might need to reduce some of that if you switch (depending on your work capacity).
Also, is your primary goal pure strength in the SQ, DL, BP, MP or are you less concerned about weights lifted and focused more on pure bodybuilding?